Gene description for SLC9A3R2
Gene name solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
Gene symbol SLC9A3R2
Other names/aliases E3KARP
NHE3RF2
NHERF-2
NHERF2
OCTS2
SIP-1
SIP1
TKA-1
Species Homo sapiens
 Database cross references - SLC9A3R2
ExoCarta ExoCarta_9351
Entrez Gene 9351
HGNC 11076
MIM 606553
UniProt Q15599  
 SLC9A3R2 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Urine 19056867    
 Gene ontology annotations for SLC9A3R2
Molecular Function
    protein binding GO:0005515 IPI
    phosphatase binding GO:0019902 IPI
    protein C-terminus binding GO:0008022 IPI
    beta-catenin binding GO:0008013 IPI
    receptor binding GO:0005102 IPI
Biological Process
    negative regulation of phosphatidylinositol 3-kinase signaling GO:0014067 IEA
    protein complex assembly GO:0006461 TAS
Subcellular Localization
    nucleus GO:0005634 IEA
    endomembrane system GO:0012505 IEA
    focal adhesion GO:0005925 IDA
    apical plasma membrane GO:0016324 IEA
    extracellular exosome GO:0070062 IDA
    cytoplasm GO:0005737 IEA
    plasma membrane GO:0005886 IDA
 Experiment description of studies that identified SLC9A3R2 in exosomes
1
Experiment ID 211
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
cytochrome c|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
Cytochrome C|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for SLC9A3R2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ACTN4 81
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
2 PIK3CA 5290
Reconstituted Complex Homo sapiens
3 EZR 7430
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
4 ADRB2  
Invitro Homo sapiens
5 PTHR1  
Invivo Homo sapiens
6 KCNJ1  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
7 CFTR  
Invivo Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
8 PDZK1 5174
Two-hybrid Homo sapiens
9 PODXL 5420
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
10 SGK1  
Invivo Homo sapiens
Invitro Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
11 WWTR1 25937
Affinity Capture-Western Homo sapiens
12 ADORA2B  
Affinity Capture-Western Homo sapiens
13 Rdx 19684
Co-crystal Structure Mus musculus
14 SLC9A3 6550
Reconstituted Complex Homo sapiens
15 P2RY1  
Invitro Homo sapiens
16 PDPK1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
17 SGKL  
Invitro Homo sapiens
18 PLCB3 5331
Invivo Homo sapiens
19 SLC26A3  
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which SLC9A3R2 is involved
No pathways found





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