Gene description for GSK3A
Gene name glycogen synthase kinase 3 alpha
Gene symbol GSK3A
Other names/aliases -
Species Homo sapiens
 Database cross references - GSK3A
ExoCarta ExoCarta_2931
Vesiclepedia VP_2931
Entrez Gene 2931
HGNC 4616
MIM 606784
UniProt P49840  
 GSK3A identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Colorectal cancer cells 34887515    
Embryonic kidney cells 36706192    
Embryonic kidney cells 36706192    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Mesenchymal stem cells 36408942    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
Thymus 23844026    
 Gene ontology annotations for GSK3A
Molecular Function
    protein serine/threonine kinase activity GO:0004674 IBA
    protein serine/threonine kinase activity GO:0004674 IDA
    protein serine/threonine kinase activity GO:0004674 NAS
    protein serine/threonine kinase activity GO:0004674 TAS
    3-phosphoinositide-dependent protein kinase activity GO:0004676 IEA
    DNA-dependent protein kinase activity GO:0004677 IEA
    AMP-activated protein kinase activity GO:0004679 IEA
    eukaryotic translation initiation factor 2alpha kinase activity GO:0004694 IEA
    ribosomal protein S6 kinase activity GO:0004711 IEA
    signaling receptor binding GO:0005102 IPI
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    protein kinase A catalytic subunit binding GO:0034236 IPI
    histone H3S10 kinase activity GO:0035175 IEA
    histone H3T11 kinase activity GO:0035402 IEA
    histone H3T6 kinase activity GO:0035403 IEA
    histone H2AXS139 kinase activity GO:0035979 IEA
    histone H3S28 kinase activity GO:0044022 IEA
    histone H4S1 kinase activity GO:0044023 IEA
    histone H2AS1 kinase activity GO:0044024 IEA
    histone H2BS14 kinase activity GO:0044025 IEA
    tau protein binding GO:0048156 NAS
    tau-protein kinase activity GO:0050321 NAS
    tau-protein kinase activity GO:0050321 TAS
    histone H3T3 kinase activity GO:0072354 IEA
    histone H2AS121 kinase activity GO:0072371 IEA
    Rho-dependent protein serine/threonine kinase activity GO:0072518 IEA
    protein serine kinase activity GO:0106310 IEA
    histone H2BS36 kinase activity GO:0140823 IEA
    histone H3S57 kinase activity GO:0140855 IEA
    histone H3T45 kinase activity GO:0140857 IEA
    histone H2AT120 kinase activity GO:1990244 IEA
Biological Process
    regulation of systemic arterial blood pressure GO:0003073 ISS
    cardiac left ventricle morphogenesis GO:0003214 ISS
    glycogen metabolic process GO:0005977 IEA
    protein phosphorylation GO:0006468 IDA
    G protein-coupled dopamine receptor signaling pathway GO:0007212 NAS
    nervous system development GO:0007399 IEA
    insulin receptor signaling pathway GO:0008286 IBA
    insulin receptor signaling pathway GO:0008286 ISS
    positive regulation of autophagy GO:0010508 IBA
    positive regulation of autophagy GO:0010508 ISS
    positive regulation of gene expression GO:0010628 ISS
    negative regulation of UDP-glucose catabolic process GO:0010905 IC
    regulation of neuron projection development GO:0010975 IBA
    Wnt signaling pathway GO:0016055 IEA
    cell migration GO:0016477 IEA
    peptidyl-threonine phosphorylation GO:0018107 IDA
    viral protein processing GO:0019082 TAS
    cell differentiation GO:0030154 IBA
    positive regulation of protein ubiquitination GO:0031398 IMP
    negative regulation of TOR signaling GO:0032007 IBA
    negative regulation of TOR signaling GO:0032007 ISS
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 IBA
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 IMP
    cellular response to insulin stimulus GO:0032869 IMP
    cellular response to interleukin-3 GO:0036016 ISS
