Gene description for PIK3CA
Gene name phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
Gene symbol PIK3CA
Other names/aliases CLOVE
CWS5
MCAP
MCM
MCMTC
PI3K
p110-alpha
Species Homo sapiens
 Database cross references - PIK3CA
ExoCarta ExoCarta_5290
Vesiclepedia VP_5290
Entrez Gene 5290
HGNC 8975
MIM 171834
UniProt P42336  
 PIK3CA identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
Nasopharyngeal carcinoma cells 21059916    
 Gene ontology annotations for PIK3CA
Molecular Function
    3-phosphoinositide-dependent protein kinase activity GO:0004676 IEA
    DNA-dependent protein kinase activity GO:0004677 IEA
    AMP-activated protein kinase activity GO:0004679 IEA
    eukaryotic translation initiation factor 2alpha kinase activity GO:0004694 IEA
    ribosomal protein S6 kinase activity GO:0004711 IEA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    1-phosphatidylinositol-3-kinase activity GO:0016303 IBA
    1-phosphatidylinositol-3-kinase activity GO:0016303 IDA
    1-phosphatidylinositol-3-kinase activity GO:0016303 ISS
    1-phosphatidylinositol-3-kinase activity GO:0016303 TAS
    protein kinase activator activity GO:0030295 IEA
    1-phosphatidylinositol-4-phosphate 3-kinase activity GO:0035005 IBA
    histone H3S10 kinase activity GO:0035175 IEA
    histone H3T11 kinase activity GO:0035402 IEA
    histone H3T6 kinase activity GO:0035403 IEA
    histone H2AXS139 kinase activity GO:0035979 IEA
    insulin receptor substrate binding GO:0043560 IEA
    histone H3S28 kinase activity GO:0044022 IEA
    histone H4S1 kinase activity GO:0044023 IEA
    histone H2AS1 kinase activity GO:0044024 IEA
    histone H2BS14 kinase activity GO:0044025 IEA
    1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 IBA
    1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 IDA
    1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 TAS
    histone H3T3 kinase activity GO:0072354 IEA
    histone H2AS121 kinase activity GO:0072371 IEA
    Rho-dependent protein serine/threonine kinase activity GO:0072518 IEA
    protein serine kinase activity GO:0106310 IEA
    histone H2BS36 kinase activity GO:0140823 IEA
    histone H3S57 kinase activity GO:0140855 IEA
    histone H3T45 kinase activity GO:0140857 IEA
    histone H2AT120 kinase activity GO:1990244 IEA
Biological Process
    angiogenesis GO:0001525 IEA
    liver development GO:0001889 IEA
    vasculature development GO:0001944 TAS
    glucose metabolic process GO:0006006 IEA
    phagocytosis GO:0006909 IEA
    epidermal growth factor receptor signaling pathway GO:0007173 TAS
    insulin receptor signaling pathway GO:0008286 TAS
    positive regulation of lamellipodium assembly GO:0010592 ISS
    negative regulation of gene expression GO:0010629 IEA
    response to activity GO:0014823 IEA
    response to muscle inactivity GO:0014870 IEA
    negative regulation of macroautophagy GO:0016242 NAS
    cell migration GO:0016477 IBA
    actin cytoskeleton organization GO:0030036 ISS
    platelet activation GO:0030168 TAS
    negative regulation of actin filament depolymerization GO:0030835 ISS
    T cell costimulation GO:0031295 TAS
    positive regulation of TOR signaling GO:0032008 NAS
    cellular response to insulin stimulus GO:0032869 IDA
    response to muscle stretch GO:0035994 ISS
    phosphatidylinositol-3-phosphate biosynthetic process GO:0036092 IBA
    vascular endothelial growth factor signaling pathway GO:0038084 IGI
    regulation of multicellular organism growth GO:0040014 IEA
    response to L-leucine GO:0043201 IEA
    anoikis GO:0043276 NAS
    regulation of cellular respiration GO:0043457 IEA
    phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0043491 IBA
    phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0043491 IGI
    phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0043491 ISS
    negative regulation of neuron apoptotic process GO:0043524 IEA
    endothelial cell migration GO:0043542 TAS
    phosphatidylinositol phosphate biosynthetic process GO:0046854 ISS
    insulin-like growth factor receptor signaling pathway GO:0048009 IEA
    phosphatidylinositol-mediated signaling GO:0048015 IBA
    positive regulation of smooth muscle cell proliferation GO:0048661 IEA
    T cell receptor signaling pathway GO:0050852 TAS
    positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 IGI
    relaxation of cardiac muscle GO:0055119 ISS
    cardiac muscle contraction GO:0060048 TAS
    adipose tissue development GO:0060612 IEA
    cellular response to glucose stimulus GO:0071333 IEA
    cellular response to hydrostatic pressure GO:0071464 ISS
    response to dexamethasone GO:0071548 IEA
    cardiac muscle cell contraction GO:0086003 ISS
    energy homeostasis GO:0097009 IEA
    regulation of actin filament organization GO:0110053 ISS
    autosome genomic imprinting GO:0141068 IEA
    response to butyrate GO:1903544 IEA
    positive regulation of protein localization to membrane GO:1905477 IDA
    negative regulation of fibroblast apoptotic process GO:2000270 IEA
    negative regulation of anoikis GO:2000811 IMP
    negative regulation of anoikis GO:2000811 NAS
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IBA
    phosphatidylinositol 3-kinase complex GO:0005942 ISS
    phosphatidylinositol 3-kinase complex, class IA GO:0005943 IBA
    phosphatidylinositol 3-kinase complex, class IA GO:0005943 IDA
    phosphatidylinositol 3-kinase complex, class IA GO:0005943 IPI
    phosphatidylinositol 3-kinase complex, class IA GO:0005943 NAS
    phosphatidylinositol 3-kinase complex, class IB GO:0005944 IBA
    intercalated disc GO:0014704 ISS
    lamellipodium GO:0030027 IEA
    perinuclear region of cytoplasm GO:0048471 ISS
 Experiment description of studies that identified PIK3CA in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 125
MISEV standards
✘ Biophysical techniques
✔
HSC70|GAPDH|FLOT2
Enriched markers
✔
HSPA5
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 21059916    
Organism Homo sapiens
Experiment description Human tumor virus utilizes exosomes for intercellular communication.
Authors "Meckes DG Jr, Shair KH, Marquitz AR, Kung CP, Edwards RH, Raab-Traub N."
Journal name PNAS
Publication year 2010
Sample Nasopharyngeal carcinoma cells
Sample name C666
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
 Protein-protein interactions for PIK3CA
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ATR  
Protein-peptide Homo sapiens
2 ATPIF1 93974
Two-hybrid Homo sapiens
3 TSPAN14 81619
Affinity Capture-MS Homo sapiens
4 CRK 1398
Affinity Capture-MS Homo sapiens
5 PTPN11 5781
Affinity Capture-Western Homo sapiens
Far Western Homo sapiens
6 APC  
Negative Genetic Homo sapiens
7 ZDHHC1 29800
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 HRAS 3265
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
9 GNAQ 2776
Affinity Capture-Western Homo sapiens
10 CALM1 801
Affinity Capture-MS Homo sapiens
11 CYTH3 9265
PCA Homo sapiens
12 RPS3 6188
Affinity Capture-MS Homo sapiens
13 DNAJB6 10049
Two-hybrid Homo sapiens
14 BTN3A1 11119
Affinity Capture-MS Homo sapiens
15 RPS20 6224
Two-hybrid Homo sapiens
16 ITIH1 3697
Two-hybrid Homo sapiens
17 CTNNB1 1499
Affinity Capture-MS Homo sapiens
18 IL10RB 3588
Positive Genetic Homo sapiens
19 DEFA5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 CNOT3 4849
Affinity Capture-MS Homo sapiens
21 SLC31A1 1317
