Gene description for TERF2IP
Gene name telomeric repeat binding factor 2, interacting protein
Gene symbol TERF2IP
Other names/aliases DRIP5
Species Homo sapiens
 Database cross references - TERF2IP
ExoCarta ExoCarta_54386
Entrez Gene 54386
HGNC 19246
MIM 605061
UniProt Q9NYB0  
 TERF2IP identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for TERF2IP
Molecular Function
    telomeric DNA binding GO:0042162 TAS
    protein binding GO:0005515 IPI
Biological Process
    telomere maintenance via telomere lengthening GO:0010833 ISS
    telomere maintenance via telomerase GO:0007004 TAS
    positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 ISS
    positive regulation of NF-kappaB transcription factor activity GO:0051092 ISS
    negative regulation of telomere maintenance GO:0032205 IMP
    positive regulation of peptidyl-serine phosphorylation GO:0033138 IMP
    protection from non-homologous end joining at telomere GO:0031848 ISS
    protein localization to chromosome, telomeric region GO:0070198 IMP
    regulation of transcription, DNA-templated GO:0006355 ISS
    telomere maintenance GO:0000723 TAS
    positive regulation of protein acetylation GO:1901985 IMP
    negative regulation of DNA recombination at telomere GO:0048239 ISS
    transcription, DNA-templated GO:0006351 IEA
    regulation of double-strand break repair via homologous recombination GO:0010569 ISS
Subcellular Localization
    nucleus GO:0005634 ISS
    nuclear chromosome GO:0000228 TAS
    chromosome, telomeric region GO:0000781 ISS
    nuclear chromosome, telomeric region GO:0000784 IDA
    nucleoplasm GO:0005654 TAS
    nuclear telomere cap complex GO:0000783 IDA
    Mre11 complex GO:0030870 IDA
    nuclear envelope GO:0005635 IEA
    cytoplasm GO:0005737 ISS
 Experiment description of studies that identified TERF2IP in exosomes
Experiment ID 235
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for TERF2IP
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RAD50 10111
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
2 XRCC6 2547
Affinity Capture-MS Homo sapiens
3 AP2B1 163
Two-hybrid Homo sapiens
4 TERF2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
5 TINF2  
Affinity Capture-MS Homo sapiens
6 PARP1 142
Affinity Capture-MS Homo sapiens
7 MRE11A 4361
Affinity Capture-MS Homo sapiens
8 TERF2IP 54386
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
9 XRCC5 7520
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which TERF2IP is involved
DNA Damage/Telomere Stress Induced Senescence TAS Reactome
Meiotic synapsis TAS Reactome
Packaging Of Telomere Ends TAS Reactome

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