Gene description for LRRK2
Gene name	leucine-rich repeat kinase 2
Gene symbol	LRRK2
Other names/aliases	AURA17 DARDARIN PARK8 RIPK7 ROCO2
Species	Homo sapiens
Database cross references - LRRK2
ExoCarta	ExoCarta_120892
Vesiclepedia	VP_120892
Entrez Gene	120892
HGNC	18618
MIM	609007
UniProt	Q5S007
LRRK2 identified in sEVs derived from the following tissue/cell type
Neuroblastoma cells	25944692
Urine	19056867

Gene ontology annotations for LRRK2

Molecular Function     SNARE binding GO:0000149 IPI     magnesium ion binding GO:0000287 IMP     actin binding GO:0003779 IPI     GTPase activity GO:0003924 IDA     protein kinase activity GO:0004672 IDA     protein serine/threonine kinase activity GO:0004674 EXP     protein serine/threonine kinase activity GO:0004674 IDA     protein serine/threonine kinase activity GO:0004674 IMP     protein serine/threonine kinase activity GO:0004674 TAS     3-phosphoinositide-dependent protein kinase activity GO:0004676 IEA     DNA-dependent protein kinase activity GO:0004677 IEA     AMP-activated protein kinase activity GO:0004679 IEA     eukaryotic translation initiation factor 2alpha kinase activity GO:0004694 IEA     JUN kinase kinase kinase activity GO:0004706 IBA     JUN kinase kinase kinase activity GO:0004706 IDA     MAP kinase kinase kinase activity GO:0004709 IDA     ribosomal protein S6 kinase activity GO:0004711 IEA     GTPase activator activity GO:0005096 IDA     protein binding GO:0005515 IPI     ATP binding GO:0005524 IEA     GTP binding GO:0005525 IDA     GTP binding GO:0005525 TAS     microtubule binding GO:0008017 TAS     tubulin binding GO:0015631 IDA     kinase activity GO:0016301 IDA     kinase activity GO:0016301 IMP     syntaxin-1 binding GO:0017075 IPI     signaling receptor complex adaptor activity GO:0030159 IDA     clathrin binding GO:0030276 IPI     small GTPase binding GO:0031267 IPI     GTP-dependent protein kinase activity GO:0034211 IDA     GTP-dependent protein kinase activity GO:0034211 IMP     histone H3S10 kinase activity GO:0035175 IEA     histone H3T11 kinase activity GO:0035402 IEA     histone H3T6 kinase activity GO:0035403 IEA     histone H2AXS139 kinase activity GO:0035979 IEA     peroxidase inhibitor activity GO:0036479 IDA     co-receptor binding GO:0039706 TAS     identical protein binding GO:0042802 IPI     protein homodimerization activity GO:0042803 IPI     histone H3S28 kinase activity GO:0044022 IEA     histone H4S1 kinase activity GO:0044023 IEA     histone H2AS1 kinase activity GO:0044024 IEA     histone H2BS14 kinase activity GO:0044025 IEA     transmembrane transporter binding GO:0044325 IPI     protein kinase A binding GO:0051018 IPI     histone H3T3 kinase activity GO:0072354 IEA     histone H2AS121 kinase activity GO:0072371 IEA     Rho-dependent protein serine/threonine kinase activity GO:0072518 IEA     protein serine kinase activity GO:0106310 IEA     histone H2BS36 kinase activity GO:0140823 IEA     histone H3S57 kinase activity GO:0140855 IEA     histone H3T45 kinase activity GO:0140857 IEA     beta-catenin destruction complex binding GO:1904713 NAS     histone H2AT120 kinase activity GO:1990244 IEA     membrane scission GTPase motor activity GO:1990606 IEA Biological Process     MAPK cascade GO:0000165 IDA     positive regulation of protein phosphorylation GO:0001934 IDA     positive regulation of protein phosphorylation GO:0001934 IMP     chromatin remodeling GO:0006338 IEA     protein phosphorylation GO:0006468 IMP     protein import into nucleus GO:0006606 IEA     endocytosis GO:0006897 IGI     endocytosis GO:0006897 IMP     autophagy GO:0006914 IEA     response to oxidative stress GO:0006979 IMP     mitochondrion organization GO:0007005 IMP     endoplasmic reticulum organization GO:0007029 IBA     endoplasmic reticulum