Affinity Capture-MS Homo sapiens
22 SUN2 25777
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 YWHAH 7533
Affinity Capture-Western Homo sapiens
24 CLTC 1213
Affinity Capture-MS Homo sapiens
25 CD28  
Affinity Capture-Western Homo sapiens
26 WDR5 11091
Affinity Capture-MS Homo sapiens
27 RASGRP3  
Biochemical Activity Homo sapiens
28 EEF1A1 1915
Affinity Capture-MS Homo sapiens
29 APPL1 26060
Co-localization Homo sapiens
30 E2F4  
Positive Genetic Homo sapiens
31 ADAP1  
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
32 NEDD9 4739
Two-hybrid Homo sapiens
33 IRS4 8471
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 MANSC1 54682
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 KIT 3815
Affinity Capture-Western Homo sapiens
36 FASLG 356
Protein-peptide Homo sapiens
37 ERBB3 2065
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
38 AVPR1B  
Affinity Capture-MS Homo sapiens
39 CBL 867
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
40 ARHGEF1 9138
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
41 DDX5 1655
Two-hybrid Homo sapiens
42 NTRK1 4914
Affinity Capture-MS Homo sapiens
43 CHEK1  
Negative Genetic Homo sapiens
44 IL20RA  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 FLRT1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 UBTF 7343
Affinity Capture-Western Homo sapiens
47 MYH10 4628
Affinity Capture-MS Homo sapiens
48 PIK3R1 5295
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-crystal Structure Homo sapiens
FRET Homo sapiens
49 BRAF  
Negative Genetic Homo sapiens
50 ABCB9  
Affinity Capture-MS Homo sapiens
51 Bub1  
Affinity Capture-MS Mus musculus
52 TMEM52B 120939
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 CD40 958
Affinity Capture-Western Homo sapiens
54 UFD1L 7353
Two-hybrid Homo sapiens
55 TSSC1 7260
Synthetic Lethality Homo sapiens
56 LAMP1 3916
Proximity Label-MS Homo sapiens
57 TNFRSF1A 7132
Affinity Capture-Western Homo sapiens
58 TRAF6 7189
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
59 EGFR 1956
Negative Genetic Homo sapiens
60 VARS2  
Two-hybrid Homo sapiens
61 TMEM74  
Affinity Capture-MS Homo sapiens
62 RPS27 6232
Affinity Capture-MS Homo sapiens
63 RRM2 6241
Negative Genetic Homo sapiens
64 KCNE3  
Affinity Capture-MS Homo sapiens
65 DGKZ  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
66 PCBP1 5093
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 STAT1 6772
Biochemical Activity Homo sapiens
68 RASD2  
Reconstituted Complex Homo sapiens
69 ZDHHC18 84243
Affinity Capture-MS Homo sapiens
70 NFKB1 4790
Positive Genetic Homo sapiens
71 AMBP 259
Two-hybrid Homo sapiens
72 AKT1 207
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
PCA Homo sapiens
Biochemical Activity Homo sapiens
73 EFNB2 1948
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 ILF3 3609
Affinity Capture-MS Homo sapiens
75 GSN 2934
Affinity Capture-Western Homo sapiens
76 FTL 2512
Two-hybrid Homo sapiens
77 FASN 2194
Positive Genetic Homo sapiens
78 SGK1  
Reconstituted Complex Homo sapiens
79 GRB2 2885
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 GPR150  
Affinity Capture-MS Homo sapiens
81 RNF19B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
82 HDAC6 10013
Negative Genetic Homo sapiens
83 NLGN3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
84 MATN2 4147
Affinity Capture-MS Homo sapiens
85 HAVCR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
86 DPY30 84661
Affinity Capture-MS Homo sapiens
87 IRS2 8660
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
88 LCK 3932
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
89 SQSTM1 8878
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
90 CYTH2 9266
PCA Homo sapiens