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 ISS
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 NAS
    positive regulation of neuron apoptotic process GO:0043525 IBA
    negative regulation of glycogen biosynthetic process GO:0045719 TAS
    positive regulation of protein catabolic process GO:0045732 NAS
    positive regulation of heart contraction GO:0045823 ISS
    positive regulation of transcription by RNA polymerase II GO:0045944 IEA
    negative regulation of D-glucose import GO:0046325 IMP
    negative regulation of insulin receptor signaling pathway GO:0046627 IMP
    excitatory postsynaptic potential GO:0060079 NAS
    negative regulation of cell growth involved in cardiac muscle cell development GO:0061052 ISS
    regulation of microtubule cytoskeleton organization GO:0070507 IBA
    cellular response to lithium ion GO:0071285 IEA
    cellular response to glucocorticoid stimulus GO:0071385 IEA
    positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway GO:0071879 ISS
    negative regulation of canonical Wnt signaling pathway GO:0090090 IBA
    negative regulation of canonical Wnt signaling pathway GO:0090090 TAS
    extrinsic apoptotic signaling pathway GO:0097191 ISS
    extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 ISS
    positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0106071 ISS
    autosome genomic imprinting GO:0141068 IEA
    positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway GO:1901030 ISS
    regulation of mitophagy GO:1901524 IMP
    positive regulation of amyloid-beta formation GO:1902004 IGI
    positive regulation of amyloid-beta formation GO:1902004 IMP
    positive regulation of protein targeting to mitochondrion GO:1903955 IMP
    negative regulation of glycogen synthase activity, transferring glucose-1-phosphate GO:1904227 IMP
    negative regulation of type B pancreatic cell development GO:2000077 TAS
    negative regulation of glycogen (starch) synthase activity GO:2000466 TAS
    positive regulation of glycogen (starch) synthase activity GO:2000467 ISS
Subcellular Localization
    nucleus GO:0005634 IBA
    cytoplasm GO:0005737 IBA
    mitochondrion GO:0005739 IEA
    cytosol GO:0005829 IBA
    cytosol GO:0005829 TAS
    axon GO:0030424 IBA
    beta-catenin destruction complex GO:0030877 NAS
    beta-catenin destruction complex GO:0030877 TAS
    neuronal cell body GO:0043025 NAS
    apical dendrite GO:0097440 NAS
    postsynapse GO:0098794 IEA
    proximal dendrite GO:1990635 NAS
 Experiment description of studies that identified GSK3A in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 1203
MISEV standards
✔
EM
Biophysical techniques
✔
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
6
Experiment ID 1275
MISEV standards
Biophysical techniques
✔
CD9|TSG101|FLOT1|FLOT2|RAB35|RAB5A|GAPDH|TFRC|CD63|Alix
Enriched markers
✔
PCNA|CANX|GAPDH|HSP90AA1|HSP90B1
Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36706192    
Organism Homo sapiens
Experiment description Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles
Authors "Choi S, Yang Z, Wang Q, Qiao Z, Sun M, Wiggins J, Xiang SH, Lu Q."
Journal name Sci Adv
Publication year 2023
Sample Embryonic kidney cells
Sample name HEK293T
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
7
Experiment ID 1280
MISEV standards
Biophysical techniques
✔
TSG101|CD9|FLOT1|FLOT2|RAB35|RAB5A|GAPDH|TFRC|CD63|Alix
Enriched markers
✔
PCNA|CANX|GAPDH|HSP90AA1|HSP90B1
Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36706192    
Organism Homo sapiens
Experiment description Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles
Authors "Choi S, Yang Z, Wang Q, Qiao Z, Sun M, Wiggins J, Xiang SH, Lu Q."
