Gene description for PRDM16
Gene name PR domain containing 16
Gene symbol PRDM16
Other names/aliases CMD1LL
LVNC8
MEL1
PFM13
Species Homo sapiens
 Database cross references - PRDM16
ExoCarta ExoCarta_63976
Entrez Gene 63976
HGNC 14000
MIM 605557
UniProt Q9HAZ2  
 PRDM16 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for PRDM16
Molecular Function
    SMAD binding GO:0046332 IEA
    protein binding GO:0005515 IPI
    transcription coactivator activity GO:0003713 ISS
    activating transcription factor binding GO:0033613 IPI
    metal ion binding GO:0046872 IEA
    sequence-specific DNA binding GO:0043565 IDA
Biological Process
    tongue development GO:0043586 IEA
    regulation of cellular respiration GO:0043457 ISS
    neurogenesis GO:0022008 IEA
    palate development GO:0060021 IEA
    negative regulation of transcription, DNA-templated GO:0045892 ISS
    somatic stem cell maintenance GO:0035019 IEA
    white fat cell differentiation GO:0050872 IEA
    brown fat cell differentiation GO:0050873 ISS
    chromatin organization GO:0006325 TAS
    transcription, DNA-templated GO:0006351 IEA
    negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 IMP
    negative regulation of granulocyte differentiation GO:0030853 IDA
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IDA
    positive regulation of transcription, DNA-templated GO:0045893 ISS
Subcellular Localization
    cytosol GO:0005829 TAS
    transcriptional repressor complex GO:0017053 ISS
    nucleus GO:0005634 IDA
 Experiment description of studies that identified PRDM16 in exosomes
1
Experiment ID 126
ISEV standards
EV Biophysical techniques
GAPDH
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for PRDM16
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which PRDM16 is involved
PathwayEvidenceSource
PKMTs methylate histone lysines TAS Reactome





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