Gene description for DNMT1
Gene name DNA (cytosine-5-)-methyltransferase 1
Gene symbol DNMT1
Other names/aliases ADCADN
AIM
CXXC9
DNMT
HSN1E
MCMT
Species Homo sapiens
 Database cross references - DNMT1
ExoCarta ExoCarta_1786
Vesiclepedia VP_1786
Entrez Gene 1786
HGNC 2976
MIM 126375
UniProt P26358  
 DNMT1 identified in sEVs derived from the following tissue/cell type
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Chondrocytes 35931686    
Chondrocytes 35931686    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Embryonic kidney cells 36706192    
Embryonic kidney cells 36706192    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
 Gene ontology annotations for DNMT1
Molecular Function
    DNA binding GO:0003677 IBA
    DNA binding GO:0003677 IDA
    DNA (cytosine-5-)-methyltransferase activity GO:0003886 IBA
    DNA (cytosine-5-)-methyltransferase activity GO:0003886 IDA
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 IEA
    methyl-CpG binding GO:0008327 IEA
    DNA-methyltransferase activity GO:0009008 IDA
    DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates GO:0051719 IEA
    DNA (cytosine-5-)-methyltransferase activity, acting on CpNpG substrates GO:0051720 IEA
    lncRNA binding GO:0106222 IEA
    promoter-specific chromatin binding GO:1990841 IDA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IEA
    DNA methylation-dependent constitutive heterochromatin formation GO:0006346 IEA
    DNA-templated transcription GO:0006351 IEA
    positive regulation of gene expression GO:0010628 IMP
    negative regulation of gene expression GO:0010629 IMP
    methylation GO:0032259 IEA
    epigenetic programming of gene expression GO:0043045 IEA
    negative regulation of gene expression via chromosomal CpG island methylation GO:0044027 IBA
    negative regulation of gene expression via chromosomal CpG island methylation GO:0044027 IDA
    negative regulation of gene expression via chromosomal CpG island methylation GO:0044027 IMP
    negative regulation of gene expression via chromosomal CpG island methylation GO:0044027 TAS
    cellular response to amino acid stimulus GO:0071230 IEA
    chromosomal DNA methylation maintenance following DNA replication GO:0141119 TAS
    cellular response to bisphenol A GO:1903926 IEA
    positive regulation of vascular associated smooth muscle cell proliferation GO:1904707 IMP
    negative regulation of vascular associated smooth muscle cell apoptotic process GO:1905460 IMP
    negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching GO:1905931 IMP
Subcellular Localization
    female germ cell nucleus GO:0001674 IEA
    nucleus GO:0005634 HDA
    nucleus GO:0005634 IBA
    nucleoplasm GO:0005654 TAS
    replication fork GO:0005657 IEA
    pericentric heterochromatin GO:0005721 IEA
    mitochondrion GO:0005739 HTP
 Experiment description of studies that identified DNMT1 in sEVs
1
Experiment ID 426
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 427
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 497
MISEV standards
✘ Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 498
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 207
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DKO-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
6
Experiment ID 208
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name Dks-8
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 209
MISEV standards
✘ Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DLD-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
8
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
9
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
10
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
11
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
12
Experiment ID 1275
MISEV standards
Biophysical techniques
✔
CD9|TSG101|FLOT1|FLOT2|RAB35|RAB5A|GAPDH|TFRC|CD63|Alix
Enriched markers
✔
PCNA|CANX|GAPDH|HSP90AA1|HSP90B1
Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36706192    
Organism Homo sapiens
Experiment description Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles
Authors "Choi S, Yang Z, Wang Q, Qiao Z, Sun M, Wiggins J, Xiang SH, Lu Q."
Journal name Sci Adv
Publication year 2023
Sample Embryonic kidney cells
Sample name HEK293T
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
13
Experiment ID 1280
MISEV standards
Biophysical techniques
✔
TSG101|CD9|FLOT1|FLOT2|RAB35|RAB5A|GAPDH|TFRC|CD63|Alix
Enriched markers
✔
PCNA|CANX|GAPDH|HSP90AA1|HSP90B1
Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36706192    
Organism Homo sapiens
Experiment description Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles
Authors "Choi S, Yang Z, Wang Q, Qiao Z, Sun M, Wiggins J, Xiang SH, Lu Q."
