Gene description for UCHL5
Gene name ubiquitin carboxyl-terminal hydrolase L5
Gene symbol UCHL5
Other names/aliases CGI-70
INO80R
UCH-L5
UCH37
Species Homo sapiens
 Database cross references - UCHL5
ExoCarta ExoCarta_51377
Vesiclepedia VP_51377
Entrez Gene 51377
HGNC 19678
MIM 610667
UniProt Q9Y5K5  
 UCHL5 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Thymus 23844026    
 Gene ontology annotations for UCHL5
Molecular Function
    RNA binding GO:0003723 HDA
    cysteine-type deubiquitinase activity GO:0004843 IBA
    cysteine-type deubiquitinase activity GO:0004843 IDA
    cysteine-type deubiquitinase activity GO:0004843 IMP
    endopeptidase inhibitor activity GO:0004866 IMP
    protein binding GO:0005515 IPI
    proteasome binding GO:0070628 IDA
Biological Process
    telomere maintenance GO:0000723 ISO
    regulation of DNA replication GO:0006275 IMP
    DNA repair GO:0006281 IEA
    regulation of DNA repair GO:0006282 ISO
    DNA recombination GO:0006310 IEA
    chromatin remodeling GO:0006338 IDA
    ubiquitin-dependent protein catabolic process GO:0006511 IEA
    protein deubiquitination GO:0016579 IDA
    lateral ventricle development GO:0021670 IEA
    midbrain development GO:0030901 IEA
    negative regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032435 IMP
    regulation of chromosome organization GO:0033044 IBA
    regulation of chromosome organization GO:0033044 IMP
    positive regulation of DNA repair GO:0045739 ISO
    positive regulation of smoothened signaling pathway GO:0045880 IMP
    positive regulation of DNA-templated transcription GO:0045893 IMP
    regulation of embryonic development GO:0045995 ISO
    forebrain morphogenesis GO:0048853 IEA
    regulation of cell cycle GO:0051726 IMP
    regulation of DNA strand elongation GO:0060382 IMP
    regulation of proteasomal protein catabolic process GO:0061136 IMP
    positive regulation of telomere maintenance in response to DNA damage GO:1904507 ISO
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    nucleolus GO:0005730 IDA
    cytoplasm GO:0005737 IBA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    Ino80 complex GO:0031011 IDA
    cytosolic proteasome complex GO:0031597 IEA
 Experiment description of studies that identified UCHL5 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
7
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
8
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
9
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
10
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for UCHL5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PSMA6 5687
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 MCRS1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 PSME2 5721
Affinity Capture-MS Homo sapiens
4 HIST1H4K 8362
Reconstituted Complex Homo sapiens
5 KRT73 319101
Reconstituted Complex Homo sapiens
6 ISG15 9636
Affinity Capture-MS Homo sapiens
7 INO80B 83444
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 KRT6B 3854
Affinity Capture-MS Homo sapiens
9 KRT1 3848
Affinity Capture-MS Homo sapiens
10 EEF1G 1937
Reconstituted Complex Homo sapiens
11 Ruvbl1 56505
Affinity Capture-MS Mus musculus
12 PSMD6 9861
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 ZFAND2B  
Affinity Capture-MS Homo sapiens
14 RNF4 6047
Biochemical Activity Homo sapiens
15 PKM 5315
Reconstituted Complex Homo sapiens
16 PSMA4 5685
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
17 PSMD11 5717
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 USP5 8078
Affinity Capture-MS Homo sapiens
19 NACA 4666
Reconstituted Complex Homo sapiens
20 E2F1 1869
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
21 ACTC1 70
Affinity Capture-MS Homo sapiens
22 ANXA8 653145
Reconstituted Complex Homo sapiens
23 MAP4 4134
Co-fractionation Homo sapiens
24 UBE3A 7337
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 UBC 7316
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
26 CSTA 1475
Reconstituted Complex Homo sapiens
27 CALM1 801
Reconstituted Complex Homo sapiens
28 TRIM55  
Biochemical Activity Homo sapiens
29 HBB 3043
Reconstituted Complex Homo sapiens
30 PSMD10 5716
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 FHOD1 29109
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 CFL1 1072
Reconstituted Complex Homo sapiens
33 CCDC92  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 ELF4 2000