Journal name Sci Adv
Publication year 2023
Sample Embryonic kidney cells
Sample name HEK293T - Fraction 5
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density 1.151 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
8
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
9
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
10
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
11
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
12
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
13
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
14
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for GSK3A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Krba1  
Two-hybrid Mus musculus
2 CRYBG3  
Affinity Capture-MS Homo sapiens
3 PPP3CA 5530
Affinity Capture-MS Homo sapiens
4 GOLGA6C  
Two-hybrid Homo sapiens
5 PPP1CB 5500
Affinity Capture-MS Homo sapiens
6 MTCH1 23787
Two-hybrid Homo sapiens
7 STAT2 6773
Biochemical Activity Homo sapiens
8 EEF1G 1937
Affinity Capture-MS Homo sapiens
9 RPS3A 6189
Affinity Capture-MS Homo sapiens
10 PRKCD 5580
Biochemical Activity Homo sapiens
11 Arhgef11  
Two-hybrid Mus musculus
12 TBC1D4  
Affinity Capture-MS Homo sapiens
13 SRPK2 6733
Affinity Capture-MS Homo sapiens
14 LDHA 3939
Two-hybrid Homo sapiens
15 AURKAIP1  
Two-hybrid Homo sapiens
16 FMR1 2332
Affinity Capture-MS Homo sapiens
17 RPA2 6118
Proximity Label-MS Homo sapiens
18 DHX15 1665
Affinity Capture-MS Homo sapiens
19 ZC3H14  
Affinity Capture-MS Homo sapiens
20 TBL2 26608
Affinity Capture-MS Homo sapiens
21 RPL10 6134
Affinity Capture-MS Homo sapiens
22 RPL15 6138
Two-hybrid Homo sapiens
23 HSP90AB1 3326
Two-hybrid Homo sapiens
24 KPNA2 3838
Affinity Capture-MS Homo sapiens
25 HNRNPR 10236
Affinity Capture-MS Homo sapiens
26 PRPF40A 55660
Affinity Capture-MS Homo sapiens
27 PRKDC 5591
Biochemical Activity Homo sapiens
28 PARP8  
Affinity Capture-MS Homo sapiens
29 H2AFV 94239
Two-hybrid Homo sapiens
30 LRRC37A2  
Two-hybrid Homo sapiens
31 FRAT2  
Affinity Capture-MS Homo sapiens
32 GSK3A 2931
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
33 PPP1CC 5501
Affinity Capture-MS Homo sapiens
34 RPS9 6203
Affinity Capture-MS Homo sapiens
35 Dact1  
Affinity Capture-Western Rattus norvegicus
36 RPL4 6124
Affinity Capture-MS Homo sapiens
37 RPS20 6224
Affinity Capture-MS Homo sapiens
38 MARK2 2011
Affinity Capture-MS Homo sapiens
39 TRIM28 10155
Affinity Capture-MS Homo sapiens
40 CPZ 8532
Affinity Capture-MS Homo sapiens
41 RPL7A 6130
Affinity Capture-MS Homo sapiens
42 C11orf87  
Affinity Capture-MS Homo sapiens
43 LRP6 4040
Two-hybrid Homo sapiens
44 LTF 4057
Affinity Capture-MS Homo sapiens
45 MDN1 23195
Affinity Capture-MS Homo sapiens
46 DEFA5  
Affinity Capture-MS Homo sapiens
47 PPP3CB  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 RPL18 6141
Affinity Capture-MS Homo sapiens
49 SRRM2 23524
Affinity Capture-MS Homo sapiens
50 KHDRBS1 10657
Affinity Capture-MS Homo sapiens
51 YWHAG 7532
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 FAM193B 54540
Two-hybrid Homo sapiens
53 EWSR1 2130
Affinity Capture-MS Homo sapiens
54 THRAP3 9967
Affinity Capture-MS Homo sapiens
