Gene description for MAP3K11
Gene name mitogen-activated protein kinase kinase kinase 11
Gene symbol MAP3K11
Other names/aliases MEKK11
MLK-3
MLK3
PTK1
SPRK
Species Homo sapiens
 Database cross references - MAP3K11
ExoCarta ExoCarta_4296
Entrez Gene 4296
HGNC 6850
MIM 600050
UniProt Q16584  
 MAP3K11 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for MAP3K11
Molecular Function
    JUN kinase kinase kinase activity GO:0004706 ISS
    protein tyrosine kinase activity GO:0004713 IEA
    protein binding GO:0005515 IPI
    protein kinase activity GO:0004672 TAS
    Rac GTPase binding GO:0048365 IEA
    identical protein binding GO:0042802 IPI
    protein serine/threonine kinase activity GO:0004674 IDA
    mitogen-activated protein kinase kinase binding GO:0031434 IEA
    protein homodimerization activity GO:0042803 IPI
    mitogen-activated protein kinase kinase kinase binding GO:0031435 IPI
    ATP binding GO:0005524 IEA
Biological Process
    peptidyl-tyrosine phosphorylation GO:0018108 IEA
    cell death GO:0008219 IEA
    activation of MAPK activity GO:0000187 IMP
    positive regulation of neuron apoptotic process GO:0043525 IEA
    protein autophosphorylation GO:0046777 IDA
    JNK cascade GO:0007254 TAS
    positive regulation of JUN kinase activity GO:0043507 IMP
    microtubule-based process GO:0007017 IMP
    protein phosphorylation GO:0006468 IDA
    positive regulation of JNK cascade GO:0046330 IMP
    activation of JNKK activity GO:0007256 IEA
    activation of JUN kinase activity GO:0007257 IMP
    cell proliferation GO:0008283 IMP
Subcellular Localization
    membrane GO:0016020 IDA
    microtubule GO:0005874 IDA
    cytoplasm GO:0005737 IEA
    centrosome GO:0005813 IDA
 Experiment description of studies that identified MAP3K11 in exosomes
1
Experiment ID 237
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for MAP3K11
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MAP2K7 5609
Invitro Homo sapiens
Invivo Homo sapiens
2 KIF3B 9371
Two-hybrid Homo sapiens
3 CDC42 998
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
4 MAPK8IP1 9479
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
5 KIF3A 11127
Two-hybrid Homo sapiens
6 RHOG 391
Reconstituted Complex Homo sapiens
7 AKT1 207
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
8 IKBKB 3551
Invivo Homo sapiens
9 MAP3K12  
Invitro Homo sapiens
Invivo Homo sapiens
10 CHUK 1147
Invivo Homo sapiens
11 KIF17 57576
Two-hybrid Homo sapiens
12 KIFAP3  
Two-hybrid Homo sapiens
13 MAPK8IP3  
Invivo Homo sapiens
Invitro Homo sapiens
14 MAPK8IP2  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
15 SH3MD2  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
16 MAP4K1  
Biochemical Activity Homo sapiens
View the network image/svg+xml
 Pathways in which MAP3K11 is involved
No pathways found





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