Gene description for UBQLN4
Gene name ubiquilin 4
Gene symbol UBQLN4
Other names/aliases A1U
A1Up
C1orf6
CIP75
UBIN
Species Homo sapiens
 Database cross references - UBQLN4
ExoCarta ExoCarta_56893
Vesiclepedia VP_56893
Entrez Gene 56893
HGNC 1237
MIM 605440
UniProt Q9NRR5  
 UBQLN4 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Thymus 23844026    
 Gene ontology annotations for UBQLN4
Molecular Function
    protein binding GO:0005515 IPI
    polyubiquitin modification-dependent protein binding GO:0031593 IBA
    polyubiquitin modification-dependent protein binding GO:0031593 IDA
    polyubiquitin modification-dependent protein binding GO:0031593 IPI
    K48-linked polyubiquitin modification-dependent protein binding GO:0036435 IDA
    identical protein binding GO:0042802 IPI
Biological Process
    DNA repair GO:0006281 IEA
    ubiquitin-dependent protein catabolic process GO:0006511 IBA
    autophagy GO:0006914 IEA
    DNA damage response GO:0006974 IDA
    regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 IDA
    regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 IMP
    negative regulation of autophagosome maturation GO:1901097 IMP
    negative regulation of double-strand break repair via homologous recombination GO:2000042 IDA
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IDA
    autophagosome GO:0005776 IDA
    endoplasmic reticulum membrane GO:0005789 ISS
    cytosol GO:0005829 IBA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 ISS
    cytoplasmic vesicle GO:0031410 IEA
    nuclear proteasome complex GO:0031595 IDA
    cytosolic proteasome complex GO:0031597 IDA
    protein-containing complex GO:0032991 IDA
    perinuclear region of cytoplasm GO:0048471 IEA
    site of DNA damage GO:0090734 IDA
 Experiment description of studies that identified UBQLN4 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 217
MISEV standards
EM
Biophysical techniques
TSG101|CD81|CD9|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for UBQLN4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 OR2M7  
Affinity Capture-MS Homo sapiens
2 SCAF1  
Two-hybrid Homo sapiens
3 HIST2H2BE 8349
Affinity Capture-MS Homo sapiens
4 CDSN 1041
Two-hybrid Homo sapiens
5 BPIFA1 51297
Two-hybrid Homo sapiens
6 ZG16  
Two-hybrid Homo sapiens
7 CBX1 10951
Affinity Capture-MS Homo sapiens
8 SLC5A10 125206
Affinity Capture-MS Homo sapiens
9 STK25 10494
Affinity Capture-MS Homo sapiens
10 HDAC2 3066
Affinity Capture-MS Homo sapiens
11 UBE2A  
Co-fractionation Homo sapiens
12 CD99 4267
Two-hybrid Homo sapiens
13 FKBP7 51661
Two-hybrid Homo sapiens
14 ZBTB22  
Two-hybrid Homo sapiens
15 GJA1 2697
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
16 MYEOV  
Affinity Capture-MS Homo sapiens
17 NOTCH2NL 388677
Two-hybrid Homo sapiens
18 FA2H  
Two-hybrid Homo sapiens
19 ITPRIPL1  
Two-hybrid Homo sapiens
20 DKK3 27122
Two-hybrid Homo sapiens
21 PCDH8  
Two-hybrid Homo sapiens
22 IGHM 3507
Two-hybrid Homo sapiens
23 HSPA13 6782
Two-hybrid Homo sapiens
24 UBE2C 11065
Co-fractionation Homo sapiens
25 UBC 7316
Reconstituted Complex Homo sapiens
26 RIC8A 60626
Two-hybrid Homo sapiens
27 HAVCR1  
Two-hybrid Homo sapiens
28 NPHP1  
Two-hybrid Homo sapiens
29 SRSF2 6427
Two-hybrid Homo sapiens
30 PRPF40A 55660
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
31 SUPT20H 55578
Two-hybrid Homo sapiens
32 TRIB2 28951
Two-hybrid Homo sapiens
33 SCG2  
Two-hybrid Homo sapiens
34 KDELR1 10945
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 PTPRN  
Two-hybrid Homo sapiens
36 VPS26A 9559
Co-fractionation Homo sapiens
37 CAPZB 832
Affinity Capture-MS Homo sapiens
38 RNPS1 10921
Two-hybrid Homo sapiens
39 PRDX3 10935
Co-fractionation Homo sapiens
40 ATPIF1 93974
Two-hybrid Homo sapiens
41 OR6T1  
Affinity Capture-MS Homo sapiens
42 CYB5R1 51706
Two-hybrid Homo sapiens
