Gene description for AES
Gene name	amino-terminal enhancer of split
Gene symbol	AES
Other names/aliases	AES-1 AES-2 ESP1 GRG GRG5 Grg-5 TLE5
Species	Homo sapiens
Database cross references - AES
ExoCarta	ExoCarta_166
Entrez Gene	166
HGNC	307
MIM	600188
UniProt	Q08117
AES identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells	26054723
Hepatocellular carcinoma cells	26054723
Hepatocytes	26054723

Gene ontology annotations for AES

Molecular Function     transcription corepressor activity GO:0003714 IPI     protein binding GO:0005515 IPI Biological Process     multicellular organismal development GO:0007275 TAS     positive regulation of anoikis GO:2000210 IMP     skeletal system development GO:0001501 IEA     negative regulation of response to cytokine stimulus GO:0060761 IMP     negative regulation of gene expression GO:0010629 IMP     Wnt signaling pathway GO:0016055 IEA     organ morphogenesis GO:0009887 TAS     negative regulation of canonical Wnt signaling pathway GO:0090090 IDA     cellular response to extracellular stimulus GO:0031668 IEA     transcription, DNA-templated GO:0006351 IEA     regulation of growth GO:0040008 IEA     response to interleukin-1 GO:0070555 IDA     negative regulation of transcription from RNA polymerase II promoter GO:0000122 IMP     negative regulation of transcription, DNA-templated GO:0045892 IDA     negative regulation of protein binding GO:0032091 IDA Subcellular Localization     nucleus GO:0005634 IDA