Gene description for GSK3A
Gene name glycogen synthase kinase 3 alpha
Gene symbol GSK3A
Other names/aliases -
Species Homo sapiens
 Database cross references - GSK3A
ExoCarta ExoCarta_2931
Entrez Gene 2931
HGNC 4616
MIM 606784
UniProt P49840  
 GSK3A identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for GSK3A
Molecular Function
    protein kinase A catalytic subunit binding GO:0034236 IPI
    ATP binding GO:0005524 IEA
    protein binding GO:0005515 IPI
    tau-protein kinase activity GO:0050321 TAS
    protein serine/threonine kinase activity GO:0004674 IDA
Biological Process
    cellular response to interleukin-3 GO:0036016 ISS
    negative regulation of glycogen (starch) synthase activity GO:2000466 TAS
    cellular protein metabolic process GO:0044267 TAS
    negative regulation of glycogen biosynthetic process GO:0045719 TAS
    positive regulation of adrenergic receptor signaling pathway GO:0071879 ISS
    positive regulation of heart contraction GO:0045823 ISS
    protein phosphorylation GO:0006468 IDA
    negative regulation of insulin receptor signaling pathway GO:0046627 IMP
    negative regulation of UDP-glucose catabolic process GO:0010905 IC
    negative regulation of transferase activity GO:0051348 IMP
    positive regulation of glycogen (starch) synthase activity GO:2000467 ISS
    regulation of mitochondrion degradation GO:1903146 IMP
    endoplasmic reticulum unfolded protein response GO:0030968 TAS
    innate immune response GO:0045087 TAS
    positive regulation of cAMP biosynthetic process GO:0030819 ISS
    nervous system development GO:0007399 IEA
    negative regulation of TOR signaling GO:0032007 ISS
    negative regulation of cell growth involved in cardiac muscle cell development GO:0061052 ISS
    negative regulation of canonical Wnt signaling pathway GO:0090090 TAS
    positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway GO:1901030 ISS
    fibroblast growth factor receptor signaling pathway GO:0008543 TAS
    Wnt signaling pathway GO:0016055 IEA
    positive regulation of protein targeting to mitochondrion GO:1903955 IMP
    IRE1-mediated unfolded protein response GO:0036498 TAS
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 ISS
    extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 ISS
    regulation of systemic arterial blood pressure GO:0003073 ISS
    epidermal growth factor receptor signaling pathway GO:0007173 TAS
    cardiac left ventricle morphogenesis GO:0003214 ISS
    insulin receptor signaling pathway GO:0008286 ISS
    positive regulation of protein catabolic process GO:0045732 NAS
    cellular response to insulin stimulus GO:0032869 IMP
    negative regulation of glucose import GO:0046325 IMP
    phosphatidylinositol-mediated signaling GO:0048015 TAS
    glycogen metabolic process GO:0005977 IEA
    Fc-epsilon receptor signaling pathway GO:0038095 TAS
    neurotrophin TRK receptor signaling pathway GO:0048011 TAS
    negative regulation of type B pancreatic cell development GO:2000077 TAS
Subcellular Localization
    cytosol GO:0005829 TAS
    beta-catenin destruction complex GO:0030877 TAS
 Experiment description of studies that identified GSK3A in exosomes
1
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for GSK3A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 AR 367
Affinity Capture-Western Homo sapiens
View the network image/svg+xml



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