55 DNAJB1 3337
Two-hybrid Homo sapiens
56 SRSF3 6428
Affinity Capture-MS Homo sapiens
57 RCAN1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 CCDC174  
Two-hybrid Homo sapiens
59 Nono 53610
Two-hybrid Mus musculus
60 U2AF1 7307
Affinity Capture-MS Homo sapiens
61 SART1 9092
Affinity Capture-MS Homo sapiens
62 SFN 2810
Affinity Capture-MS Homo sapiens
63 CHTOP  
Two-hybrid Homo sapiens
64 RFX7  
Affinity Capture-MS Homo sapiens
65 RPS15 6209
Two-hybrid Homo sapiens
66 Zbed3  
Two-hybrid Mus musculus
67 KIF21A 55605
Affinity Capture-MS Homo sapiens
68 RPL19 6143
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
69 RBM8A 9939
Affinity Capture-MS Homo sapiens
70 ARHGEF11 9826
Affinity Capture-Western Homo sapiens
71 MAP2 4133
Affinity Capture-MS Homo sapiens
72 SAMHD1 25939
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
73 RUNX1  
Two-hybrid Homo sapiens
74 ZDHHC17 23390
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
75 PPP1CA 5499
Affinity Capture-MS Homo sapiens
76 ZC3H6  
Affinity Capture-MS Homo sapiens
77 SPG21 51324
Two-hybrid Homo sapiens
78 RPS19 6223
Two-hybrid Homo sapiens
79 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
80 YWHAB 7529
Affinity Capture-MS Homo sapiens
81 DCP1B  
Two-hybrid Homo sapiens
82 SRRM1 10250
Affinity Capture-MS Homo sapiens
83 PARK2  
Affinity Capture-MS Homo sapiens
84 ACR  
Affinity Capture-MS Homo sapiens
85 SBSN 374897
Affinity Capture-MS Homo sapiens
86 NBR1 4077
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
87 KRBA1  
Affinity Capture-Western Homo sapiens
88 TOPORS  
Affinity Capture-MS Homo sapiens
89 NONO 4841
Affinity Capture-MS Homo sapiens
90 PABPC4 8761
Affinity Capture-MS Homo sapiens
91 CCT5 22948
Affinity Capture-MS Homo sapiens
92 ACIN1 22985
Affinity Capture-MS Homo sapiens
93 TUFM 7284
Affinity Capture-MS Homo sapiens
94 PRKCG 5582
Biochemical Activity Homo sapiens
95 ARG1 383
Affinity Capture-MS Homo sapiens
96 RPL5 6125
Affinity Capture-MS Homo sapiens
97 MAPT  
Biochemical Activity Homo sapiens
98 AIM1 202
Affinity Capture-MS Homo sapiens
99 TNRC18  
Affinity Capture-MS Homo sapiens
100 SRBD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
101 DDX5 1655
Affinity Capture-MS Homo sapiens
102 OGT 8473
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
103 PLRG1 5356
Affinity Capture-MS Homo sapiens
104 GLI3 2737
Biochemical Activity Homo sapiens
105 PABPC1 26986
Affinity Capture-MS Homo sapiens
106 U2AF2 11338
Affinity Capture-MS Homo sapiens
107 PPP2CA 5515
Affinity Capture-MS Homo sapiens
108 SMAD2 4087
Affinity Capture-MS Homo sapiens
109 YWHAQ 10971
Affinity Capture-MS Homo sapiens
110 DDX54 79039
Affinity Capture-MS Homo sapiens
111 UBTF 7343
Two-hybrid Homo sapiens
112 AKAP11 11215
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
113 HMBS 3145
Two-hybrid Homo sapiens
114 HIST1H2BK 85236
Affinity Capture-MS Homo sapiens
115 RRP1B 23076
Affinity Capture-MS Homo sapiens
116 VCPIP1 80124
Two-hybrid Homo sapiens
117 RPS15A 6210
Affinity Capture-MS Homo sapiens
118 PRKAR1A 5573
Affinity Capture-MS Homo sapiens
119 PRKACB 5567
Affinity Capture-MS Homo sapiens
120 SRPK1 6732
