Gene description for UMPS
Gene name uridine monophosphate synthetase
Gene symbol UMPS
Other names/aliases OPRT
Species Homo sapiens
 Database cross references - UMPS
ExoCarta ExoCarta_7372
Entrez Gene 7372
HGNC 12563
MIM 613891
UniProt P11172  
 UMPS identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Thymus 23844026    
 Gene ontology annotations for UMPS
Molecular Function
    orotate phosphoribosyltransferase activity GO:0004588 TAS
    orotidine-5'-phosphate decarboxylase activity GO:0004590 TAS
Biological Process
    'de novo' UMP biosynthetic process GO:0044205 IEA
    female pregnancy GO:0007565 IEA
    small molecule metabolic process GO:0044281 TAS
    lactation GO:0007595 IEA
    'de novo' pyrimidine nucleobase biosynthetic process GO:0006207 IEA
    pyrimidine nucleoside biosynthetic process GO:0046134 TAS
    cellular response to drug GO:0035690 IEA
    UMP biosynthetic process GO:0006222 IDA
    pyrimidine nucleobase metabolic process GO:0006206 TAS
    nucleobase-containing small molecule metabolic process GO:0055086 TAS
Subcellular Localization
    cytosol GO:0005829 TAS
    cytoplasm GO:0005737 IDA
    nucleus GO:0005634 IDA
 Experiment description of studies that identified UMPS in exosomes
1
Experiment ID 211
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 217
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101
EV Cytosolic markers
✔
CD81|CD9|CD63
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for UMPS
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CDC42EP3 10602
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which UMPS is involved
PathwayEvidenceSource
Pyrimidine biosynthesis TAS Reactome





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