Gene description for TSC2
Gene name	tuberous sclerosis 2
Gene symbol	TSC2
Other names/aliases	LAM PPP1R160 TSC4
Species	Homo sapiens
Database cross references - TSC2
ExoCarta	ExoCarta_7249
Entrez Gene	7249
HGNC	12363
MIM	191092
UniProt	P49815
TSC2 identified in exosomes derived from the following tissue/cell type
Urine	21595033
Urine	21595033
Urine	21595033

Gene ontology annotations for TSC2

Molecular Function     14-3-3 protein binding GO:0071889 IEA     GTPase activator activity GO:0005096 IDA     protein heterodimerization activity GO:0046982 IEA     protein homodimerization activity GO:0042803 IPI     phosphatase binding GO:0019902 IDA     protein binding GO:0005515 IPI Biological Process     protein localization GO:0008104 ISS     protein transport into plasma membrane raft GO:0044861 IEA     Fc-epsilon receptor signaling pathway GO:0038095 TAS     negative regulation of Wnt signaling pathway GO:0030178 IBA     protein kinase B signaling GO:0043491 ISS     viral process GO:0016032 IEA     neural tube closure GO:0001843 ISS     negative regulation of cell size GO:0045792 IEA     negative regulation of protein kinase activity GO:0006469 ISS     negative regulation of MAP kinase activity GO:0043407 IEA     protein heterooligomerization GO:0051291 IEA     negative regulation of TOR signaling GO:0032007 IBA     heart development GO:0007507 ISS     positive regulation of transcription from RNA polymerase II promoter GO:0045944 IEA     cell cycle arrest GO:0007050 TAS     insulin-like growth factor receptor signaling pathway GO:0048009 ISS     epidermal growth factor receptor signaling pathway GO:0007173 TAS     positive regulation of GTPase activity GO:0043547 IBA     negative regulation of insulin receptor signaling pathway GO:0046627 IBA     gene expression GO:0010467 TAS     endocytosis GO:0006897 TAS     response to hypoxia GO:0001666 IEA     negative regulation of protein kinase B signaling GO:0051898 ISS     protein import into nucleus GO:0006606 ISS     cell projection organization GO:0030030 IEA     neurotrophin TRK receptor signaling pathway GO:0048011 TAS     insulin receptor signaling pathway GO:0008286 TAS     regulation of endocytosis GO:0030100 ISS     negative regulation of phosphatidylinositol 3-kinase signaling GO:0014067 ISS     regulation of insulin receptor signaling pathway GO:0046626 ISS     innate immune response GO:0045087 TAS     positive chemotaxis GO:0050918 ISS     negative regulation of cell proliferation GO:0008285 ISS     phosphatidylinositol 3-kinase signaling GO:0014065 IEA     phosphatidylinositol-mediated signaling GO:0048015 TAS     negative regulation of epithelial cell proliferation GO:0050680 IEA     glucose import GO:0046323 IEA     vesicle-mediated transport GO:0016192 TAS     regulation of cell cycle GO:0051726 IBA     transcription initiation from RNA polymerase II promoter GO:0006367 TAS     acute-phase response GO:0006953 IEA     protein homooligomerization GO:0051260 IEA     fibroblast growth factor receptor signaling pathway GO:0008543 TAS Subcellular Localization     TSC1-TSC2 complex GO:0033596 IDA     cytosol GO:0005829 TAS     nucleus GO:0005634 IDA     cytoskeleton GO:0005856 IEA     neuronal cell body GO:0043025 IEA     growth cone GO:0030426 IEA     caveola GO:0005901 IEA     Golgi apparatus GO:0005794 IDA     membrane GO:0016020 IDA     perinuclear region of cytoplasm GO:0048471 IDA     dendrite GO:0030425 IEA     cytoplasm GO:0005737 IDA