Affinity Capture-MS Homo sapiens
121 RPL29 6159
Two-hybrid Homo sapiens
122 RPL11 6135
Affinity Capture-MS Homo sapiens
123 BCLAF1 9774
Affinity Capture-MS Homo sapiens
124 HMGN1  
Two-hybrid Homo sapiens
125 HIST1H2AD 3013
Affinity Capture-MS Homo sapiens
126 HSPA5 3309
Affinity Capture-MS Homo sapiens
127 RPL32 6161
Affinity Capture-MS Homo sapiens
128 SMG7  
Two-hybrid Homo sapiens
129 ZNF664  
Affinity Capture-MS Homo sapiens
130 DDI1  
Two-hybrid Homo sapiens
131 PXN 5829
Affinity Capture-MS Homo sapiens
132 AHDC1  
Affinity Capture-MS Homo sapiens
133 RPL13 6137
Affinity Capture-MS Homo sapiens
134 Axin1  
Two-hybrid Mus musculus
135 SMARCA5 8467
Two-hybrid Homo sapiens
136 FXR1 8087
Affinity Capture-MS Homo sapiens
137 PNN 5411
Affinity Capture-MS Homo sapiens
138 AKAP9 10142
Affinity Capture-MS Homo sapiens
139 CTNNB1 1499
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
140 SRSF1 6426
Affinity Capture-MS Homo sapiens
141 ALKBH3  
Two-hybrid Homo sapiens
142 WDR33 55339
Affinity Capture-MS Homo sapiens
143 RICTOR 253260
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
144 RPL21 6144
Affinity Capture-MS Homo sapiens
145 EBNA1BP2 10969
Biochemical Activity Homo sapiens
146 PPP3R2  
Affinity Capture-MS Homo sapiens
147 GGCT 79017
Affinity Capture-MS Homo sapiens
148 Prune  
Two-hybrid Mus musculus
149 PRUNE 58497
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
150 BCCIP 56647
Two-hybrid Homo sapiens
151 AXIN2 8313
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
152 Map3k11  
Two-hybrid Mus musculus
153 GLUD1 2746
Affinity Capture-MS Homo sapiens
154 SF3A1 10291
Affinity Capture-MS Homo sapiens
155 DCAF8 50717
Two-hybrid Homo sapiens
156 RPS27 6232
Affinity Capture-MS Homo sapiens
157 PRKACA 5566
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
158 PSMD8 5714
Two-hybrid Homo sapiens
159 MAEA 10296
Two-hybrid Homo sapiens
160 Vta1 66201
Two-hybrid Mus musculus
161 PPP3R1 5534
Affinity Capture-MS Homo sapiens
162 STAT1 6772
Affinity Capture-MS Homo sapiens
163 MYC  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
164 RPA3 6119
Proximity Label-MS Homo sapiens
165 NIN 51199
Proximity Label-MS Homo sapiens
166 C11orf98  
Two-hybrid Homo sapiens
167 TTC16  
Two-hybrid Homo sapiens
168 FRAT1 10023
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
169 SBNO1 55206
Two-hybrid Homo sapiens
170 FCGR2B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
171 BICD1 636
Proximity Label-MS Homo sapiens
172 RCAN2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
173 EIF2S2 8894
Affinity Capture-MS Homo sapiens
174 CTNNA1 1495
Affinity Capture-MS Homo sapiens
175 AKT1 207
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
176 TSR1 55720
Affinity Capture-MS Homo sapiens
177 RAE1 8480
Co-fractionation Homo sapiens
178 Prox2  
Two-hybrid Mus musculus
179 U2SURP 23350
Affinity Capture-MS Homo sapiens
180 FBXO42  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
181 MARK3 4140
Affinity Capture-MS Homo sapiens
182 YBX1 4904
Affinity Capture-MS Homo sapiens
183 SPICE1  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
184 TRAK2 66008
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
