Gene description for LACRT
Gene name lacritin
Gene symbol LACRT
Other names/aliases -
Species Homo sapiens
 Database cross references - LACRT
ExoCarta ExoCarta_90070
Entrez Gene 90070
HGNC 16430
MIM 607360
UniProt Q9GZZ8  
 LACRT identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for LACRT
Molecular Function
    collagen binding GO:0005518 IDA
    laminin-1 binding GO:0043237 IDA
    glycoprotein binding GO:0001948 IDA
    fibronectin binding GO:0001968 IDA
    protein N-terminus binding GO:0047485 IPI
    growth factor activity GO:0008083 IDA
Biological Process
    calcineurin-NFAT signaling cascade GO:0033173 IDA
    positive regulation of release of sequestered calcium ion into cytosol GO:0051281 IDA
    protein localization to Golgi apparatus GO:0034067 IDA
    positive regulation of NFAT protein import into nucleus GO:0051533 IDA
    calcium-mediated signaling GO:0019722 IDA
    tear secretion GO:0070075 NAS
    positive regulation of epithelial cell proliferation GO:0050679 IDA
    positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IDA
    positive regulation of secretion GO:0051047 IDA
    positive regulation of cell proliferation GO:0008284 IDA
Subcellular Localization
    extracellular space GO:0005615 IDA
    secretory granule GO:0030141 IDA
    extracellular region GO:0005576 IDA
 Experiment description of studies that identified LACRT in exosomes
Experiment ID 126
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for LACRT
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 VTN 7448
Reconstituted Complex Homo sapiens
2 FN1 2335
Reconstituted Complex Homo sapiens
3 SDC1 6382
Co-purification Homo sapiens
4 NID1 4811
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which LACRT is involved
No pathways found

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