Gene description for C10orf54
Gene name chromosome 10 open reading frame 54
Gene symbol C10orf54
Other names/aliases B7-H5
B7H5
GI24
PP2135
SISP1
Species Homo sapiens
 Database cross references - C10orf54
ExoCarta ExoCarta_64115
Vesiclepedia VP_64115
Entrez Gene 64115
HGNC 30085
MIM 615608
UniProt Q9H7M9  
 C10orf54 identified in sEVs derived from the following tissue/cell type
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
 Gene ontology annotations for C10orf54
Molecular Function
    protein binding GO:0005515 IPI
    enzyme binding GO:0019899 IPI
    identical protein binding GO:0042802 IPI
    endopeptidase activator activity GO:0061133 IDA
Biological Process
    positive regulation of gene expression GO:0010628 IMP
    positive regulation of endopeptidase activity GO:0010950 IDA
    positive regulation of cell migration GO:0030335 IDA
    zymogen activation GO:0031638 IDA
    negative regulation of type II interferon production GO:0032689 IDA
    negative regulation of interleukin-10 production GO:0032693 IDA
    negative regulation of interleukin-17 production GO:0032700 IDA
    negative regulation of tumor necrosis factor production GO:0032720 IDA
    positive regulation of regulatory T cell differentiation GO:0045591 IMP
    negative regulation of alpha-beta T cell activation GO:0046636 IBA
    regulation of immune response GO:0050776 IEA
    positive regulation of collagen catabolic process GO:0120158 IDA
    negative regulation of CD4-positive, alpha-beta T cell proliferation GO:2000562 IMP
    negative regulation of CD8-positive, alpha-beta T cell proliferation GO:2000565 IMP
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
 Experiment description of studies that identified C10orf54 in sEVs
1
Experiment ID 231
MISEV standards
Biophysical techniques
Alix|CD63|CD9
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 232
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 233
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for C10orf54
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
2 TMEM14C 51522
Two-hybrid Homo sapiens
3 BMP10  
Two-hybrid Homo sapiens
4 ASGR1 432
Two-hybrid Homo sapiens
5 SLC35B1 10237
Two-hybrid Homo sapiens
6 TNF  
Two-hybrid Homo sapiens
7 SLC35B4  
Two-hybrid Homo sapiens
8 PLSCR1 5359
Two-hybrid Homo sapiens
9 CLEC7A  
Two-hybrid Homo sapiens
10 CCL4L2  
Two-hybrid Homo sapiens
11 APOD 347
Two-hybrid Homo sapiens
12 TMEM100 55273
Two-hybrid Homo sapiens
13 TSPAN2 10100
Two-hybrid Homo sapiens
14 ATP6V0C 527
Two-hybrid Homo sapiens
15 TMEM229B  
Two-hybrid Homo sapiens
16 SMAD3 4088
Two-hybrid Homo sapiens
17 DOLK 22845
Two-hybrid Homo sapiens
18 SMCO4  
Two-hybrid Homo sapiens
19 PPAPDC2  
Two-hybrid Homo sapiens
20 C14orf180  
Two-hybrid Homo sapiens
21 LPPR2  
Two-hybrid Homo sapiens
22 CNIH3  
Two-hybrid Homo sapiens
23 TSPO2  
Two-hybrid Homo sapiens
24 MS4A13  
Two-hybrid Homo sapiens
25 TMEM97 27346
Two-hybrid Homo sapiens
26 CLRN2  
Two-hybrid Homo sapiens
27 TMEM218  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which C10orf54 is involved
No pathways found





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