Journal name Sci Adv
Publication year 2023
Sample Embryonic kidney cells
Sample name HEK293T - Fraction 5
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density 1.151 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
14
Experiment ID 434
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
15
Experiment ID 435
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for DNMT1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-MS Homo sapiens
2 CDC14B 8555
Proximity Label-MS Homo sapiens
3 RNF180  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
4 RIT1 6016
Negative Genetic Homo sapiens
5 E2F1 1869
Co-fractionation Homo sapiens
6 CBX1 10951
Reconstituted Complex Homo sapiens
7 SNRPG 6637
Affinity Capture-MS Homo sapiens
8 HDAC2 3066
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
9 RNF4 6047
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
10 GADD45A  
Affinity Capture-Western Homo sapiens
11 SP1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
12 HIST1H2BG 8339
Proximity Label-MS Homo sapiens
13 BRCA1 672
Affinity Capture-MS Homo sapiens
14 TRIM27  
Two-hybrid Homo sapiens
15 HIST1H2BB 3018
Reconstituted Complex Homo sapiens
16 ZFR 51663
Co-fractionation Homo sapiens
17 DNAJC25 548645
Affinity Capture-MS Homo sapiens
18 DNAJC15  
Affinity Capture-MS Homo sapiens
19 CENPA  
Proximity Label-MS Homo sapiens
20 DNAJB6 10049
Affinity Capture-MS Homo sapiens
21 APEX1 328
Affinity Capture-RNA Homo sapiens
Proximity Label-MS Homo sapiens
22 CHD4 1108
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
23 HDAC3 8841
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
24 ZBTB33  
Affinity Capture-Western Homo sapiens
25 TRIM28 10155
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
26 SP3  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
27 HSPA5 3309
Affinity Capture-MS Homo sapiens
28 WT1  
Affinity Capture-Western Homo sapiens
29 RGS6 9628
Reconstituted Complex Homo sapiens
30 NR2C2  
Affinity Capture-Western Homo sapiens
31 FBXW7  
Affinity Capture-MS Homo sapiens
32 LASP1 3927
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
33 RELN 5649
Co-localization Homo sapiens
34 SUV39H1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
35 STAT3 6774
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
36 TRO  
Cross-Linking-MS (XL-MS) Homo sapiens
37 NSUN3  
Cross-Linking-MS (XL-MS) Homo sapiens
38 HELLS 3070
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
39 DNAJC16  
Affinity Capture-MS Homo sapiens
40 EED  
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
41 NR2C1  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
42 MECP2 4204
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
43 USP7 7874
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
44 CSNK2B 1460
Two-hybrid Homo sapiens
45 SLU7  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
46 MTA2 9219
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
47 GSK3B 2932
Two-hybrid Homo sapiens
48 RUNX1  
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Two-hybrid Homo sapiens
49 RB1 5925
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
50 MKL1 57591
Affinity Capture-Western Homo sapiens
51 CXXC1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
52 PHF20L1  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
53 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
54 CBX3 11335
Proximity Label-MS Homo sapiens
55 CUL4B 8450
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
56 PARK2  
Affinity Capture-MS Homo sapiens
57 BRD3 8019
Affinity Capture-MS Homo sapiens
58 DNAJC2 27000
Co-fractionation Homo sapiens
59 DNMT3A 1788
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
60 RAD9A  
Affinity Capture-Western Homo sapiens
61 HIST1H3E 8353
Affinity Capture-MS Homo sapiens
62 HSCB 150274
Affinity Capture-MS Homo sapiens
63 CCNB1 891
Affinity Capture-MS Homo sapiens
64 RPA2 6118
Proximity Label-MS Homo sapiens
65 NTRK1 4914
Affinity Capture-MS Homo sapiens
66 CBX5 23468
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
67 IFI16 3428
Affinity Capture-MS Homo sapiens
68 CHEK1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
69 YWHAQ 10971
Reconstituted Complex Homo sapiens
70 MBD2 8932
Affinity Capture-Western Homo sapiens
71 ENO1 2023
Cross-Linking-MS (XL-MS) Homo sapiens
72 Pcna 18538
Affinity Capture-MS Mus musculus
73 HECTD1 25831
Affinity Capture-MS Homo sapiens
74 DMAP1 55929
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
