Gene description for MEN1
Gene name multiple endocrine neoplasia I
Gene symbol MEN1
Other names/aliases MEAI
SCG2
Species Homo sapiens
 Database cross references - MEN1
ExoCarta ExoCarta_4221
Entrez Gene 4221
HGNC 7010
MIM 613733
UniProt O00255  
 MEN1 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for MEN1
Molecular Function
    Y-form DNA binding GO:0000403 IDA
    double-stranded DNA binding GO:0003690 IDA
    four-way junction DNA binding GO:0000400 IDA
    sequence-specific DNA binding GO:0043565 IEA
    chromatin binding GO:0003682 IBA
    histone-lysine N-methyltransferase activity GO:0018024 IDA
    protein binding, bridging GO:0030674 IDA
    protein N-terminus binding GO:0047485 IPI
    transcription regulatory region DNA binding GO:0044212 IDA
    R-SMAD binding GO:0070412 IPI
    protein binding GO:0005515 IPI
Biological Process
    negative regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045736 IMP
    cell cycle arrest GO:0007050 IEA
    leukocyte homeostasis GO:0001776 IEA
    DNA repair GO:0006281 NAS
    negative regulation of transcription, DNA-templated GO:0045892 IDA
    positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 IMP
    negative regulation of sequence-specific DNA binding transcription factor activity GO:0043433 IDA
    MAPK cascade GO:0000165 IDA
    positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280 IEA
    transcription, DNA-templated GO:0006351 TAS
    maternal process involved in female pregnancy GO:0060135 IEA
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 TAS
    positive regulation of osteoblast differentiation GO:0045669 IEA
    response to gamma radiation GO:0010332 IDA
    histone lysine methylation GO:0034968 IDA
    negative regulation of telomerase activity GO:0051974 IMP
    small GTPase mediated signal transduction GO:0007264 TAS
    negative regulation of organ growth GO:0046621 IEA
    transcription initiation from RNA polymerase II promoter GO:0006367 TAS
    chromatin remodeling GO:0006338 IEA
    cellular response to DNA damage stimulus GO:0006974 IDA
    negative regulation of cell proliferation GO:0008285 IDA
    negative regulation of protein phosphorylation GO:0001933 IDA
    osteoblast development GO:0002076 IGI
    regulation of activin receptor signaling pathway GO:0032925 IEA
    hemopoiesis GO:0030097 IEA
    brain development GO:0007420 IEA
    gene expression GO:0010467 TAS
    positive regulation of protein binding GO:0032092 IDA
    positive regulation of cell division GO:0051781 IEA
    response to UV GO:0009411 IDA
    negative regulation of cell cycle GO:0045786 IDA
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IDA
    palate development GO:0060021 IEA
    embryonic skeletal system morphogenesis GO:0048704 IEA
    positive regulation of histone methylation GO:0031062 IEA
    transforming growth factor beta receptor signaling pathway GO:0007179 TAS
    negative regulation of osteoblast differentiation GO:0045668 IGI
    osteoblast fate commitment GO:0002051 IEA
    negative regulation of JNK cascade GO:0046329 IDA
Subcellular Localization
    protein complex GO:0043234 IDA
    chromatin GO:0000785 IDA
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IDA
    nucleus GO:0005634 IDA
    cytosol GO:0005829 TAS
    cleavage furrow GO:0032154 IDA
    histone methyltransferase complex GO:0035097 IPI
    nuclear matrix GO:0016363 IDA
 Experiment description of studies that identified MEN1 in exosomes
1
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for MEN1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ASH2L  
Reconstituted Complex Homo sapiens
2 NFKB1 4790
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
3 RPA2 6118
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
4 HCFC1 3054
Co-purification Homo sapiens
5 GFAP 2670
Invivo Homo sapiens
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
6 RELA  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
7 JUND 3727
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
8 WDR5 11091
Co-purification Homo sapiens
9 VIM 7431
Invivo Homo sapiens
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
10 NFKB2 4791
Reconstituted Complex Homo sapiens
11 SMAD3  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
12 HCFC2  
Co-purification Homo sapiens
13 FANCD2  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
14 MLL  
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
15 RPRM  
Affinity Capture-MS Homo sapiens
16 RBBP5  
Co-purification Homo sapiens
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