Gene description for FURIN
Gene name	furin (paired basic amino acid cleaving enzyme)
Gene symbol	FURIN
Other names/aliases	FUR PACE PCSK3 SPC1
Species	Homo sapiens
Database cross references - FURIN
ExoCarta	ExoCarta_5045
Vesiclepedia	VP_5045
Entrez Gene	5045
HGNC	8568
MIM	136950
UniProt	P09958
FURIN identified in sEVs derived from the following tissue/cell type
Saliva	19199708

Gene ontology annotations for FURIN

Molecular Function     protease binding GO:0002020 IPI     endopeptidase activity GO:0004175 IDA     endopeptidase activity GO:0004175 IMP     endopeptidase activity GO:0004175 TAS     serine-type endopeptidase activity GO:0004252 IBA     serine-type endopeptidase activity GO:0004252 IDA     serine-type endopeptidase activity GO:0004252 IMP     serine-type endopeptidase activity GO:0004252 TAS     serine-type endopeptidase inhibitor activity GO:0004867 IDA     protein binding GO:0005515 IPI     heparin binding GO:0008201 IDA     peptidase activity GO:0008233 IDA     serine-type peptidase activity GO:0008236 IDA     peptide binding GO:0042277 IDA     metal ion binding GO:0046872 IEA     nerve growth factor binding GO:0048406 IDA     heparan sulfate binding GO:1904399 IDA Biological Process     blastocyst formation GO:0001825 IEA     negative regulation of inflammatory response to antigenic stimulus GO:0002862 TAS     signal peptide processing GO:0006465 IDA     signal peptide processing GO:0006465 TAS     transforming growth factor beta receptor signaling pathway GO:0007179 TAS     regulation of signal transduction GO:0009966 IEA     protein processing GO:0016485 IDA     protein processing GO:0016485 IDA     protein processing GO:0016485 IMP     peptide hormone processing GO:0016486 IBA     peptide hormone processing GO:0016486 IDA     viral life cycle GO:0019058 IEP     viral translation GO:0019081 TAS     viral protein processing GO:0019082 TAS     extracellular matrix disassembly GO:0022617 TAS     extracellular matrix organization GO:0030198 TAS     collagen catabolic process GO:0030574 TAS     zymogen activation GO:0031638 IMP     regulation of cholesterol transport GO:0032374 IEA     negative regulation of low-density lipoprotein particle receptor catabolic process GO:0032804 IDA     nerve growth factor production GO:0032902 IDA     negative regulation of nerve growth factor production GO:0032904 IDA     negative regulation of transforming growth factor beta1 production GO:0032911 IMP     secretion by cell GO:0032940 IDA     plasma lipoprotein particle remodeling GO:0034369 TAS     regulation of protein catabolic process GO:0042176 IMP     peptide biosynthetic process GO:0043043 IDA     positive regulation of viral entry into host cell GO:0046598 IDA     positive regulation of membrane protein ectodomain proteolysis GO:0051044 IC     protein maturation GO:0051604 IDA     regulation of endopeptidase activity GO:0052548 IDA     dibasic protein processing GO:0090472 IMP     zymogen inhibition GO:0097341 IMP     cytokine precursor processing GO:0140447 IDA     amyloid fibril formation GO:1990000 TAS Subcellular Localization     Golgi membrane GO:0000139 IBA     Golgi membrane GO:0000139 IMP     Golgi membrane GO:0000139 TAS     extracellular region GO:0005576 TAS     extracellular space GO:0005615 IDA     endoplasmic reticulum GO:0005783 IGI     Golgi lumen GO:0005796 TAS     trans-Golgi network GO:0005802 IBA     trans-Golgi network GO:0005802 IDA     plasma membrane GO:0005886 TAS     cell surface GO:0009986 IDA     endosome membrane GO:0010008 IEA     membrane GO:0016020 HDA     trans-Golgi network transport vesicle GO:0030140 IDA     membrane raft GO:0045121 IDA     extracellular exosome GO:0070062 HDA