Proximity Label-MS Homo sapiens
35 ARNTL  
Affinity Capture-MS Homo sapiens
36 ANP32B 10541
Reconstituted Complex Homo sapiens
37 TRIM54  
Biochemical Activity Homo sapiens
38 KDELR1 10945
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 S100A14 57402
Reconstituted Complex Homo sapiens
40 HIST1H4F 8361
Reconstituted Complex Homo sapiens
41 POTEE 445582
Affinity Capture-MS Homo sapiens
42 CAPZB 832
Affinity Capture-MS Homo sapiens
43 CCDC74A  
Affinity Capture-MS Homo sapiens
44 E2F2 1870
Reconstituted Complex Homo sapiens
45 RUVBL1 8607
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 PJA1  
Biochemical Activity Homo sapiens
47 YWHAZ 7534
Reconstituted Complex Homo sapiens
48 PRDX3 10935
Affinity Capture-MS Homo sapiens
49 CYB5B 80777
Affinity Capture-MS Homo sapiens
50 CIAPIN1 57019
Co-fractionation Homo sapiens
51 GNS 2799
Co-fractionation Homo sapiens
52 KIF5B 3799
Co-fractionation Homo sapiens
53 Htatsf1  
Two-hybrid Mus musculus
54 OSBP 5007
Co-fractionation Homo sapiens
55 DUSP14 11072
Reconstituted Complex Homo sapiens
56 UBQLN1 29979
Affinity Capture-MS Homo sapiens
57 VCP 7415
Affinity Capture-MS Homo sapiens
58 PSMD12 5718
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 PSMB6 5694
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
60 PSMC6 5706
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 ARMT1 79624
Co-fractionation Homo sapiens
62 ELK3  
Proximity Label-MS Homo sapiens
63 PSMC2 5701
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 PLCG1 5335
Co-fractionation Homo sapiens
65 HIST4H4 121504
Reconstituted Complex Homo sapiens
66 KRT78 196374
Reconstituted Complex Homo sapiens
67 FLG 2312
Reconstituted Complex Homo sapiens
68 HERC2 8924
Affinity Capture-MS Homo sapiens
69 PPP1R2P4  
Co-fractionation Homo sapiens
70 PSMG1 8624
Affinity Capture-MS Homo sapiens
71 UCHL5 51377
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
72 PSMB9 5698
Affinity Capture-MS Homo sapiens
73 HIST1H4I 8294
Reconstituted Complex Homo sapiens
74 PAAF1 80227
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 PSMD5 5711
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
76 CCNDBP1 23582
Affinity Capture-MS Homo sapiens
77 CSNK2B 1460
Affinity Capture-MS Homo sapiens
78 SERPINB5 5268
Reconstituted Complex Homo sapiens
79 COMMD4 54939
Co-fractionation Homo sapiens
80 PSMC3 5702
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
81 RAD23A 5886
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
82 POTEKP 440915
Affinity Capture-MS Homo sapiens
83 DSC3 1825
Reconstituted Complex Homo sapiens
84 PSME3 10197
Affinity Capture-MS Homo sapiens
85 RBMX 27316
Co-fractionation Homo sapiens
86 UNC45A 55898
Co-fractionation Homo sapiens
87 PFN1 5216
Affinity Capture-MS Homo sapiens
88 CHMP4C 92421
Affinity Capture-MS Homo sapiens
89 INO80E  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
90 KRT12 3859
Reconstituted Complex Homo sapiens
91 ANXA7 310
Reconstituted Complex Homo sapiens
92 RAD23B 5887
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
93 POF1B 79983
Reconstituted Complex Homo sapiens
94 IDE 3416
Reconstituted Complex Homo sapiens
95 USP12 219333
Affinity Capture-MS Homo sapiens
96 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
97 NFRKB  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Co-crystal Structure Homo sapiens
Co-purification Homo sapiens
Co-crystal Structure Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
98 CAPZA1 829
Reconstituted Complex Homo sapiens
99 USP14 9097
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
100 PSMD4 5710
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
101 HIST1H4E 8367
Reconstituted Complex Homo sapiens
102 WDR61 80349
Co-fractionation Homo sapiens
103 PSMC1 5700
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
104 PSMD14 10213
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
105 IGHG1 3500
Reconstituted Complex Homo sapiens
106 PPIH 10465
Co-fractionation Homo sapiens
107 ARG1 383
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
108 S100A16 140576
Reconstituted Complex Homo sapiens
109 CYB5A 1528
Affinity Capture-MS Homo sapiens
110 PSMD2 5708
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
111 TRIM16 10626
Co-fractionation Homo sapiens
112 ACTN4 81
Reconstituted Complex Homo sapiens
113 NTRK1 4914
Affinity Capture-MS Homo sapiens
114 ACTL6A 86
