Gene description for MAPKAPK2
Gene name	mitogen-activated protein kinase-activated protein kinase 2
Gene symbol	MAPKAPK2
Other names/aliases	MAPKAP-K2 MK-2 MK2
Species	Homo sapiens
Database cross references - MAPKAPK2
ExoCarta	ExoCarta_9261
Entrez Gene	9261
HGNC	6887
MIM	602006
UniProt	P49137
MAPKAPK2 identified in exosomes derived from the following tissue/cell type
Thymus	23844026

Gene ontology annotations for MAPKAPK2

Molecular Function     calmodulin-dependent protein kinase activity GO:0004683 IBA     calmodulin binding GO:0005516 IBA     protein serine/threonine kinase activity GO:0004674 IDA     ATP binding GO:0005524 IEA     mitogen-activated protein kinase binding GO:0051019 IBA     calcium-dependent protein serine/threonine kinase activity GO:0009931 IBA     protein binding GO:0005515 IPI     signal transducer activity GO:0004871 TAS     protein kinase activity GO:0004672 TAS Biological Process     toll-like receptor 9 signaling pathway GO:0034162 TAS     G2 DNA damage checkpoint GO:0031572 IMP     toll-like receptor TLR6:TLR2 signaling pathway GO:0038124 TAS     vascular endothelial growth factor receptor signaling pathway GO:0048010 TAS     TRIF-dependent toll-like receptor signaling pathway GO:0035666 TAS     Ras protein signal transduction GO:0007265 TAS     toll-like receptor signaling pathway GO:0002224 TAS     inflammatory response GO:0006954 ISS     peptidyl-serine phosphorylation GO:0018105 IDA     protein autophosphorylation GO:0046777 IBA     gene expression GO:0010467 TAS     MAPK cascade GO:0000165 TAS     regulation of interleukin-6 production GO:0032675 ISS     neurotrophin TRK receptor signaling pathway GO:0048011 TAS     stress-activated MAPK cascade GO:0051403 TAS     innate immune response GO:0045087 TAS     regulation of tumor necrosis factor production GO:0032680 IDA     MyD88-dependent toll-like receptor signaling pathway GO:0002755 TAS     cellular response to heat GO:0034605 TAS     response to lipopolysaccharide GO:0032496 ISS     toll-like receptor 2 signaling pathway GO:0034134 TAS     toll-like receptor 10 signaling pathway GO:0034166 TAS     3'-UTR-mediated mRNA stabilization GO:0070935 IDA     activation of MAPK activity GO:0000187 TAS     toll-like receptor 5 signaling pathway GO:0034146 TAS     MyD88-independent toll-like receptor signaling pathway GO:0002756 TAS     toll-like receptor TLR1:TLR2 signaling pathway GO:0038123 TAS     toll-like receptor 3 signaling pathway GO:0034138 TAS     inner ear development GO:0048839 IEA     macropinocytosis GO:0044351 ISS     protein phosphorylation GO:0006468 TAS     response to cytokine GO:0034097 IDA     arachidonic acid metabolic process GO:0019369 TAS     leukotriene metabolic process GO:0006691 TAS     small molecule metabolic process GO:0044281 TAS     cellular response to DNA damage stimulus GO:0006974 IMP     cellular response to vascular endothelial growth factor stimulus GO:0035924 IMP     toll-like receptor 4 signaling pathway GO:0034142 TAS     regulation of cellular response to heat GO:1900034 TAS     response to stress GO:0006950 IDA Subcellular Localization     centrosome GO:0005813 IDA     extracellular exosome GO:0070062 IDA     nucleoplasm GO:0005654 TAS     cytosol GO:0005829 TAS     cytoplasm GO:0005737 IDA     nucleus GO:0005634 IDA