organization GO:0007029 IMP     Golgi organization GO:0007030 IBA     Golgi organization GO:0007030 IMP     lysosome organization GO:0007040 IMP     JNK cascade GO:0007254 IDA     Rho protein signal transduction GO:0007266 IDA     spermatogenesis GO:0007283 IEA     neuromuscular junction development GO:0007528 IMP     protein localization GO:0008104 ISS     determination of adult lifespan GO:0008340 IMP     cellular response to starvation GO:0009267 IMP     regulation of autophagy GO:0010506 IMP     positive regulation of autophagy GO:0010508 IBA     positive regulation of autophagy GO:0010508 IMP     positive regulation of autophagy GO:0010508 ISS     negative regulation of protein processing GO:0010955 IDA     negative regulation of neuron projection development GO:0010977 IEA     regulation of neuron maturation GO:0014041 IMP     negative regulation of macroautophagy GO:0016242 IMP     phosphorylation GO:0016310 IMP     peptidyl-serine phosphorylation GO:0018105 IDA     peptidyl-threonine phosphorylation GO:0018107 IDA     peptidyl-threonine phosphorylation GO:0018107 IMP     calcium-mediated signaling GO:0019722 IMP     striatum development GO:0021756 IEA     olfactory bulb development GO:0021772 IMP     tangential migration from the subventricular zone to the olfactory bulb GO:0022028 IMP     regulation of cell projection organization GO:0031344 IBA     positive regulation of protein ubiquitination GO:0031398 IDA     regulation of protein stability GO:0031647 IMP     negative regulation of protein binding GO:0032091 IMP     positive regulation of protein binding GO:0032092 IDA     positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 ISS     positive regulation of tumor necrosis factor production GO:0032760 IEA     negative regulation of GTPase activity GO:0034260 IDA     cellular response to oxidative stress GO:0034599 IMP     cellular response to reactive oxygen species GO:0034614 IMP     intracellular signal transduction GO:0035556 IBA     intracellular signal transduction GO:0035556 ISS     regulation of kidney size GO:0035564 ISS     exploration behavior GO:0035640 IMP     locomotory exploration behavior GO:0035641 IEA     regulation of lysosomal lumen pH GO:0035751 IMP     regulation of locomotion GO:0040012 IMP     regulation of membrane potential GO:0042391 IMP     positive regulation of programmed cell death GO:0043068 IDA     positive regulation of MAP kinase activity GO:0043406 IC     positive regulation of MAP kinase activity GO:0043406 IMP     negative regulation of Notch signaling pathway GO:0045746 IEA     positive regulation of protein kinase activity GO:0045860 IDA     GTP metabolic process GO:0046039 IDA     protein autophosphorylation GO:0046777 IDA     protein autophosphorylation GO:0046777 IMP     intracellular distribution of mitochondria GO:0048312 IMP     neuron projection morphogenesis GO:0048812 IMP     mitochondrion localization GO:0051646 IMP     regulation of mitochondrial depolarization GO:0051900 IMP     regulation of synaptic transmission, glutamatergic GO:0051966 ISS     canonical Wnt signaling pathway GO:0060070 TAS     excitatory postsynaptic potential GO:0060079 ISS     regulation of dopamine receptor signaling pathway GO:0060159 IBA     regulation of dopamine receptor signaling pathway GO:0060159 ISS     positive regulation of dopamine receptor signaling pathway GO:0060161 IMP     regulation of ER to Golgi vesicle-mediated transport GO:0060628 ISS     regulation of canonical Wnt signaling pathway GO:0060828 IBA     regulation of canonical Wnt signaling pathway GO:0060828 TAS     regulation of dendritic spine morphogenesis GO:0061001 IMP     regulation of dendritic spine morphogenesis GO:0061001 ISS     protein localization to mitochondrion GO:0070585 TAS     protein localization