91 HDAC1 3065
Affinity Capture-MS Homo sapiens
92 ZDHHC23  
Affinity Capture-MS Homo sapiens
93 GNB1 2782
Affinity Capture-Western Homo sapiens
94 ESR1  
Affinity Capture-Western Homo sapiens
95 PDK1 5163
PCA Homo sapiens
96 CDK9 1025
Negative Genetic Homo sapiens
97 EPHA2 1969
Proximity Label-MS Homo sapiens
98 TXNIP 10628
Affinity Capture-MS Homo sapiens
99 PIK3R2 5296
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
100 KRAS 3845
Two-hybrid Homo sapiens
Synthetic Lethality Homo sapiens
Proximity Label-MS Homo sapiens
101 KEAP1 9817
Negative Genetic Homo sapiens
102 IRS1 3667
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
103 CAV1 857
Affinity Capture-MS Homo sapiens
104 Anapc7  
Two-hybrid Mus musculus
105 NOTCH1 4851
Affinity Capture-Western Homo sapiens
106 GNAI3 2773
Affinity Capture-MS Homo sapiens
107 PIK3R3 8503
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which PIK3CA is involved
PathwayEvidenceSource
Activated NTRK2 signals through PI3K IEA Reactome
Activated NTRK3 signals through PI3K IEA Reactome
Adaptive Immune System TAS Reactome
Axon guidance TAS Reactome
CD28 co-stimulation TAS Reactome
CD28 dependent PI3K/Akt signaling TAS Reactome
Cell surface interactions at the vascular wall TAS Reactome
Cell-Cell communication IEA Reactome
Cellular responses to mechanical stimuli IEA Reactome
Cellular responses to stimuli IEA Reactome
Constitutive Signaling by Aberrant PI3K in Cancer TAS Reactome
Constitutive Signaling by EGFRvIII TAS Reactome
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants TAS Reactome
Costimulation by the CD28 family TAS Reactome
Cytokine Signaling in Immune system TAS Reactome
Cytokine Signaling in Immune system IEA Reactome
DAP12 interactions TAS Reactome
DAP12 signaling TAS Reactome
Developmental Biology TAS Reactome
Disease TAS Reactome
Diseases of signal transduction by growth factor receptors and second messengers TAS Reactome
Downstream signal transduction TAS Reactome
Downstream signaling of activated FGFR1 TAS Reactome
Downstream signaling of activated FGFR2 TAS Reactome
Downstream signaling of activated FGFR3 TAS Reactome
Downstream signaling of activated FGFR4 TAS Reactome
Downstream TCR signaling TAS Reactome
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) TAS Reactome
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) IEA Reactome
ESR-mediated signaling TAS Reactome
Extra-nuclear estrogen signaling TAS Reactome
Fc epsilon receptor (FCERI) signaling TAS Reactome
Fcgamma receptor (FCGR) dependent phagocytosis TAS Reactome
FGFR1 mutant receptor activation TAS Reactome
FLT3 Signaling TAS Reactome
FLT3 signaling in disease TAS Reactome
G alpha (q) signalling events TAS Reactome
GAB1 signalosome TAS Reactome
GPCR downstream signalling TAS Reactome
GPVI-mediated activation cascade TAS Reactome
Hemostasis TAS Reactome
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells IEA Reactome
IGF1R signaling cascade TAS Reactome
Immune System TAS Reactome
Immune System IEA Reactome
Innate Immune System TAS Reactome
Insulin receptor signalling cascade TAS Reactome
Interleukin receptor SHC signaling TAS Reactome
Interleukin-2 family signaling TAS Reactome
Interleukin-3, Interleukin-5 and GM-CSF signaling TAS Reactome
Interleukin-3, Interleukin-5 and GM-CSF signaling IEA Reactome
Intracellular signaling by second messengers TAS Reactome
IRS-mediated signalling TAS Reactome
IRS-related events triggered by IGF1R TAS Reactome
MAPK family signaling cascades TAS Reactome
MAPK1/MAPK3 signaling TAS Reactome
MET activates PI3K/AKT signaling TAS Reactome
Metabolism TAS Reactome
Metabolism of lipids TAS Reactome
Negative regulation of the PI3K/AKT network TAS Reactome
