Gene description for BET1L
Gene name Bet1 golgi vesicular membrane trafficking protein-like
Gene symbol BET1L
Other names/aliases BET1L1
GOLIM3
GS15
HSPC197
Species Homo sapiens
 Database cross references - BET1L
ExoCarta ExoCarta_51272
Vesiclepedia VP_51272
Entrez Gene 51272
HGNC 19348
MIM 615417
UniProt Q9NYM9  
 BET1L identified in exosomes derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for BET1L
Molecular Function
    SNAP receptor activity GO:0005484 IBA
    SNAP receptor activity GO:0005484 IDA
    protein binding GO:0005515 IPI
Biological Process
    protein transport GO:0015031 IEA
    retrograde transport, endosome to Golgi GO:0042147 IBA
    retrograde transport, endosome to Golgi GO:0042147 IDA
    membrane fusion GO:0061025 IEA
    regulation of retrograde vesicle-mediated transport, Golgi to ER GO:2000156 IBA
    regulation of retrograde vesicle-mediated transport, Golgi to ER GO:2000156 IMP
Subcellular Localization
    Golgi membrane GO:0000139 TAS
    endosome GO:0005768 IDA
    Golgi apparatus GO:0005794 IDA
    cytosol GO:0005829 IEA
    membrane GO:0016020 HDA
    SNARE complex GO:0031201 IBA
    SNARE complex GO:0031201 TAS
 Experiment description of studies that identified BET1L in exosomes
1
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for BET1L
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SEC22B 9554
Affinity Capture-MS Homo sapiens
2 RAB18 22931
Affinity Capture-MS Homo sapiens
3 HNRNPD 3184
Two-hybrid Homo sapiens
4 VAMP3 9341
Affinity Capture-MS Homo sapiens
5 EBAG9 9166
Proximity Label-MS Homo sapiens
6 NSF 4905
Affinity Capture-MS Homo sapiens
7 METTL7A 25840
Proximity Label-MS Homo sapiens
8 RAB5A 5868
Proximity Label-MS Homo sapiens
9 NRSN1  
Affinity Capture-MS Homo sapiens
10 GOSR1 9527
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
11 LAMP1 3916
Proximity Label-MS Homo sapiens
12 SCFD1 23256
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 HSD3B7 80270
Proximity Label-MS Homo sapiens
14 GJD3  
Proximity Label-MS Homo sapiens
15 UBE3B 89910
Affinity Capture-MS Homo sapiens
16 LAMP2 3920
Proximity Label-MS Homo sapiens
17 GOSR2 9570
Affinity Capture-MS Homo sapiens
18 COPA 1314
Affinity Capture-Western Homo sapiens
19 APP 351
Reconstituted Complex Homo sapiens
20 GORAB 92344
Two-hybrid Homo sapiens
21 ERGIC2 51290
Proximity Label-MS Homo sapiens
22 B3GAT1  
Proximity Label-MS Homo sapiens
23 RAB2A 5862
Proximity Label-MS Homo sapiens
24 VARS 7407
Affinity Capture-MS Homo sapiens
25 RAB7A 7879
Proximity Label-MS Homo sapiens
26 TRAPPC12 51112
Affinity Capture-MS Homo sapiens
27 YKT6 10652
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
28 VAMP5 10791
Affinity Capture-MS Homo sapiens
29 STX5 6811
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
30 STX18 53407
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 CAV1 857
Proximity Label-MS Homo sapiens
32 ELOVL5 60481
Proximity Label-MS Homo sapiens
View the network image/svg+xml



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