Gene description for BAP1
Gene name BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
Gene symbol BAP1
Other names/aliases HUCEP-13
UCHL2
hucep-6
Species Homo sapiens
 Database cross references - BAP1
ExoCarta ExoCarta_8314
Vesiclepedia VP_8314
Entrez Gene 8314
HGNC 950
MIM 603089
UniProt Q92560  
 BAP1 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for BAP1
Molecular Function
    chromatin binding GO:0003682 IDA
    cysteine-type deubiquitinase activity GO:0004843 IBA
    cysteine-type deubiquitinase activity GO:0004843 IDA
    cysteine-type deubiquitinase activity GO:0004843 TAS
    protein binding GO:0005515 IPI
    peptidase activity GO:0008233 NAS
    chromatin DNA binding GO:0031490 IEA
    histone H2A deubiquitinase activity GO:0140950 IMP
Biological Process
    mitotic cell cycle GO:0000278 IEA
    regulation of cell growth GO:0001558 IMP
    in utero embryonic development GO:0001701 IEA
    tissue homeostasis GO:0001894 IEA
    thrombocyte differentiation GO:0002574 IEA
    chromatin remodeling GO:0006338 IEA
    ubiquitin-dependent protein catabolic process GO:0006511 IEA
    negative regulation of cell population proliferation GO:0008285 TAS
    gene expression GO:0010467 IEA
    protein deubiquitination GO:0016579 IDA
    protein deubiquitination GO:0016579 TAS
    neutrophil differentiation GO:0030223 IEA
    heterochromatin formation GO:0031507 IBA
    myeloid cell apoptotic process GO:0033028 IEA
    monoubiquitinated protein deubiquitination GO:0035520 IDA
    common myeloid progenitor cell proliferation GO:0035726 IEA
    protein modification process GO:0036211 NAS
    platelet morphogenesis GO:0036344 IEA
    erythrocyte maturation GO:0043249 IEA
    nucleate erythrocyte differentiation GO:0043363 IEA
    negative regulation of DNA-templated transcription GO:0045892 IDA
    regulation of inflammatory response GO:0050727 IEA
    regulation of cell cycle GO:0051726 IMP
    hematopoietic stem cell homeostasis GO:0061484 IEA
    macrophage homeostasis GO:0061519 IEA
    neuron cellular homeostasis GO:0070050 IEA
    leukocyte proliferation GO:0070661 IEA
    protein K48-linked deubiquitination GO:0071108 IMP
    regulation of cytokine production involved in inflammatory response GO:1900015 IEA
    positive regulation of protein targeting to mitochondrion GO:1903955 HMP
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    chromosome GO:0005694 IEA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 IDA
    PR-DUB complex GO:0035517 IDA
    PR-DUB complex GO:0035517 IPI
 Experiment description of studies that identified BAP1 in exosomes
1
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for BAP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MCRS1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
2 SUCO  
Negative Genetic Homo sapiens
3 EIF4EBP3  
Affinity Capture-MS Homo sapiens
4 CBX1 10951
Affinity Capture-MS Homo sapiens
5 ELF1 1997
Proximity Label-MS Homo sapiens
6 FEV  
Proximity Label-MS Homo sapiens
7 KIAA1107  
Affinity Capture-MS Homo sapiens
8 KPNA1 3836
Protein-peptide Homo sapiens
9 USPL1  
Negative Genetic Homo sapiens
10 TNPO1 3842
Co-crystal Structure Homo sapiens
Protein-peptide Homo sapiens
Reconstituted Complex Homo sapiens
11 EXO1  
Affinity Capture-MS Homo sapiens
12 SP1  
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
13 E2F1 1869
Proximity Label-MS Homo sapiens
Affinity Capture-Western Homo sapiens
14 GATA2  
Proximity Label-MS Homo sapiens
15 EN1  
Proximity Label-MS Homo sapiens
16 BRCA1 672
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
17 MAP4 4134
Affinity Capture-MS Homo sapiens
18 KDM5C  
Negative Genetic Homo sapiens
19 UBC 7316
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
20 KPNA2 3838
Protein-peptide Homo sapiens
21 HSPA1A 3303
Co-purification Homo sapiens
22 ASXL1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
23 ELF4 2000
Proximity Label-MS Homo sapiens
24 MYOD1  
Proximity Label-MS Homo sapiens
25 CREBBP  
Negative Genetic Homo sapiens
26 HIST2H2AA3 8337
Biochemical Activity Homo sapiens
27 HSPA2 3306
Affinity Capture-MS Homo sapiens
28 KLF8  
Proximity Label-MS Homo sapiens
29 UBE2O 63893
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 SDHB 6390
Negative Genetic Homo sapiens
31 TSNAX 7257
Affinity Capture-MS Homo sapiens
32 HCFC2  
Affinity Capture-MS Homo sapiens
33 HIST2H2AC 8338
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
34 BCOR  
Negative Genetic Homo sapiens
35 ANAPC7 51434
Affinity Capture-MS Homo sapiens
36 DHODH 1723
Negative Genetic Homo sapiens
37 USP2  
Biochemical Activity Homo sapiens
38 NPHP3 27031
Affinity Capture-MS Homo sapiens
39 PRPS2 5634
Affinity Capture-MS Homo sapiens
40 AKT1 207
Affinity Capture-Western Homo sapiens
41 PSME3 10197
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 KLF16  
Proximity Label-MS Homo sapiens
43 EFNA2  
Co-purification Homo sapiens
44 CAMK2A 815
Affinity Capture-MS Homo sapiens
45 RBBP7 5931
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
47 IKBIP 121457
Affinity Capture-MS Homo sapiens
48 RRAS2 22800
Negative Genetic Homo sapiens
49 TP53 7157
Affinity Capture-Western Homo sapiens
50 USP21  
Biochemical Activity Homo sapiens
