Gene description for MAPK8
Gene name	mitogen-activated protein kinase 8
Gene symbol	MAPK8
Other names/aliases	JNK JNK-46 JNK1 JNK1A2 JNK21B1/2 PRKM8 SAPK1 SAPK1c
Species	Homo sapiens
Database cross references - MAPK8
ExoCarta	ExoCarta_5599
Entrez Gene	5599
HGNC	6881
MIM	601158
UniProt	P45983
MAPK8 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells	23333927
Ovarian cancer cells	23333927

Gene ontology annotations for MAPK8

Molecular Function     enzyme binding GO:0019899 IPI     JUN kinase activity GO:0004705 IDA     histone deacetylase regulator activity GO:0035033 IMP     histone deacetylase binding GO:0042826 IPI     ATP binding GO:0005524 IEA     protein serine/threonine kinase activity GO:0004674 IDA     protein binding GO:0005515 IPI Biological Process     stress-activated MAPK cascade GO:0051403 TAS     positive regulation of determination of dorsal identity GO:2000017 IEA     apoptotic process GO:0006915 TAS     MyD88-independent toll-like receptor signaling pathway GO:0002756 TAS     toll-like receptor 2 signaling pathway GO:0034134 TAS     response to stress GO:0006950 TAS     peptidyl-serine phosphorylation GO:0018105 IDA     cellular response to lipopolysaccharide GO:0071222 IDA     positive regulation of deacetylase activity GO:0090045 IMP     toll-like receptor 3 signaling pathway GO:0034138 TAS     JUN phosphorylation GO:0007258 IDA     TRIF-dependent toll-like receptor signaling pathway GO:0035666 TAS     intrinsic apoptotic signaling pathway GO:0097193 TAS     negative regulation of apoptotic process GO:0043066 IDA     innate immune response GO:0045087 TAS     regulation of protein localization GO:0032880 IDA     apoptotic signaling pathway GO:0097190 TAS     response to UV GO:0009411 IDA     MyD88-dependent toll-like receptor signaling pathway GO:0002755 TAS     ossification GO:0001503 IEA     toll-like receptor 10 signaling pathway GO:0034166 TAS     toll-like receptor signaling pathway GO:0002224 TAS     Fc-epsilon receptor signaling pathway GO:0038095 TAS     toll-like receptor 9 signaling pathway GO:0034162 TAS     toll-like receptor TLR6:TLR2 signaling pathway GO:0038124 TAS     toll-like receptor 5 signaling pathway GO:0034146 TAS     cellular response to nitric oxide GO:0071732 IEA     positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:1900740 TAS     programmed necrotic cell death GO:0097300 IEA     regulation of sequence-specific DNA binding transcription factor activity GO:0051090 TAS     cellular response to hydrogen peroxide GO:0070301 IEA     peptidyl-threonine phosphorylation GO:0018107 IMP     response to cadmium ion GO:0046686 IEA     neurotrophin TRK receptor signaling pathway GO:0048011 TAS     positive regulation of protein metabolic process GO:0051247 IMP     positive regulation of gene expression GO:0010628 IMP     toll-like receptor TLR1:TLR2 signaling pathway GO:0038123 TAS     programmed cell death GO:0012501 TAS     cellular response to mechanical stimulus GO:0071260 IEP     negative regulation of protein binding GO:0032091 IDA     regulation of circadian rhythm GO:0042752 ISS     positive regulation of cyclase activity GO:0031281 IMP     rhythmic process GO:0048511 IEA     regulation of histone deacetylation GO:0031063 IMP     positive regulation of apoptotic process GO:0043065 TAS     JNK cascade GO:0007254 TAS     toll-like receptor 4 signaling pathway GO:0034142 TAS     protein phosphorylation GO:0006468 IMP Subcellular Localization     mitochondrion GO:0005739 IEA     nucleoplasm GO:0005654 TAS     cytosol GO:0005829 TAS     nucleus GO:0005634 IDA