Gene description for CHUK
Gene name	conserved helix-loop-helix ubiquitous kinase
Gene symbol	CHUK
Other names/aliases	IKBKA IKK-alpha IKK1 IKKA NFKBIKA TCF16
Species	Homo sapiens
Database cross references - CHUK
ExoCarta	ExoCarta_1147
Entrez Gene	1147
HGNC	1974
MIM	600664
UniProt	O15111
CHUK identified in exosomes derived from the following tissue/cell type
Thymus	23844026

Gene ontology annotations for CHUK

Molecular Function     protein homodimerization activity GO:0042803 IDA     scaffold protein binding GO:0097110 IDA     IkappaB kinase activity GO:0008384 TAS     protein binding GO:0005515 IPI     ATP binding GO:0005524 IEA     protein kinase activity GO:0004672 IDA     protein heterodimerization activity GO:0046982 IDA Biological Process     inflammatory response GO:0006954 TAS     MyD88-dependent toll-like receptor signaling pathway GO:0002755 TAS     nucleotide-binding oligomerization domain containing signaling pathway GO:0070423 TAS     striated muscle cell differentiation GO:0051146 IEA     lactation GO:0007595 IEA     toll-like receptor 9 signaling pathway GO:0034162 TAS     response to drug GO:0042493 IEA     mammary gland alveolus development GO:0060749 IEA     I-kappaB kinase/NF-kappaB signaling GO:0007249 TAS     T cell receptor signaling pathway GO:0050852 TAS     fibroblast growth factor receptor signaling pathway GO:0008543 TAS     toll-like receptor signaling pathway GO:0002224 TAS     toll-like receptor 2 signaling pathway GO:0034134 TAS     innate immune response GO:0045087 TAS     odontogenesis of dentin-containing tooth GO:0042475 IEA     response to hydroperoxide GO:0033194 IEA     toll-like receptor TLR6:TLR2 signaling pathway GO:0038124 TAS     response to toxic substance GO:0009636 IEA     Rho protein signal transduction GO:0007266 IEA     response to amino acid GO:0043200 IEA     anatomical structure morphogenesis GO:0009653 TAS     skeletal muscle contraction GO:0003009 IEA     epidermal growth factor receptor signaling pathway GO:0007173 TAS     I-kappaB phosphorylation GO:0007252 TAS     toll-like receptor 5 signaling pathway GO:0034146 TAS     MyD88-independent toll-like receptor signaling pathway GO:0002756 TAS     immune response GO:0006955 TAS     Fc-epsilon receptor signaling pathway GO:0038095 TAS     positive regulation of transcription from RNA polymerase II promoter GO:0045944 IDA     mammary gland epithelial cell proliferation GO:0033598 IEA     phosphatidylinositol-mediated signaling GO:0048015 TAS     toll-like receptor 10 signaling pathway GO:0034166 TAS     positive regulation of type I interferon production GO:0032481 TAS     TRIF-dependent toll-like receptor signaling pathway GO:0035666 TAS     toll-like receptor 3 signaling pathway GO:0034138 TAS     positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 TAS     toll-like receptor 4 signaling pathway GO:0034142 TAS     cellular response to tumor necrosis factor GO:0071356 IDA     neurotrophin TRK receptor signaling pathway GO:0048011 TAS     stimulatory C-type lectin receptor signaling pathway GO:0002223 TAS     response to virus GO:0009615 TAS     toll-like receptor TLR1:TLR2 signaling pathway GO:0038123 TAS     protein phosphorylation GO:0006468 IDA     morphogenesis of an epithelial sheet GO:0002011 IEA     nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway GO:0035872 TAS     response to lipopolysaccharide GO:0032496 IEA     osteoclast differentiation GO:0030316 IEA     positive regulation of NF-kappaB transcription factor activity GO:0051092 TAS Subcellular Localization     cytoplasmic side of plasma membrane GO:0009898 ISS     cytoplasm GO:0005737 IDA     IkappaB kinase complex GO:0008385 TAS     cytosol GO:0005829 TAS     nucleoplasm GO:0005654 IDA     intracellular membrane-bounded organelle GO:0043231 IDA     CD40 receptor complex GO:0035631 ISS