to endoplasmic reticulum exit site GO:0070973 IMP     cellular response to manganese ion GO:0071287 IMP     regulation of mitochondrial fission GO:0090140 TAS     positive regulation of canonical Wnt signaling pathway GO:0090263 IGI     negative regulation of excitatory postsynaptic potential GO:0090394 ISS     neuron projection arborization GO:0140058 IEA     regulation of cAMP/PKA signal transduction GO:0141161 ISS     regulation of synaptic vesicle endocytosis GO:1900242 IBA     positive regulation of synaptic vesicle endocytosis GO:1900244 IEA     negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway GO:1902236 IMP     positive regulation of protein autoubiquitination GO:1902499 IDA     regulation of neuroblast proliferation GO:1902692 IMP     regulation of synaptic vesicle transport GO:1902803 ISS     regulation of synaptic vesicle transport GO:1902803 TAS     negative regulation of late endosome to lysosome transport GO:1902823 TAS     negative regulation of autophagosome assembly GO:1902902 IMP     negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation GO:1903125 IDA     negative regulation of protein targeting to mitochondrion GO:1903215 IDA     negative regulation of protein processing involved in protein targeting to mitochondrion GO:1903217 IC     cellular response to dopamine GO:1903351 IMP     positive regulation of microglial cell activation GO:1903980 IEA     Wnt signalosome assembly GO:1904887 IPI     Wnt signalosome assembly GO:1904887 TAS     regulation of retrograde transport, endosome to Golgi GO:1905279 IGI     regulation of CAMKK-AMPK signaling cascade GO:1905289 IMP     regulation of branching morphogenesis of a nerve GO:2000172 IMP     regulation of synaptic vesicle exocytosis GO:2000300 IMP     regulation of reactive oxygen species metabolic process GO:2000377 IMP Subcellular Localization     Golgi membrane GO:0000139 IEA     extracellular space GO:0005615 HDA     cytoplasm GO:0005737 IBA     cytoplasm GO:0005737 IDA     cytoplasm GO:0005737 IMP     mitochondrion GO:0005739 IDA     mitochondrial outer membrane GO:0005741 ISS     mitochondrial inner membrane GO:0005743 ISS     mitochondrial matrix GO:0005759 ISS     lysosome GO:0005764 ISS     endosome GO:0005768 ISS     endoplasmic reticulum GO:0005783 IDA     endoplasmic reticulum GO:0005783 ISS     endoplasmic reticulum membrane GO:0005789 IEA     Golgi apparatus GO:0005794 IDA     Golgi apparatus GO:0005794 ISS     Golgi-associated vesicle GO:0005798 IDA     trans-Golgi network GO:0005802 IEA     cytosol GO:0005829 IDA     cytosol GO:0005829 TAS     cytoskeleton GO:0005856 IEA     plasma membrane GO:0005886 IDA     microvillus GO:0005902 IDA     axon GO:0030424 IDA     axon GO:0030424 ISS     dendrite GO:0030425 IDA     dendrite GO:0030425 ISS     growth cone GO:0030426 IDA     synaptic vesicle membrane GO:0030672 IEA     cytoplasmic vesicle GO:0031410 ISS     mitochondrial membrane GO:0031966 IDA     cytoplasmic side of mitochondrial outer membrane GO:0032473 IDA     dendrite cytoplasm GO:0032839 IDA     neuron projection GO:0043005 IDA     neuronal cell body GO:0043025 IDA     terminal bouton GO:0043195 TAS     perikaryon GO:0043204 IDA     perikaryon GO:0043204 ISS     intracellular membrane-bounded organelle GO:0043231 IDA     amphisome GO:0044753 IDA     autolysosome GO:0044754 IDA     phagocytic vesicle GO:0045335 IEA     extracellular exosome GO:0070062 HDA     endoplasmic reticulum exit site GO:0070971 IDA     multivesicular body, internal vesicle GO:0097487 IDA     postsynapse GO:0098794 IEA     glutamatergic synapse GO:0098978 IEA     caveola neck GO:0099400 IDA     presynaptic cytosol GO:0099523 IEA     ribonucleoprotein complex GO:1990904 IEA     Wnt signalosome GO:1990909 IDA     Wnt signalosome GO:1990909 NAS