185 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
186 SLC25A11 8402
Affinity Capture-MS Homo sapiens
187 Gm4779  
Two-hybrid Mus musculus
188 PRKCB 5579
Biochemical Activity Homo sapiens
189 PARP1 142
Affinity Capture-MS Homo sapiens
190 NUP133 55746
Affinity Capture-MS Homo sapiens
191 Spice1  
Two-hybrid Mus musculus
192 RPL6 6128
Affinity Capture-MS Homo sapiens
193 RBM25 58517
Affinity Capture-MS Homo sapiens
194 DEAF1 10522
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
195 TALDO1 6888
Affinity Capture-MS Homo sapiens
196 PIN1 5300
Affinity Capture-Western Homo sapiens
197 HDAC6 10013
Affinity Capture-Western Homo sapiens
198 CHTF18 63922
Affinity Capture-MS Homo sapiens
199 KANK1  
Affinity Capture-MS Homo sapiens
200 PRKAR1B  
Affinity Capture-MS Homo sapiens
201 RPS18 6222
Affinity Capture-MS Homo sapiens
202 HNRNPM 4670
Two-hybrid Homo sapiens
203 PTBP1 5725
Affinity Capture-MS Homo sapiens
204 G3BP1 10146
Affinity Capture-MS Homo sapiens
205 PRKCH 5583
Biochemical Activity Homo sapiens
206 PTMA 5757
Two-hybrid Homo sapiens
207 GSKIP  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
208 HDAC1 3065
Affinity Capture-MS Homo sapiens
209 VTA1 51534
Affinity Capture-Western Homo sapiens
210 HSP90AA1 3320
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
211 PUF60 22827
Affinity Capture-MS Homo sapiens
212 PTBP2  
Co-fractionation Homo sapiens
213 CREB1  
Biochemical Activity Homo sapiens
214 AXIN1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
215 MYL12A 10627
Two-hybrid Homo sapiens
216 HNRNPK 3190
Affinity Capture-MS Homo sapiens
217 SUGP2  
Two-hybrid Homo sapiens
218 RPS26 6231
Affinity Capture-MS Homo sapiens
219 TLR9  
Affinity Capture-MS Homo sapiens
220 KLF5  
Affinity Capture-MS Homo sapiens
221 GSK3B 2932
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
222 DDX3X 1654
Affinity Capture-MS Homo sapiens
223 SF3B3 23450
Affinity Capture-MS Homo sapiens
224 PPP1R2 5504
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
225 ARSG 22901
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
226 PRSS37  
Affinity Capture-MS Homo sapiens
227 PRKCA 5578
Biochemical Activity Homo sapiens
228 MAP3K11 4296
Affinity Capture-Western Homo sapiens
229 RPS8 6202
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
230 Nbr1  
Two-hybrid Mus musculus
231 POLR3B 55703
Affinity Capture-MS Homo sapiens
232 ACACB 32
Affinity Capture-MS Homo sapiens
233 FOXM1  
Affinity Capture-Western Homo sapiens
234 SERBP1 26135
Affinity Capture-MS Homo sapiens
235 SNW1 22938
Affinity Capture-MS Homo sapiens
236 AR 367
Affinity Capture-Western Homo sapiens
237 DRC1  
Two-hybrid Homo sapiens
238 RPL36AL 6166
Affinity Capture-MS Homo sapiens
239 PSMD1 5707
Affinity Capture-MS Homo sapiens
240 AP3D1 8943
Two-hybrid Homo sapiens
241 Lzts2  
Two-hybrid Mus musculus
242 FXR2 9513
Affinity Capture-MS Homo sapiens
243 PPP3CC 5533
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
244 Deaf1  
Two-hybrid Mus musculus
245 CNTROB  
Two-hybrid Homo sapiens
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Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here