43 GDI1 2664
Two-hybrid Homo sapiens
44 CCDC14  
Two-hybrid Homo sapiens
45 C1orf94  
Two-hybrid Homo sapiens
46 GKAP1  
Two-hybrid Homo sapiens
47 COL8A1 1295
Two-hybrid Homo sapiens
48 PIP4K2B 8396
Two-hybrid Homo sapiens
49 ORC5  
Two-hybrid Homo sapiens
50 DMPK  
Two-hybrid Homo sapiens
51 UBQLN1 29979
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
52 DYNLL1 8655
Affinity Capture-MS Homo sapiens
53 SERPINH1 871
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
54 MLLT6  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
55 CEND1  
Two-hybrid Homo sapiens
56 FZD7 8324
Two-hybrid Homo sapiens
57 UBQLN4 56893
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
58 EEF1A1 1915
Two-hybrid Homo sapiens
59 RAD23A 5886
Two-hybrid Homo sapiens
Co-fractionation Homo sapiens
60 RNF11 26994
Two-hybrid Homo sapiens
61 SERPINI2  
Two-hybrid Homo sapiens
62 MTNR1B  
Two-hybrid Homo sapiens
63 PMEPA1 56937
Two-hybrid Homo sapiens
64 STAM2 10254
Two-hybrid Homo sapiens
65 ZDHHC3 51304
Two-hybrid Homo sapiens
66 RAD23B 5887
Co-fractionation Homo sapiens
67 NAE1 8883
Two-hybrid Homo sapiens
68 NOMO1 23420
Two-hybrid Homo sapiens
69 PTPRN2  
Two-hybrid Homo sapiens
70 Cxx1a  
Affinity Capture-Western Mus musculus
71 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
72 ADPGK 83440
Two-hybrid Homo sapiens
73 PSMD4 5710
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
74 PELI2 57161
Two-hybrid Homo sapiens
75 ATP6V1G2  
Cross-Linking-MS (XL-MS) Homo sapiens
76 CSTF2 1478
Two-hybrid Homo sapiens
77 CCDC33 80125
Two-hybrid Homo sapiens
78 BAG6 7917
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
79 COPB1 1315
Two-hybrid Homo sapiens
80 DAZAP2  
Two-hybrid Homo sapiens
81 CSNK2B 1460
Affinity Capture-MS Homo sapiens
82 RSRC2  
Two-hybrid Homo sapiens
83 MYDGF 56005
Two-hybrid Homo sapiens
84 FGFBP1 9982
Two-hybrid Homo sapiens
85 PSMD2 5708
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
86 UBQLN2 29978
Cross-Linking-MS (XL-MS) Homo sapiens
Two-hybrid Homo sapiens
87 PICK1  
Two-hybrid Homo sapiens
88 SMAD3 4088
Two-hybrid Homo sapiens
89 CCDC107  
Two-hybrid Homo sapiens
90 DTX2 113878
Two-hybrid Homo sapiens
91 ERP29 10961
Two-hybrid Homo sapiens
92 TRIM32 22954
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
93 AGR2 10551
Two-hybrid Homo sapiens
94 NME3 4832
Two-hybrid Homo sapiens
95 UNC119 9094
Two-hybrid Homo sapiens
96 RPN1 6184
Two-hybrid Homo sapiens
97 USMG5 84833
Two-hybrid Homo sapiens
98 CTSB 1508
Two-hybrid Homo sapiens
99 UBXN1 51035
Co-fractionation Homo sapiens
100 DYNLL2 140735
Affinity Capture-MS Homo sapiens
101 UROS 7390
Two-hybrid Homo sapiens
102 MIEF2  
Two-hybrid Homo sapiens
103 ARL4C 10123
Two-hybrid Homo sapiens
104 DNAJB11 51726
Two-hybrid Homo sapiens
105 HERPUD1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
106 STAM 8027
Co-fractionation Homo sapiens
107 RBM10  
Two-hybrid Homo sapiens
108 ZPR1 8882
Co-fractionation Homo sapiens
109 ATXN1 6310
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
110 PTN  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
111 IMMT 10989
Two-hybrid Homo sapiens
112 NUMA1 4926
Affinity Capture-MS Homo sapiens
113 SLC17A2  
Affinity Capture-MS Homo sapiens
114 SPAG8  
Two-hybrid Homo sapiens
115 HSPA5 3309
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
116 EPDR1 54749
Two-hybrid Homo sapiens
117 QSOX1 5768
Two-hybrid Homo sapiens
118 MIF4GD 57409
Two-hybrid Homo sapiens
119 VPS4B 9525
Co-fractionation Homo sapiens
120 GJA5 2702
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
121 CCDC134 79879
Two-hybrid Homo sapiens
122 AHCYL1 10768
Co-fractionation Homo sapiens
123 CSTF2T  
Two-hybrid Homo sapiens
124 TYMS 7298
Co-fractionation Homo sapiens
125 SLC45A4  
Affinity Capture-MS Homo sapiens
126 ZNF205 7755
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
127 CD2BP2 10421
