Gene description for PTPN11
Gene name	protein tyrosine phosphatase, non-receptor type 11
Gene symbol	PTPN11
Other names/aliases	BPTP3 CFC NS1 PTP-1D PTP2C SH-PTP2 SH-PTP3 SHP2
Species	Homo sapiens
Database cross references - PTPN11
ExoCarta	ExoCarta_5781
Entrez Gene	5781
HGNC	9644
MIM	176876
UniProt	Q06124
PTPN11 identified in exosomes derived from the following tissue/cell type
Endothelial cells	26027894
Hepatocellular carcinoma cells	26054723
Hepatocellular carcinoma cells	26054723
Ovarian cancer cells	23333927
Ovarian cancer cells	23333927
Platelets	25332113
Platelets	25332113
Platelets	25332113
Prostate cancer cells	25844599

Gene ontology annotations for PTPN11

Molecular Function     protein domain specific binding GO:0019904 IEA     non-membrane spanning protein tyrosine phosphatase activity GO:0004726 TAS     insulin receptor substrate binding GO:0043560 IEA     D1 dopamine receptor binding GO:0031748 IEA     peptide hormone receptor binding GO:0051428 IEA     receptor tyrosine kinase binding GO:0030971 IEA     phospholipase binding GO:0043274 IEA     protein binding GO:0005515 IPI     phosphoprotein phosphatase activity GO:0004721 IDA     protein tyrosine phosphatase activity GO:0004725 TAS     insulin receptor binding GO:0005158 IPI     SH3/SH2 adaptor activity GO:0005070 IDA Biological Process     platelet-derived growth factor receptor signaling pathway GO:0048008 IEA     megakaryocyte development GO:0035855 IEA     ERBB signaling pathway GO:0038127 IDA     fibroblast growth factor receptor signaling pathway GO:0008543 TAS     inner ear development GO:0048839 IMP     glucose homeostasis GO:0042593 IEA     insulin receptor signaling pathway GO:0008286 TAS     regulation of interferon-gamma-mediated signaling pathway GO:0060334 TAS     negative regulation of cell adhesion mediated by integrin GO:0033629 IEA     axon guidance GO:0007411 TAS     negative regulation of cortisol secretion GO:0051463 IEA     Fc-epsilon receptor signaling pathway GO:0038095 TAS     heart development GO:0007507 IMP     multicellular organismal reproductive process GO:0048609 IEA     abortive mitotic cell cycle GO:0033277 IEA     negative regulation of insulin secretion GO:0046676 IEA     genitalia development GO:0048806 IMP     ephrin receptor signaling pathway GO:0048013 IDA     DNA damage checkpoint GO:0000077 IEA     positive regulation of hormone secretion GO:0046887 IEA     regulation of cell adhesion mediated by integrin GO:0033628 IMP     cytokine-mediated signaling pathway GO:0019221 TAS     interferon-gamma-mediated signaling pathway GO:0060333 TAS     hormone metabolic process GO:0042445 IEA     peptidyl-tyrosine dephosphorylation GO:0035335 IMP     atrioventricular canal development GO:0036302 IMP     type I interferon signaling pathway GO:0060337 TAS     epidermal growth factor receptor signaling pathway GO:0007173 TAS     regulation of multicellular organism growth GO:0040014 IEA     T cell costimulation GO:0031295 TAS     blood coagulation GO:0007596 TAS     leukocyte migration GO:0050900 TAS     positive regulation of ERK1 and ERK2 cascade GO:0070374 IEA     negative regulation of growth hormone secretion GO:0060125 IEA     integrin-mediated signaling pathway GO:0007229 IEA     positive regulation of glucose import in response to insulin stimulus GO:2001275 IDA     regulation of type I interferon-mediated signaling pathway GO:0060338 TAS     hormone-mediated signaling pathway GO:0009755 IEA     phosphatidylinositol-mediated signaling GO:0048015 TAS     neurotrophin TRK receptor signaling pathway GO:0048011 TAS     platelet formation GO:0030220 IEA     positive regulation of mitotic cell cycle GO:0045931 IEA     regulation of protein export from nucleus GO:0046825 IEA     innate immune response GO:0045087 TAS     activation of MAPK activity GO:0000187 IEA     organ growth GO:0035265 IEA     face morphogenesis GO:0060325 IMP     brain development GO:0007420 IMP     triglyceride metabolic process GO:0006641 IEA Subcellular Localization     protein complex GO:0043234 IEA     nucleus GO:0005634 IDA     mitochondrion GO:0005739 IEA     cytosol GO:0005829 TAS     cytoplasm GO:0005737 IDA