Gene description for BMP7
Gene name	bone morphogenetic protein 7
Gene symbol	BMP7
Other names/aliases	OP-1
Species	Homo sapiens
Database cross references - BMP7
ExoCarta	ExoCarta_655
Vesiclepedia	VP_655
Entrez Gene	655
HGNC	1074
MIM	112267
UniProt	P18075
BMP7 identified in exosomes derived from the following tissue/cell type
Prostate cancer cells	25844599
Prostate cancer cells	25844599

Gene ontology annotations for BMP7

Molecular Function     cytokine activity GO:0005125 IBA     protein binding GO:0005515 IPI     growth factor activity GO:0008083 IDA     heparin binding GO:0008201 IEA     protein serine/threonine kinase activator activity GO:0043539 IDA     BMP receptor binding GO:0070700 IPI Biological Process     skeletal system development GO:0001501 TAS     osteoblast differentiation GO:0001649 IDA     metanephros development GO:0001656 IEP     ureteric bud development GO:0001657 ISS     mesoderm formation GO:0001707 IEA     mesonephros development GO:0001823 IEP     epithelial to mesenchymal transition GO:0001837 TAS     endocardial cushion formation GO:0003272 ISS     pericardium morphogenesis GO:0003344 ISS     axon guidance GO:0007411 IEA     embryonic pattern specification GO:0009880 IEA     positive regulation of gene expression GO:0010628 IDA     negative regulation of striated muscle cell apoptotic process GO:0010664 ISS     positive regulation of epithelial to mesenchymal transition GO:0010718 IEA     dendrite development GO:0016358 TAS     neural fold elevation formation GO:0021502 ISS     embryonic limb morphogenesis GO:0030326 IEA     positive regulation of bone mineralization GO:0030501 IDA     BMP signaling pathway GO:0030509 IBA     BMP signaling pathway GO:0030509 IDA     BMP signaling pathway GO:0030509 IMP     BMP signaling pathway GO:0030509 TAS     positive regulation of epithelial cell differentiation GO:0030858 IEA     hindbrain development GO:0030902 ISS     negative regulation of NF-kappaB transcription factor activity GO:0032088 ISS     response to estradiol GO:0032355 IEA     response to vitamin D GO:0033280 IEA     positive regulation of heterotypic cell-cell adhesion GO:0034116 IDA     ameloblast differentiation GO:0036305 IEA     odontogenesis of dentin-containing tooth GO:0042475 IEA     positive regulation of apoptotic process GO:0043065 IEA     response to peptide hormone GO:0043434 IEA     negative regulation of neuron differentiation GO:0045665 IDA     positive regulation of neuron differentiation GO:0045666 IEA     positive regulation of osteoblast differentiation GO:0045669 IDA     negative regulation of Notch signaling pathway GO:0045746 IEA     negative regulation of cell cycle GO:0045786 IDA     negative regulation of mitotic nuclear division GO:0045839 IDA     negative regulation of DNA-templated transcription GO:0045892 IDA     positive regulation of DNA-templated transcription GO:0045893 IDA     positive regulation of DNA-templated transcription GO:0045893 IMP     positive regulation of transcription by RNA polymerase II GO:0045944 IEA     embryonic camera-type eye morphogenesis GO:0048596 IEA     cardiac muscle tissue development GO:0048738 ISS     branching morphogenesis of an epithelial tube GO:0048754 IEA     mesenchymal cell differentiation GO:0048762 IDA     neuron projection morphogenesis GO:0048812 IDA     negative regulation of neurogenesis GO:0050768 IEA     cartilage development GO:0051216 IEA     pharyngeal system development GO:0060037 ISS     embryonic skeletal joint morphogenesis GO:0060272 IEA     positive regulation of SMAD protein signal transduction GO:0060391 IDA     positive regulation of SMAD protein signal transduction GO:0060391 TAS     cardiac septum morphogenesis GO:0060411 ISS     branching involved in salivary gland morphogenesis GO:0060445 IEA     mesenchyme development GO:0060485 ISS     negative regulation of prostatic bud formation GO:0060686 IEA     regulation of branching involved in prostate gland morphogenesis GO:0060687 IEA     chorio-allantoic fusion GO:0060710 ISS     heart trabecula morphogenesis GO:0061384 ISS     monocyte aggregation GO:0070487 IDA     cellular response to hypoxia GO:0071456 ISS     cellular response to BMP stimulus GO:0071773 IMP     negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis GO:0072040 IEA     negative regulation of glomerular mesangial cell proliferation GO:0072125 IDA     metanephric mesenchyme morphogenesis GO:0072133 IEA     nephrogenic mesenchyme morphogenesis GO:0072134 IEA     metanephric mesenchymal cell proliferation involved in metanephros development GO:0072136 IEA     positive regulation of brown fat cell differentiation GO:0090336 IMP     positive regulation of dendrite development GO:1900006 IDA     positive regulation of hyaluranon cable assembly GO:1900106 IDA     mesenchymal cell apoptotic process involved in nephron morphogenesis GO:1901145 IEA     negative regulation of non-canonical NF-kappaB signal transduction GO:1901223 ISS     allantois development GO:1905069 ISS     positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis GO:1905312 IEA     regulation of removal of superoxide radicals GO:2000121 ISS Subcellular Localization     extracellular region GO:0005576 TAS     extracellular space GO:0005615 IBA     extracellular space GO:0005615 IDA     vesicle GO:0031982 IEA     collagen-containing extracellular matrix GO:0062023 IEA