Co-fractionation Homo sapiens
128 EDN1  
Two-hybrid Homo sapiens
129 SCG5  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
130 PPIB 5479
Two-hybrid Homo sapiens
131 C11orf49  
Two-hybrid Homo sapiens
132 CD274 29126
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
133 UBR7  
Two-hybrid Homo sapiens
134 NPPA  
Two-hybrid Homo sapiens
135 ANKRD13D  
Two-hybrid Homo sapiens
136 SERPINE1 5054
Two-hybrid Homo sapiens
137 TGFB1I1 7041
Two-hybrid Homo sapiens
138 LAT2 7462
Two-hybrid Homo sapiens
139 TNRC6B  
Two-hybrid Homo sapiens
140 NXF1 10482
Two-hybrid Homo sapiens
141 GJB1 2705
Affinity Capture-Western Homo sapiens
142 SEMG1 6406
Two-hybrid Homo sapiens
143 RUNX1T1  
Two-hybrid Homo sapiens
144 NOMO3 408050
Two-hybrid Homo sapiens
145 HGS 9146
Two-hybrid Homo sapiens
146 SMAD9  
Two-hybrid Homo sapiens
147 C1QTNF1 114897
Two-hybrid Homo sapiens
148 YWHAQ 10971
Two-hybrid Homo sapiens
149 PLA2G16 11145
Two-hybrid Homo sapiens
150 CACNA1G  
Two-hybrid Homo sapiens
151 CCL21  
Two-hybrid Homo sapiens
152 TTC9C 283237
Co-fractionation Homo sapiens
153 SMARCB1 6598
Two-hybrid Homo sapiens
154 STMN1 3925
Two-hybrid Homo sapiens
155 SCMH1  
Two-hybrid Homo sapiens
156 RNF185  
Affinity Capture-MS Homo sapiens
157 TFF1 7031
Two-hybrid Homo sapiens
158 GABRD  
Two-hybrid Homo sapiens
159 IGLC1 3537
Two-hybrid Homo sapiens
160 TNFRSF14  
Two-hybrid Homo sapiens
161 ZFYVE19 84936
Co-fractionation Homo sapiens
162 CRIPT 9419
Two-hybrid Homo sapiens
163 WAC  
Two-hybrid Homo sapiens
164 PBXIP1 57326
Two-hybrid Homo sapiens
165 PDIA5 10954
Two-hybrid Homo sapiens
166 ACBD5 91452
Proximity Label-MS Homo sapiens
167 ROBO2 6092
Two-hybrid Homo sapiens
168 HK2 3099
Two-hybrid Homo sapiens
169 RAI2  
Two-hybrid Homo sapiens
170 Cbx1  
Affinity Capture-MS Mus musculus
171 GJC1 10052
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
172 PPIC 5480
Two-hybrid Homo sapiens
173 PDLIM7 9260
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
174 SRGN 5552
Two-hybrid Homo sapiens
175 EAPP  
Two-hybrid Homo sapiens
176 TRAF2 7186
Two-hybrid Homo sapiens
177 BCL2A1  
Affinity Capture-Western Homo sapiens
178 IMPDH2 3615
Two-hybrid Homo sapiens
179 ELF5  
Two-hybrid Homo sapiens
180 CPSF6 11052
Two-hybrid Homo sapiens
181 USP34 9736
Co-fractionation Homo sapiens
182 MDK 4192
Two-hybrid Homo sapiens
183 ASNS 440
Co-fractionation Homo sapiens
184 SPP1 6696
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
185 PIN1 5300
Two-hybrid Homo sapiens
186 PRL  
Two-hybrid Homo sapiens
187 ADAM33 80332
Two-hybrid Homo sapiens
188 KLHL26  
Two-hybrid Homo sapiens
189 SPINT1 6692
Two-hybrid Homo sapiens
190 HMGN5 79366
Affinity Capture-MS Homo sapiens
191 SHFM1 7979
Affinity Capture-MS Homo sapiens
192 HDAC1 3065
Affinity Capture-MS Homo sapiens
193 PNMA1 9240
Two-hybrid Homo sapiens
194 VIP  
Two-hybrid Homo sapiens
195 OAT 4942
Two-hybrid Homo sapiens
196 ZFPM2  
Two-hybrid Homo sapiens
197 KLHL42  
Two-hybrid Homo sapiens
198 WWP2 11060
Biochemical Activity Homo sapiens
199 TXN 7295
Co-fractionation Homo sapiens
200 MAP1LC3A 84557
Affinity Capture-Western Homo sapiens
201 UBE2B 7320
Co-fractionation Homo sapiens
202 RXRA 6256
Two-hybrid Homo sapiens
203 ZG16B 124220
Two-hybrid Homo sapiens
204 AREG 374
Two-hybrid Homo sapiens
205 CCDC136  
Two-hybrid Homo sapiens
206 TMEM31  
Affinity Capture-MS Homo sapiens
207 IGFBP6 3489
Two-hybrid Homo sapiens
208 GPX7 2882
Two-hybrid Homo sapiens
209 PCDH17  
Two-hybrid Homo sapiens
210 MOAP1  
Two-hybrid Homo sapiens
211 ERP27  
Two-hybrid Homo sapiens
212 FKBP2 2286
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
213 BCL2L10  
Affinity Capture-Western Homo sapiens
214 EFEMP2 30008
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which UBQLN4 is involved
No pathways found





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