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
115 SMAD3 4088
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
116 U2AF2 11338
Co-fractionation Homo sapiens
117 EEF2 1938
Reconstituted Complex Homo sapiens
118 HIST2H4A 8370
Reconstituted Complex Homo sapiens
119 ECHS1 1892
Affinity Capture-MS Homo sapiens
120 NOS2  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
121 SMAD2 4087
Reconstituted Complex Homo sapiens
122 CAP1 10487
Reconstituted Complex Homo sapiens
123 ACTB 60
Affinity Capture-MS Homo sapiens
124 PSMA7 5688
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
125 PNP 4860
Reconstituted Complex Homo sapiens
126 TGM3 7053
Reconstituted Complex Homo sapiens
127 PSME1 5720
Affinity Capture-MS Homo sapiens
128 KRT80 144501
Reconstituted Complex Homo sapiens
129 CCDC74B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
130 HAUS7  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
131 ACTG1 71
Affinity Capture-MS Homo sapiens
132 USP28 57646
Biochemical Activity Homo sapiens
133 HBA1 3039
Reconstituted Complex Homo sapiens
134 TRIM63  
Biochemical Activity Homo sapiens
135 KRT9 3857
Affinity Capture-MS Homo sapiens
136 ZBED1  
Two-hybrid Homo sapiens
137 OGT 8473
Biochemical Activity Homo sapiens
138 HIST1H4C 8364
Reconstituted Complex Homo sapiens
139 TXN2 25828
Reconstituted Complex Homo sapiens
140 SERPINB12 89777
Reconstituted Complex Homo sapiens
141 SLC17A2  
Affinity Capture-MS Homo sapiens
142 CASP14 23581
Reconstituted Complex Homo sapiens
143 HSPA5 3309
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
144 ANXA1 301
Reconstituted Complex Homo sapiens
145 PSMA3 5684
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
146 SERPINB3 6317
Reconstituted Complex Homo sapiens
147 CCNA2 890
Co-fractionation Homo sapiens
148 IVL 3713
Reconstituted Complex Homo sapiens
149 FTL 2512
Affinity Capture-MS Homo sapiens
150 HIST1H4D 8360
Reconstituted Complex Homo sapiens
151 RAB7A 7879
Reconstituted Complex Homo sapiens
152 TIPRL 261726
Co-fractionation Homo sapiens
153 S100A7 6278
Reconstituted Complex Homo sapiens
154 USP15 9958
Affinity Capture-MS Homo sapiens
155 SRXN1 140809
Affinity Capture-MS Homo sapiens
156 PSMD13 5719
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
157 ANXA8L1 728113
Reconstituted Complex Homo sapiens
158 TPI1 7167
Reconstituted Complex Homo sapiens
159 PLRG1 5356
Co-fractionation Homo sapiens
160 CTNNB1 1499
Affinity Capture-Western Homo sapiens
161 PSMG2 56984
Affinity Capture-MS Homo sapiens
162 KCMF1 56888
Co-fractionation Homo sapiens
163 PRDX2 7001
Affinity Capture-MS Homo sapiens
164 ANXA4 307
Reconstituted Complex Homo sapiens
165 EPPK1 83481
Reconstituted Complex Homo sapiens
166 C7orf76  
Affinity Capture-MS Homo sapiens
167 HIST2H4B 554313
Reconstituted Complex Homo sapiens
168 PSMA2 5683
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
169 PSMB8 5696
Co-fractionation Homo sapiens
170 YY1 7528
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
171 TFPT  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
172 EIF4A1 1973
Reconstituted Complex Homo sapiens
173 FTH1 2495
Affinity Capture-MS Homo sapiens
174 ANP32E 81611
Reconstituted Complex Homo sapiens
175 RIPK4  
Affinity Capture-MS Homo sapiens
176 KRT26 353288
Reconstituted Complex Homo sapiens
177 FDFT1 2222
Affinity Capture-MS Homo sapiens
178 MAP3K1 4214
Biochemical Activity Homo sapiens
179 TUBA4A 7277
Reconstituted Complex Homo sapiens
180 HIST1H4B 8366
Reconstituted Complex Homo sapiens
181 MAPK6  
Affinity Capture-MS Homo sapiens
182 ACTR5 79913
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
183 UBLCP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
184 BAG1 573
Affinity Capture-MS Homo sapiens
185 RGPD5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
186 SET 6418
Reconstituted Complex Homo sapiens
187 INO80  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
188 TXNL1 9352
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
189 ACTR8 93973
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
190 PSMC5 5705
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
191 DDI2 84301
Affinity Capture-MS Homo sapiens
192 PSMB5 5693
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
193 PLA2G2A 5320
Biochemical Activity Homo sapiens
194 KIAA0368 23392
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
195 RBP1 5947
