Gene description for CHD8
Gene name	chromodomain helicase DNA binding protein 8
Gene symbol	CHD8
Other names/aliases	AUTS18 HELSNF1
Species	Homo sapiens
Database cross references - CHD8
ExoCarta	ExoCarta_57680
Vesiclepedia	VP_57680
Entrez Gene	57680
HGNC	20153
MIM	610528
UniProt	Q9HCK8
CHD8 identified in exosomes derived from the following tissue/cell type
Hepatocytes	26054723

Gene ontology annotations for CHD8

Molecular Function     p53 binding GO:0002039 ISS     DNA binding GO:0003677 IBA     DNA binding GO:0003677 IMP     chromatin binding GO:0003682 IBA     chromatin binding GO:0003682 IDA     DNA clamp loader activity GO:0003689 IEA     protein binding GO:0005515 IPI     ATP binding GO:0005524 IDA     beta-catenin binding GO:0008013 IDA     four-way junction helicase activity GO:0009378 IEA     ATP hydrolysis activity GO:0016887 IBA     methylated histone binding GO:0035064 IDA     double-stranded DNA helicase activity GO:0036121 IEA     histone binding GO:0042393 IBA     histone binding GO:0042393 ISS     forked DNA-dependent helicase activity GO:0061749 IEA     cohesin loader activity GO:0061775 IEA     chromatin extrusion motor activity GO:0140584 IEA     ATP-dependent chromatin remodeler activity GO:0140658 IBA     ATP-dependent chromatin remodeler activity GO:0140658 IDA     ATP-dependent H3-H4 histone complex chaperone activity GO:0140665 IEA     ATP-dependent H2AZ histone chaperone activity GO:0140849 IEA     single-stranded 3'-5' DNA helicase activity GO:1990518 IEA Biological Process     negative regulation of transcription by RNA polymerase II GO:0000122 IMP     in utero embryonic development GO:0001701 IEA     chromatin remodeling GO:0006338 IBA     chromatin remodeling GO:0006338 IMP     mRNA processing GO:0006397 IMP     brain development GO:0007420 IBA     brain development GO:0007420 IMP     Wnt signaling pathway GO:0016055 IEA     DNA duplex unwinding GO:0032508 IEA     social behavior GO:0035176 IEA     negative regulation of DNA-templated transcription GO:0045892 IBA     negative regulation of DNA-templated transcription GO:0045892 IMP     positive regulation of DNA-templated transcription GO:0045893 IDA     positive regulation of transcription by RNA polymerase II GO:0045944 IMP     positive regulation of transcription by RNA polymerase III GO:0045945 IMP     digestive tract development GO:0048565 IBA     digestive tract development GO:0048565 IMP     prepulse inhibition GO:0060134 IEA     negative regulation of canonical Wnt signaling pathway GO:0090090 IBA     negative regulation of canonical Wnt signaling pathway GO:0090090 IDA     negative regulation of canonical Wnt signaling pathway GO:0090090 IDA     chromatin looping GO:0140588 IEA     negative regulation of fibroblast apoptotic process GO:2000270 IEA Subcellular Localization     chromatin GO:0000785 IBA     nucleus GO:0005634 IBA     nucleus GO:0005634 IDA     nucleoplasm GO:0005654 IDA     nucleoplasm GO:0005654 TAS     protein-containing complex GO:0032991 IDA     MLL1 complex GO:0071339 IBA     MLL1 complex GO:0071339 IDA