Gene description for DLC1
Gene name	DLC1 Rho GTPase activating protein
Gene symbol	DLC1
Other names/aliases	ARHGAP7 HP STARD12 p122-RhoGAP
Species	Homo sapiens
Database cross references - DLC1
ExoCarta	ExoCarta_10395
Entrez Gene	10395
HGNC	2897
MIM	604258
UniProt	Q96QB1
DLC1 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells	26054723
Urine	22418980
Urine	22418980

Gene ontology annotations for DLC1

Molecular Function     SH2 domain binding GO:0042169 IPI     protein binding GO:0005515 IPI     GTPase activator activity GO:0005096 IMP     lipid binding GO:0008289 IEA Biological Process     regulation of actin cytoskeleton organization GO:0032956 IMP     apoptotic process GO:0006915 IDA     forebrain development GO:0030900 ISS     positive regulation of GTPase activity GO:0043547 IMP     neural tube closure GO:0001843 ISS     negative regulation of Rho protein signal transduction GO:0035024 IMP     focal adhesion assembly GO:0048041 ISS     actin cytoskeleton organization GO:0030036 ISS     positive regulation of execution phase of apoptosis GO:1900119 IDA     activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 IDA     regulation of small GTPase mediated signal transduction GO:0051056 TAS     positive regulation of protein dephosphorylation GO:0035307 IDA     negative regulation of cell migration GO:0030336 IMP     negative regulation of focal adhesion assembly GO:0051895 IDA     negative regulation of stress fiber assembly GO:0051497 IDA     small GTPase mediated signal transduction GO:0007264 TAS     regulation of cell shape GO:0008360 IMP     hindbrain morphogenesis GO:0021575 ISS     heart morphogenesis GO:0003007 ISS     negative regulation of cell proliferation GO:0008285 IMP Subcellular Localization     ruffle membrane GO:0032587 IDA     nucleus GO:0005634 IDA     focal adhesion GO:0005925 IDA     cytoplasm GO:0005737 IDA     cytosol GO:0005829 TAS     cortical actin cytoskeleton GO:0030864 IDA     caveola GO:0005901 IDA