Affinity Capture-MS Homo sapiens
196 KRT19 3880
Reconstituted Complex Homo sapiens
197 LMNA 4000
Reconstituted Complex Homo sapiens
198 Psmd6 66413
Affinity Capture-MS Mus musculus
199 PSMD7 5713
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
200 PSMB1 5689
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
201 APP 351
Reconstituted Complex Homo sapiens
202 HUWE1 10075
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
203 AR 367
Proximity Label-MS Homo sapiens
204 DSP 1832
Reconstituted Complex Homo sapiens
205 PSMB3 5691
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
206 ZRANB1 54764
Affinity Capture-MS Homo sapiens
207 TRIM46 80128
Two-hybrid Homo sapiens
208 PSMB2 5690
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
209 Adrm1  
Affinity Capture-Western Mus musculus
210 Ruvbl2 20174
Affinity Capture-MS Mus musculus
211 RFFL 117584
Biochemical Activity Homo sapiens
212 PSMD1 5707
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
213 SMAD7  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
214 FBXL6  
Affinity Capture-MS Homo sapiens
215 POTEF 728378
Affinity Capture-MS Homo sapiens
216 RPS21 6227
Co-fractionation Homo sapiens
217 RGPD8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
218 RUVBL2 10856
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
219 HIST1H4H 8365
Reconstituted Complex Homo sapiens
220 PSMC4 5704
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
221 PSMB7 5695
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
222 TRIM27  
Two-hybrid Homo sapiens
223 LOC145837  
Affinity Capture-RNA Homo sapiens
224 HBA2 3040
Reconstituted Complex Homo sapiens
225 CTSD 1509
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
226 CDSN 1041
Reconstituted Complex Homo sapiens
227 SQSTM1 8878
Affinity Capture-Western Homo sapiens
228 DSC1 1823
Reconstituted Complex Homo sapiens
229 SHFM1 7979
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
230 HSPB1 3315
Reconstituted Complex Homo sapiens
231 KRT28 162605
Reconstituted Complex Homo sapiens
232 PTPN2 5771
Affinity Capture-MS Homo sapiens
233 RNF20 56254
Co-fractionation Homo sapiens
234 GTF2I 2969
Affinity Capture-MS Homo sapiens
235 AXIN1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
236 PKP1 5317
Reconstituted Complex Homo sapiens
237 ASPRV1  
Reconstituted Complex Homo sapiens
238 PSMA1 5682
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
239 UBE3C 9690
Affinity Capture-MS Homo sapiens
240 INO80C  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
241 GSTM3 2947
Reconstituted Complex Homo sapiens
242 E2F3  
Reconstituted Complex Homo sapiens
243 TXN 7295
Reconstituted Complex Homo sapiens
244 XPO5 57510
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
245 KDM1A 23028
Two-hybrid Homo sapiens
246 HIST1H4L 8368
Reconstituted Complex Homo sapiens
247 PSMA5 5686
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
248 APOB 338
Affinity Capture-MS Homo sapiens
249 C16orf72 29035
Affinity Capture-MS Homo sapiens
250 PRDX6 9588
Reconstituted Complex Homo sapiens
251 INO80D  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
252 HIST1H4J 8363
Reconstituted Complex Homo sapiens
253 PRDX1 5052
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
254 PSMF1 9491
Affinity Capture-MS Homo sapiens
255 KRT10 3858
Affinity Capture-MS Homo sapiens
256 SERBP1 26135
Affinity Capture-MS Homo sapiens
257 SNW1 22938
Affinity Capture-MS Homo sapiens
258 ADRM1 11047
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Affinity Capture-MS Homo sapiens
Co-crystal Structure Homo sapiens
Co-purification Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
259 C9orf72  
Affinity Capture-MS Homo sapiens
260 TMEM31  
Affinity Capture-MS Homo sapiens
261 PSMB4 5692
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
262 APOA1 335
Affinity Capture-MS Homo sapiens
263 SNRPA1 6627
Co-fractionation Homo sapiens
264 RBCK1  
Two-hybrid Homo sapiens
265 PSMD8 5714
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
266 XPNPEP1 7511
Co-fractionation Homo sapiens
267 CDC5L 988
Affinity Capture-MS Homo sapiens
268 PSMD3 5709
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
269 PSME4 23198
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
270 PNN 5411
Cross-Linking-MS (XL-MS) Homo sapiens
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Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here