51 ANKRD17 26057
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 LIPT1  
Negative Genetic Homo sapiens
53 COPE 11316
Affinity Capture-MS Homo sapiens
54 TBR1  
Proximity Label-MS Homo sapiens
55 NFIX 4784
Proximity Label-MS Homo sapiens
56 CBX3 11335
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 ANKHD1 54882
Affinity Capture-MS Homo sapiens
58 PIGM  
Negative Genetic Homo sapiens
59 OGT 8473
Affinity Capture-MS Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 FOXK2  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
61 GYS1 2997
Negative Genetic Homo sapiens
62 ZNF131  
Co-purification Homo sapiens
63 GOPC 57120
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 FH 2271
Negative Genetic Homo sapiens
65 NFYC 4802
Proximity Label-MS Homo sapiens
66 SMS 6611
Affinity Capture-MS Homo sapiens
67 MARCH2  
Negative Genetic Homo sapiens
68 VPS25 84313
Affinity Capture-MS Homo sapiens
69 TMEM261  
Negative Genetic Homo sapiens
70 PPM1G 5496
Affinity Capture-MS Homo sapiens
71 USP28 57646
Biochemical Activity Homo sapiens
72 TRIM63  
Biochemical Activity Homo sapiens
73 BZW1 9689
Negative Genetic Homo sapiens
74 CD3EAP  
Proximity Label-MS Homo sapiens
75 SDHD  
Negative Genetic Homo sapiens
76 C16orf72 29035
Negative Genetic Homo sapiens
77 PAX6  
Proximity Label-MS Homo sapiens
78 ASXL2  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-purification Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
79 IPO5 3843
Affinity Capture-MS Homo sapiens
80 ASXL3  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
81 YWHAZ 7534
Affinity Capture-MS Homo sapiens
82 USP15 9958
Biochemical Activity Homo sapiens
83 ELK3  
Proximity Label-MS Homo sapiens
84 TMEM209 84928
Negative Genetic Homo sapiens
85 HCFC1 3054
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Co-purification Homo sapiens
Co-fractionation Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
86 KPNB1 3837
Affinity Capture-MS Homo sapiens
87 TFAP4 7023
Negative Genetic Homo sapiens
88 PTEN 5728
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
89 EGFR 1956
Negative Genetic Homo sapiens
90 MAP3K1 4214
Biochemical Activity Homo sapiens
91 BAP1 8314
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
92 PAPOLA 10914
Negative Genetic Homo sapiens
93 YY1 7528
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Proximity Label-MS Homo sapiens
Co-purification Homo sapiens
Co-fractionation Homo sapiens
Reconstituted Complex Homo sapiens
94 SLC35B2 347734
Negative Genetic Homo sapiens
95 HNF4A  
Proximity Label-MS Homo sapiens
96 PRDM10  
Co-purification Homo sapiens
97 EXT1 2131
Negative Genetic Homo sapiens
98 MYC  
Proximity Label-MS Homo sapiens
99 Sept6  
Affinity Capture-MS Mus musculus
100 INO80  
Affinity Capture-Western Homo sapiens
101 ETS1  
Proximity Label-MS Homo sapiens
102 NDUFAF4 29078
Negative Genetic Homo sapiens
103 DIDO1  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
104 KRAS 3845
Negative Genetic Homo sapiens
105 HAT1 8520
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
106 HSPA9 3313
Co-purification Homo sapiens
107 MYB  
Proximity Label-MS Homo sapiens
108 ENTHD2  
Affinity Capture-MS Homo sapiens
109 FOXK1 221937
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
110 FHL2 2274
Affinity Capture-MS Homo sapiens
111 MBD5 55777
Affinity Capture-MS Homo sapiens
112 ATIC 471
Negative Genetic Homo sapiens
113 AR 367
Proximity Label-MS Homo sapiens
114 STUB1 10273
Negative Genetic Homo sapiens
115 GATAD2A 54815
Negative Genetic Homo sapiens
116 PRKD2 25865
Affinity Capture-MS Homo sapiens
117 TLX1  
Proximity Label-MS Homo sapiens
118 UGP2 7360
Negative Genetic Homo sapiens
119 FASN 2194
Negative Genetic Homo sapiens
120 FDX1 2230
Negative Genetic Homo sapiens
121 Bap1  
Affinity Capture-MS Mus musculus
122 LIPT2  
Negative Genetic Homo sapiens
123 HMGB1 3146
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
124 KDM1B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-purification Homo sapiens
Affinity Capture-MS Homo sapiens
125 KEAP1 9817
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
126 Ogt  
Biochemical Activity Mus musculus
127 HDAC1 3065
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
128 TRA2B 6434
Affinity Capture-MS Homo sapiens
129 KLF5  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
130 AHCYL2 23382
Affinity Capture-MS Homo sapiens
131 COQ2  
Negative Genetic Homo sapiens
132 ALYREF 10189
Affinity Capture-MS Homo sapiens
133 DMPK  
Negative Genetic Homo sapiens
134 PMVK 10654
Negative Genetic Homo sapiens
135 IPO4 79711
Affinity Capture-MS Homo sapiens
136 HIST1H2AB 8335
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
137 STK11 6794
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
138 ZFP36L1  
Affinity Capture-MS Homo sapiens
139 ELF2  
Proximity Label-MS Homo sapiens
Co-purification Homo sapiens
140 HNF1B  
Proximity Label-MS Homo sapiens
141 CAMK2D 817
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
142 ZC3H13 23091
Co-purification Homo sapiens
143 MEIOB  
Negative Genetic Homo sapiens
144 NSUN5  
Affinity Capture-MS Homo sapiens
145 Vbp1  
Affinity Capture-MS Mus musculus
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here