Gene description for FURIN
Gene name furin (paired basic amino acid cleaving enzyme)
Gene symbol FURIN
Other names/aliases FUR
Species Homo sapiens
 Database cross references - FURIN
ExoCarta ExoCarta_5045
Entrez Gene 5045
HGNC 8568
MIM 136950
UniProt P09958  
 FURIN identified in exosomes derived from the following tissue/cell type
Saliva 19199708    
 Gene ontology annotations for FURIN
Molecular Function
    peptide binding GO:0042277 IDA
    peptidase activity GO:0008233 IDA
    protein binding GO:0005515 IPI
    serine-type endopeptidase inhibitor activity GO:0004867 IDA
    protease binding GO:0002020 IPI
    serine-type endopeptidase activity GO:0004252 IDA
    nerve growth factor binding GO:0048406 IDA
    endopeptidase activity GO:0004175 IDA
    metal ion binding GO:0046872 IEA
Biological Process
    peptide hormone processing GO:0016486 IDA
    post-translational protein modification GO:0043687 TAS
    secretion by cell GO:0032940 IDA
    negative regulation of low-density lipoprotein particle receptor catabolic process GO:0032804 IDA
    protein processing GO:0016485 IMP
    signal peptide processing GO:0006465 IDA
    extracellular matrix disassembly GO:0022617 TAS
    negative regulation of endopeptidase activity GO:0010951 IDA
    nerve growth factor production GO:0032902 IDA
    regulation of signal transduction GO:0009966 IEA
    cell proliferation GO:0008283 IMP
    collagen catabolic process GO:0030574 TAS
    peptidyl-glutamic acid carboxylation GO:0017187 TAS
    viral process GO:0016032 TAS
    nerve growth factor processing GO:0032455 TAS
    negative regulation of transforming growth factor beta1 production GO:0032911 IMP
    regulation of endopeptidase activity GO:0052548 IDA
    viral protein processing GO:0019082 TAS
    Notch signaling pathway GO:0007219 TAS
    peptide biosynthetic process GO:0043043 IDA
    proteolysis GO:0006508 TAS
    transforming growth factor beta receptor signaling pathway GO:0007179 TAS
    regulation of protein catabolic process GO:0042176 IMP
    negative regulation of nerve growth factor production GO:0032904 IDA
    cellular protein metabolic process GO:0044267 TAS
    neurotrophin TRK receptor signaling pathway GO:0048011 TAS
    extracellular matrix organization GO:0030198 TAS
    positive regulation of membrane protein ectodomain proteolysis GO:0051044 IC
    virion assembly GO:0019068 TAS
    viral life cycle GO:0019058 IEP
Subcellular Localization
    Golgi lumen GO:0005796 TAS
    trans-Golgi network GO:0005802 IDA
    integral component of membrane GO:0016021 IEA
    plasma membrane GO:0005886 TAS
    trans-Golgi network transport vesicle GO:0030140 IDA
    membrane GO:0016020 IDA
    extracellular space GO:0005615 IDA
    extracellular exosome GO:0070062 IDA
    membrane raft GO:0045121 IDA
    Golgi membrane GO:0000139 TAS
    cell surface GO:0009986 IDA
 Experiment description of studies that identified FURIN in exosomes
Experiment ID 66
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for FURIN
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PACS1  
Invivo Homo sapiens
Invitro Homo sapiens
2 Flna 192176
Affinity Capture-Western Mus musculus
Two-hybrid Mus musculus
Reconstituted Complex Mus musculus
Reconstituted Complex Homo sapiens
4 AP2M1 1173
Invitro Homo sapiens
5 LRP1 4035
Invivo Homo sapiens
Invitro Homo sapiens
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