75 BRD4 23476
Affinity Capture-MS Homo sapiens
76 DNAJC30  
Affinity Capture-MS Homo sapiens
77 BRAP  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
78 CEBPA  
Protein-peptide Homo sapiens
79 SETD7 80854
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Co-crystal Structure Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
80 DAXX  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
81 RPS6KA6 27330
Two-hybrid Homo sapiens
82 METAP2 10988
Co-fractionation Homo sapiens
83 ATG16L1 55054
Affinity Capture-MS Homo sapiens
84 DNAJB14  
Affinity Capture-MS Homo sapiens
85 PAX6  
Affinity Capture-Western Homo sapiens
86 COPS2 9318
Affinity Capture-MS Homo sapiens
87 DNAJC27  
Affinity Capture-MS Homo sapiens
88 HIST1H3A 8350
Proximity Label-MS Homo sapiens
Reconstituted Complex Homo sapiens
89 CSGALNACT1 55790
Affinity Capture-MS Homo sapiens
90 SMARCA5 8467
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
91 SIRT7  
Affinity Capture-MS Homo sapiens
92 POLD3  
Affinity Capture-Western Homo sapiens
93 CTNNB1 1499
Affinity Capture-Western Homo sapiens
94 MYH14 79784
Affinity Capture-MS Homo sapiens
95 BRD2  
Affinity Capture-MS Homo sapiens
96 MEX3A  
Affinity Capture-RNA Homo sapiens
97 CD274 29126
Affinity Capture-MS Homo sapiens
98 CUL3 8452
Affinity Capture-MS Homo sapiens
99 YWHAZ 7534
Affinity Capture-MS Homo sapiens
100 UHRF2  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
101 MIR9-3  
Co-localization Homo sapiens
102 SUZ12  
Affinity Capture-Western Homo sapiens
103 CDK2 1017
Affinity Capture-MS Homo sapiens
104 RUNX1T1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Two-hybrid Homo sapiens
105 L3MBTL3  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
106 DNMT3B  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Phenotypic Suppression Homo sapiens
Affinity Capture-MS Homo sapiens
107 RPA3 6119
Proximity Label-MS Homo sapiens
108 UHRF1BP1 54887
Affinity Capture-MS Homo sapiens
109 CDKL4  
Affinity Capture-MS Homo sapiens
110 EHMT2 10919
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
111 KAT5  
Affinity Capture-Western Homo sapiens
112 HSPA4 3308
Affinity Capture-MS Homo sapiens
113 DDB1 1642
Affinity Capture-MS Homo sapiens
114 DDRGK1 65992
Affinity Capture-MS Homo sapiens
115 CLPB 81570
Cross-Linking-MS (XL-MS) Homo sapiens
116 AKT1 207
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
117 SPDYE4  
Affinity Capture-MS Homo sapiens
118 GCN1L1 10985
Co-fractionation Homo sapiens
119 PYHIN1  
Affinity Capture-MS Homo sapiens
120 RBBP4 5928
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
121 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
122 UHRF1BP1L 23074
Affinity Capture-MS Homo sapiens
123 PARP1 142
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
124 SNAI1  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
125 DNAJC19 131118
Affinity Capture-MS Homo sapiens
126 TP53 7157
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
127 MBD3 53615
Affinity Capture-Western Homo sapiens
128 MTA1 9112
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
129 GAD1  
Co-localization Homo sapiens
130 HDAC1 3065
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
131 BAZ2A  
Reconstituted Complex Homo sapiens
132 BDNF 627
Co-localization Homo sapiens
133 SIRT1  
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
134 PCNA 5111
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
135 DDX11 1663
Affinity Capture-RNA Homo sapiens
136 KDM1A 23028
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
137 EZH2  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
138 Dctn3  
Affinity Capture-MS Mus musculus
139 DNAJC18  
Affinity Capture-MS Homo sapiens
140 DUOX2 50506
Co-localization Homo sapiens
141 FBP1 2203
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
142 KRAS 3845
Negative Genetic Homo sapiens
143 UHRF1 29128
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-MS Homo sapiens
144 SH3KBP1 30011
Affinity Capture-MS Homo sapiens
145 DNMT1 1786
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
146 ZFP57  
Affinity Capture-Western Homo sapiens
147 DCAF5  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
148 CUL4A 8451
Affinity Capture-Western Homo sapiens
149 EP300 2033
Affinity Capture-MS Homo sapiens
150 Myl12a  
Affinity Capture-MS Mus musculus
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Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here