Gene description for PLEKHO1
Gene name pleckstrin homology domain containing, family O member 1
Gene symbol PLEKHO1
Other names/aliases CKIP-1
JBP
OC120
Species Homo sapiens
 Database cross references - PLEKHO1
ExoCarta ExoCarta_51177
Vesiclepedia VP_51177
Entrez Gene 51177
HGNC 24310
MIM 608335
UniProt Q53GL0  
 PLEKHO1 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for PLEKHO1
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    myoblast fusion GO:0007520 IEA
    regulation of cell shape GO:0008360 IEA
    myoblast migration GO:0051451 IEA
    lamellipodium morphogenesis GO:0072673 IEA
    regulation of myoblast fusion GO:1901739 IBA
Subcellular Localization
    nucleus GO:0005634 IEA
    cytoplasm GO:0005737 IEA
    ruffle membrane GO:0032587 IBA
    muscle cell projection membrane GO:0036195 IBA
 Experiment description of studies that identified PLEKHO1 in exosomes
1
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for PLEKHO1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 WDR45B 56270
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 KBTBD7  
Affinity Capture-MS Homo sapiens
3 SMAD5 4090
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
4 DOK2 9046
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 RPL26L1 51121
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 TRMT1L 81627
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 PPAN-P2RY11  
Affinity Capture-MS Homo sapiens
8 USP7 7874
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
9 NOC3L 64318
Affinity Capture-MS Homo sapiens
10 CCNB1 891
Negative Genetic Homo sapiens
11 CCDC114  
Affinity Capture-MS Homo sapiens
12 SMURF1 57154
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
13 NLE1 54475
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 RPS20 6224
Two-hybrid Homo sapiens
15 GTPBP10  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 SEC24D 9871
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 DDX31  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 Stub1 56424
Two-hybrid Mus musculus
19 NMNAT1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 TRAF6 7189
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
21 CAPZA2 830
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 URB1 9875
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 AKT3  
Affinity Capture-Western Homo sapiens
24 CSNK2A1 1457
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
25 GLYR1 84656
Affinity Capture-MS Homo sapiens
26 PLEKHO1 51177
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
27 RBM28 55131
Affinity Capture-MS Homo sapiens
28 CENPV 201161
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 SUPT5H 6829
Affinity Capture-MS Homo sapiens
30 PDCD11 22984
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 NVL  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 STAU1 6780
Affinity Capture-MS Homo sapiens
33 RPL5 6125
Affinity Capture-MS Homo sapiens
34 RPL3 6122
Affinity Capture-MS Homo sapiens
35 AMY1C 278
Affinity Capture-MS Homo sapiens
36 CAPZB 832
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 Arpc1a 56443
Two-hybrid Mus musculus
38 C10orf88  
Two-hybrid Homo sapiens
39 FXR1 8087
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 IFI35 3430
Two-hybrid Homo sapiens
41 GTPBP2 54676
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 OGT 8473
Reconstituted Complex Homo sapiens
43 Rps3a1 20091
Two-hybrid Mus musculus
44 AKT2 208
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
45 FLNC 2318
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 PSMC5 5705
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
47 FLNB 2317
Two-hybrid Homo sapiens
48 MYBBP1A 10514
Affinity Capture-MS Homo sapiens
49 CAPZA1 829
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 NOC2L 26155
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 SDAD1  
Affinity Capture-MS Homo sapiens
52 UBA6 55236
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 AKT1 207
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
54 DNAJB1 3337
Two-hybrid Homo sapiens
55 SPTY2D1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 FTSJ3 117246
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 DDX51  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which PLEKHO1 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here