Gene description for TRAF6
Gene name	TNF receptor-associated factor 6, E3 ubiquitin protein ligase
Gene symbol	TRAF6
Other names/aliases	MGC:3310 RNF85
Species	Homo sapiens
Database cross references - TRAF6
ExoCarta	ExoCarta_7189
Vesiclepedia	VP_7189
Entrez Gene	7189
HGNC	12036
MIM	602355
UniProt	Q9Y4K3
TRAF6 identified in sEVs derived from the following tissue/cell type
Hepatocellular carcinoma cells	26054723

Gene ontology annotations for TRAF6

Molecular Function     ubiquitin-protein transferase activity GO:0004842 EXP     ubiquitin-protein transferase activity GO:0004842 TAS     tumor necrosis factor receptor binding GO:0005164 IEA     protein binding GO:0005515 IPI     zinc ion binding GO:0008270 IEA     protein-macromolecule adaptor activity GO:0030674 IDA     ubiquitin conjugating enzyme binding GO:0031624 IDA     ubiquitin-ubiquitin ligase activity GO:0034450 IDA     signaling adaptor activity GO:0035591 IBA     identical protein binding GO:0042802 IPI     histone deacetylase binding GO:0042826 IPI     protein kinase B binding GO:0043422 IPI     ubiquitin protein ligase activity GO:0061630 IBA     ubiquitin protein ligase activity GO:0061630 IDA Biological Process     autophagosome assembly GO:0000045 IDA     negative regulation of transcription by RNA polymerase II GO:0000122 IMP     protein polyubiquitination GO:0000209 IDA     ossification GO:0001503 IEA     in utero embryonic development GO:0001701 IEA     neural tube closure GO:0001843 IEA     stimulatory C-type lectin receptor signaling pathway GO:0002223 TAS     regulation of immunoglobulin production GO:0002637 IEA     positive regulation of T cell cytokine production GO:0002726 IMP     cytoplasmic pattern recognition receptor signaling pathway GO:0002753 IDA     cytoplasmic pattern recognition receptor signaling pathway GO:0002753 TAS     MyD88-dependent toll-like receptor signaling pathway GO:0002755 TAS     DNA damage response GO:0006974 IEA     canonical NF-kappaB signal transduction GO:0007249 IDA     canonical NF-kappaB signal transduction GO:0007249 IMP     canonical NF-kappaB signal transduction GO:0007249 TAS     antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 IEA     CD40 signaling pathway GO:0023035 IDA     osteoclast differentiation GO:0030316 IEA     positive regulation of protein ubiquitination GO:0031398 NAS     lipopolysaccharide-mediated signaling pathway GO:0031663 IBA     positive regulation of lipopolysaccharide-mediated signaling pathway GO:0031666 IEA     activation of protein kinase activity GO:0032147 IDA     positive regulation of type I interferon production GO:0032481 IEA     positive regulation of interleukin-12 production GO:0032735 IEA     positive regulation of interleukin-2 production GO:0032743 IMP     positive regulation of interleukin-6 production GO:0032755 IEA     toll-like receptor 3 signaling pathway GO:0034138 TAS     toll-like receptor 4 signaling pathway GO:0034142 IDA     TRIF-dependent toll-like receptor signaling pathway GO:0035666 TAS     non-canonical NF-kappaB signal transduction GO:0038061 IDA     Fc-epsilon receptor signaling pathway GO:0038095 TAS     interleukin-33-mediated signaling pathway GO:0038172 IMP     interleukin-17A-mediated signaling pathway GO:0038173 IDA     T-helper 1 type immune response GO:0042088 IEA     positive regulation of T cell proliferation GO:0042102 IEA     odontogenesis of dentin-containing tooth GO:0042475 IEA     regulation of apoptotic process GO:0042981 IEA     myeloid dendritic cell differentiation GO:0043011 IEA     regulation of canonical NF-kappaB signal transduction GO:0043122 IBA     positive regulation of canonical NF-kappaB signal transduction GO:0043123 IDA     positive regulation of JUN kinase activity GO:0043507 IDA     positive regulation of JUN kinase activity GO:0043507 NAS     innate immune response GO:0045087 IBA     bone resorption GO:0045453 IEA     positive regulation of osteoclast differentiation GO:0045672 IDA     negative regulation of DNA-templated transcription GO:0045892 IMP     positive regulation of transcription by RNA polymerase II GO:0045944 IDA     positive regulation of transcription by RNA polymerase II GO:0045944 NAS     T cell receptor signaling pathway GO:0050852 IDA     T cell receptor signaling pathway GO:0050852 IMP     T cell receptor signaling pathway GO:0050852 TAS     positive regulation of DNA-binding transcription factor activity GO:0051091 IMP     positive regulation of NF-kappaB transcription factor activity GO:0051092 IDA     positive regulation of NF-kappaB transcription factor activity GO:0051092 IMP     protein autoubiquitination GO:0051865 IDA     protein autoubiquitination GO:0051865 IDA     protein autoubiquitination GO:0051865 TAS     interleukin-1-mediated signaling pathway GO:0070498 TAS     protein K63-linked ubiquitination GO:0070534 IDA     protein K63-linked ubiquitination GO:0070534 IGI     response to interleukin-1 GO:0070555 IDA     cellular response to lipopolysaccharide GO:0071222 IDA     cellular response to cytokine stimulus GO:0071345 IMP     interleukin-17-mediated signaling pathway GO:0097400 IEA     regulation of neurotransmitter receptor localization to postsynaptic specialization membrane GO:0098696 IEA     antiviral innate immune response GO:0140374 IDA     protein branched polyubiquitination GO:0141198 IDA     positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 IMP     positive regulation of transcription regulatory region DNA binding GO:2000679 IDA Subcellular Localization     nucleus GO:0005634 IDA     cytoplasm GO:0005737 IBA     cytoplasm GO:0005737 IC     cytoplasm GO:0005737 IDA     cytoplasm GO:0005737 IDA     lipid droplet GO:0005811 ISS     cytosol GO:0005829 TAS     plasma membrane GO:0005886 IDA     plasma membrane GO:0005886 TAS     cell cortex GO:0005938 IEA     cytoplasmic side of plasma membrane GO:0009898 ISS     endosome membrane GO:0010008 TAS     extrinsic component of cytoplasmic side of plasma membrane GO:0031234 IC     protein-containing complex GO:0032991 IDA     CD40 receptor complex GO:0035631 ISS     perinuclear region of cytoplasm GO:0048471 IDA     plasma membrane signaling receptor complex GO:0098802 IBA     glutamatergic synapse GO:0098978 IEA