Gene description for GGA1
Gene name golgi-associated, gamma adaptin ear containing, ARF binding protein 1
Gene symbol GGA1
Other names/aliases -
Species Homo sapiens
 Database cross references - GGA1
ExoCarta ExoCarta_26088
Entrez Gene 26088
HGNC 17842
MIM 606004
UniProt Q9UJY5  
 GGA1 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for GGA1
Molecular Function
    molecular_function GO:0003674 ND
    protein binding GO:0005515 IPI
Biological Process
    vesicle-mediated transport GO:0016192 IEA
    positive regulation of protein catabolic process GO:0045732 IEA
    intracellular protein transport GO:0006886 TAS
Subcellular Localization
    endosome membrane GO:0010008 IEA
    Golgi apparatus GO:0005794 TAS
    membrane GO:0016020 IDA
    nucleoplasm GO:0005654 IDA
    clathrin adaptor complex GO:0030131 IEA
    intracellular membrane-bounded organelle GO:0043231 IDA
 Experiment description of studies that identified GGA1 in exosomes
Experiment ID 224
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for GGA1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SYNRG 11276
Two-hybrid Homo sapiens
2 NECAP2  
Affinity Capture-Western Homo sapiens
3 M6PR 4074
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
4 CLTC 1213
Reconstituted Complex Homo sapiens
5 ARF3 377
Two-hybrid Homo sapiens
6 RABEP1  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
7 SORL1 6653
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
9 RAB5A 5868
Two-hybrid Homo sapiens
10 ARF1 375
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which GGA1 is involved
No pathways found

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