Gene description for TRAF6
Gene name	TNF receptor-associated factor 6, E3 ubiquitin protein ligase
Gene symbol	TRAF6
Other names/aliases	MGC:3310 RNF85
Species	Homo sapiens
Database cross references - TRAF6
ExoCarta	ExoCarta_7189
Entrez Gene	7189
HGNC	12036
MIM	602355
UniProt	Q9Y4K3
TRAF6 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells	26054723

Gene ontology annotations for TRAF6

Molecular Function     mitogen-activated protein kinase kinase kinase binding GO:0031435 IPI     thioesterase binding GO:0031996 IPI     ligase activity GO:0016874 IEA     tumor necrosis factor receptor binding GO:0005164 IPI     protein kinase binding GO:0019901 IPI     ubiquitin-protein transferase activity GO:0004842 TAS     protein binding GO:0005515 IPI     identical protein binding GO:0042802 IPI     ubiquitin conjugating enzyme binding GO:0031624 IDA     zinc ion binding GO:0008270 IEA     ubiquitin protein ligase binding GO:0031625 IPI     protein kinase B binding GO:0043422 IPI     histone deacetylase binding GO:0042826 IPI     protein N-terminus binding GO:0047485 IPI Biological Process     protein K63-linked ubiquitination GO:0070534 IGI     positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 TAS     apoptotic signaling pathway GO:0097190 TAS     myeloid dendritic cell differentiation GO:0043011 IEA     positive regulation of transcription regulatory region DNA binding GO:2000679 IDA     toll-like receptor TLR1:TLR2 signaling pathway GO:0038123 TAS     T cell receptor signaling pathway GO:0050852 TAS     antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 IEA     cell development GO:0048468 IEA     neural tube closure GO:0001843 IEA     odontogenesis of dentin-containing tooth GO:0042475 IEA     positive regulation of protein ubiquitination GO:0031398 NAS     regulation of immunoglobulin secretion GO:0051023 IEA     toll-like receptor signaling pathway GO:0002224 TAS     positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 IMP     osteoclast differentiation GO:0030316 IEA     positive regulation of JUN kinase activity GO:0043507 NAS     positive regulation of interleukin-6 biosynthetic process GO:0045410 IEA     negative regulation of apoptotic process GO:0043066 TAS     Fc-epsilon receptor signaling pathway GO:0038095 TAS     neurotrophin TRK receptor signaling pathway GO:0048011 TAS     positive regulation of transcription from RNA polymerase II promoter GO:0045944 NAS     activation of NF-kappaB-inducing kinase activity GO:0007250 IMP     protein polyubiquitination GO:0000209 IDA     toll-like receptor 9 signaling pathway GO:0034162 TAS     TRIF-dependent toll-like receptor signaling pathway GO:0035666 TAS     nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway GO:0035872 TAS     positive regulation of NF-kappaB transcription factor activity GO:0051092 TAS     stimulatory C-type lectin receptor signaling pathway GO:0002223 TAS     toll-like receptor 5 signaling pathway GO:0034146 TAS     activation of MAPK activity GO:0000187 TAS     positive regulation of interleukin-12 biosynthetic process GO:0045084 IEA     activation of protein kinase activity GO:0032147 IDA     T-helper 1 type immune response GO:0042088 IEA     positive regulation of T cell activation GO:0050870 IC     positive regulation of lipopolysaccharide-mediated signaling pathway GO:0031666 IEA     positive regulation of T cell proliferation GO:0042102 IEA     ossification GO:0001503 IEA     negative regulation of transcription, DNA-templated GO:0045892 IMP     interleukin-1-mediated signaling pathway GO:0070498 IEA     positive regulation of smooth muscle cell proliferation GO:0048661 IEA     bone resorption GO:0045453 IEA     positive regulation of interleukin-2 production GO:0032743 IMP     toll-like receptor 3 signaling pathway GO:0034138 TAS     positive regulation of osteoclast differentiation GO:0045672 IDA     innate immune response GO:0045087 TAS     response to interleukin-1 GO:0070555 IDA     JNK cascade GO:0007254 TAS     protein autoubiquitination GO:0051865 TAS     toll-like receptor 10 signaling pathway GO:0034166 TAS     membrane protein intracellular domain proteolysis GO:0031293 TAS     cellular response to lipopolysaccharide GO:0071222 IDA     toll-like receptor TLR6:TLR2 signaling pathway GO:0038124 TAS     toll-like receptor 4 signaling pathway GO:0034142 TAS     negative regulation of transcription from RNA polymerase II promoter GO:0000122 IMP     stress-activated MAPK cascade GO:0051403 TAS     MyD88-dependent toll-like receptor signaling pathway GO:0002755 TAS     toll-like receptor 2 signaling pathway GO:0034134 TAS     protein complex assembly GO:0006461 IEA     nucleotide-binding oligomerization domain containing signaling pathway GO:0070423 TAS     positive regulation of T cell cytokine production GO:0002726 IMP     positive regulation of apoptotic process GO:0043065 TAS     I-kappaB kinase/NF-kappaB signaling GO:0007249 TAS     MyD88-independent toll-like receptor signaling pathway GO:0002756 TAS Subcellular Localization     CD40 receptor complex GO:0035631 ISS     cytosol GO:0005829 TAS     cytoplasm GO:0005737 IDA     cytoplasmic side of plasma membrane GO:0009898 ISS     lipid particle GO:0005811 ISS     perinuclear region of cytoplasm GO:0048471 IDA     endosome membrane GO:0010008 TAS     nucleus GO:0005634 IDA     plasma membrane GO:0005886 TAS     mitochondrion GO:0005739 IDA     cell cortex GO:0005938 IEA     nucleolus GO:0005730 IDA     protein complex GO:0043234 IDA