Nephrin family interactions IEA Reactome
Nervous system development TAS Reactome
Phospholipid metabolism TAS Reactome
PI Metabolism TAS Reactome
PI-3K cascade:FGFR1 TAS Reactome
PI-3K cascade:FGFR2 TAS Reactome
PI-3K cascade:FGFR3 TAS Reactome
PI-3K cascade:FGFR4 TAS Reactome
PI3K Cascade TAS Reactome
PI3K events in ERBB2 signaling TAS Reactome
PI3K events in ERBB4 signaling TAS Reactome
PI3K/AKT activation TAS Reactome
PI3K/AKT Signaling in Cancer TAS Reactome
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling TAS Reactome
PIP3 activates AKT signaling TAS Reactome
Platelet activation, signaling and aggregation TAS Reactome
RAC1 GTPase cycle TAS Reactome
RAC2 GTPase cycle TAS Reactome
RAF/MAP kinase cascade TAS Reactome
Regulation of signaling by CBL IEA Reactome
Regulation of signaling by CBL TAS Reactome
Response of endothelial cells to shear stress IEA Reactome
RET signaling TAS Reactome
RHO GTPase cycle TAS Reactome
Role of LAT2/NTAL/LAB on calcium mobilization TAS Reactome
Role of phospholipids in phagocytosis TAS Reactome
Signal Transduction TAS Reactome
Signal Transduction IEA Reactome
Signaling by ALK TAS Reactome
Signaling by ALK fusions and activated point mutants TAS Reactome
Signaling by ALK in cancer TAS Reactome
Signaling by CSF1 (M-CSF) in myeloid cells IEA Reactome
Signaling by cytosolic FGFR1 fusion mutants TAS Reactome
Signaling by EGFR TAS Reactome
Signaling by EGFR in Cancer TAS Reactome
Signaling by EGFRvIII in Cancer TAS Reactome
Signaling by ERBB2 TAS Reactome
Signaling by ERBB2 ECD mutants TAS Reactome
Signaling by ERBB2 in Cancer TAS Reactome
Signaling by ERBB2 KD Mutants TAS Reactome
Signaling by ERBB4 TAS Reactome
Signaling by Erythropoietin TAS Reactome
Signaling by Erythropoietin IEA Reactome
Signaling by FGFR TAS Reactome
Signaling by FGFR in disease TAS Reactome
Signaling by FGFR1 TAS Reactome
Signaling by FGFR1 in disease TAS Reactome
Signaling by FGFR2 TAS Reactome
Signaling by FGFR2 in disease TAS Reactome
Signaling by FGFR3 TAS Reactome
Signaling by FGFR3 in disease TAS Reactome
Signaling by FGFR4 TAS Reactome
Signaling by FGFR4 in disease TAS Reactome
Signaling by FLT3 fusion proteins TAS Reactome
Signaling by FLT3 ITD and TKD mutants TAS Reactome
Signaling by GPCR TAS Reactome
Signaling by Insulin receptor TAS Reactome
Signaling by Interleukins TAS Reactome
Signaling by Interleukins IEA Reactome
Signaling by KIT in disease TAS Reactome
Signaling by Ligand-Responsive EGFR Variants in Cancer TAS Reactome
Signaling by LTK TAS Reactome
Signaling by LTK in cancer TAS Reactome
Signaling by MET TAS Reactome
Signaling by NTRK1 (TRKA) TAS Reactome
Signaling by NTRK2 (TRKB) IEA Reactome
Signaling by NTRK3 (TRKC) IEA Reactome
Signaling by NTRKs TAS Reactome
Signaling by NTRKs IEA Reactome
Signaling by Nuclear Receptors TAS Reactome
Signaling by PDGF TAS Reactome
Signaling by PDGFR in disease TAS Reactome
Signaling by PDGFRA extracellular domain mutants TAS Reactome
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants TAS Reactome
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants TAS Reactome
Signaling by Receptor Tyrosine Kinases TAS Reactome
Signaling by Receptor Tyrosine Kinases IEA Reactome
Signaling by Rho GTPases TAS Reactome
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 TAS Reactome
Signaling by SCF-KIT TAS Reactome
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) TAS Reactome
Signaling by VEGF IEA Reactome
Signaling by VEGF TAS Reactome
Synthesis of PIPs at the plasma membrane TAS Reactome
TCR signaling TAS Reactome
Tie2 Signaling TAS Reactome
VEGFA-VEGFR2 Pathway IEA Reactome
VEGFA-VEGFR2 Pathway TAS Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here