Gene description for TGFB1
Gene name	transforming growth factor, beta 1
Gene symbol	TGFB1
Other names/aliases	CED DPD1 LAP TGFB TGFbeta
Species	Homo sapiens
Database cross references - TGFB1
ExoCarta	ExoCarta_7040
Entrez Gene	7040
HGNC	11766
MIM	190180
UniProt	P01137
TGFB1 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells	Unpublished / Not applicable
Platelets	25332113
Platelets	25332113
Platelets	25332113
Prostate cancer cells	25857301
Serum	19109410

Gene ontology annotations for TGFB1

Molecular Function     growth factor activity GO:0008083 IEA     protein N-terminus binding GO:0047485 IEA     glycoprotein binding GO:0001948 IPI     antigen binding GO:0003823 IPI     enzyme binding GO:0019899 IPI     type II transforming growth factor beta receptor binding GO:0005114 IPI     protein homodimerization activity GO:0042803 IEA     protein binding GO:0005515 IPI     cytokine activity GO:0005125 TAS     protein heterodimerization activity GO:0046982 IEA     type III transforming growth factor beta receptor binding GO:0034714 IMP     type I transforming growth factor beta receptor binding GO:0034713 IPI Biological Process     positive regulation of bone mineralization GO:0030501 IEP     positive regulation of smooth muscle cell differentiation GO:0051152 IEA     hematopoietic progenitor cell differentiation GO:0002244 IDA     negative regulation of transcription, DNA-templated GO:0045892 IDA     aging GO:0007568 IEA     extrinsic apoptotic signaling pathway GO:0097191 IDA     negative regulation of cell proliferation GO:0008285 IDA     positive regulation of chemotaxis GO:0050921 IDA     response to wounding GO:0009611 IEP     platelet degranulation GO:0002576 TAS     response to drug GO:0042493 IEA     regulation of blood vessel remodeling GO:0060312 NAS     negative regulation of neuroblast proliferation GO:0007406 IEA     regulatory T cell differentiation GO:0045066 IEA     positive regulation of gene expression GO:0010628 IDA     epidermal growth factor receptor signaling pathway GO:0007173 IDA     response to estradiol GO:0032355 IDA     endoderm development GO:0007492 IEA     negative regulation of myoblast differentiation GO:0045662 IDA     protein export from nucleus GO:0006611 IDA     regulation of cartilage development GO:0061035 IEA     negative regulation of skeletal muscle tissue development GO:0048642 IDA     viral life cycle GO:0019058 TAS     positive regulation of SMAD protein import into nucleus GO:0060391 IDA     response to glucose GO:0009749 IEA     ureteric bud development GO:0001657 IEA     SMAD protein signal transduction GO:0060395 IBA     negative regulation of macrophage cytokine production GO:0010936 IDA     epithelial to mesenchymal transition GO:0001837 IEA     protein import into nucleus, translocation GO:0000060 IDA     negative regulation of extracellular matrix disassembly GO:0010716 IC     mononuclear cell proliferation GO:0032943 IEA     receptor catabolic process GO:0032801 IDA     regulation of apoptotic process GO:0042981 IBA     regulation of branching involved in mammary gland duct morphogenesis GO:0060762 IEA     tolerance induction to self antigen GO:0002513 IEA     negative regulation of mitotic cell cycle GO:0045930 IDA     regulation of binding GO:0051098 ISS     negative regulation of epithelial cell proliferation GO:0050680 IMP     modulation by virus of host morphology or physiology GO:0019048 TAS     lymph node development GO:0048535 ISS     adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 IEA     positive regulation of collagen biosynthetic process GO:0032967 IMP     regulation of cell migration GO:0030334 TAS     salivary gland morphogenesis GO:0007435 IEP     positive regulation of fibroblast migration GO:0010763 IDA     response to cholesterol GO:0070723 IDA     positive regulation of protein dephosphorylation GO:0035307 IDA     phosphate-containing compound metabolic process GO:0006796 IDA     pathway-restricted SMAD protein phosphorylation GO:0060389 IDA     regulation of striated muscle tissue development GO:0016202 ISS     positive regulation of superoxide anion generation GO:0032930 IDA     organ regeneration GO:0031100 IEA     cellular response to dexamethasone stimulus GO:0071549 IEA     cell-cell junction organization GO:0045216 IDA     regulation of actin cytoskeleton reorganization GO:2000249 IEA     SMAD protein complex assembly GO:0007183 IDA     cell development GO:0048468 IBA     chondrocyte differentiation GO:0002062 IDA     positive regulation of NAD+ ADP-ribosyltransferase activity GO:1901666 IDA     positive regulation of protein import into nucleus GO:0042307 IDA     positive regulation of MAP kinase activity GO:0043406 IDA     positive regulation of protein kinase B signaling GO:0051897 IDA     positive regulation of vascular endothelial growth factor production GO:0010575 TAS     inner ear development GO:0048839 IEA     negative regulation of transcription from RNA polymerase II promoter GO:0000122 IEA     connective tissue replacement involved in inflammatory response wound healing GO:0002248 TAS     positive regulation of protein secretion GO:0050714 IDA     response to laminar fluid shear stress GO:0034616 IEA     negative regulation of cell cycle GO:0045786 IDA     cell cycle arrest GO:0007050 IDA     extracellular matrix assembly GO:0085029 IDA     positive regulation of protein phosphorylation GO:0001934 IDA     positive regulation of peptidyl-threonine phosphorylation GO:0010800 IDA     positive regulation of interleukin-17 production GO:0032740 IDA     positive regulation of blood vessel endothelial cell migration GO:0043536 IDA     T cell homeostasis GO:0043029 IEA     negative regulation of fat cell differentiation GO:0045599 IDA     platelet activation GO:0030168 TAS     negative regulation of release of sequestered calcium ion into cytosol GO:0051280 IEA     regulation of sodium ion transport GO:0002028 IEA     SMAD protein import into nucleus GO:0007184 IDA     MAPK cascade GO:0000165 IMP     inflammatory response GO:0006954 IDA     ATP biosynthetic process GO:0006754 IDA     hyaluronan catabolic process GO:0030214 IDA     branch elongation involved in mammary gland duct branching GO:0060751 IEA     positive regulation of histone acetylation GO:0035066 IEA     response to hypoxia GO:0001666 IEA     negative regulation of cell-cell adhesion GO:0022408 IDA     mitotic cell cycle checkpoint GO:0007093 IDA     negative regulation of ossification GO:0030279 IEA     germ cell migration GO:0008354 IEA     negative regulation of cell differentiation GO:0045596 IEP     positive regulation of apoptotic process GO:0043065 IEA     negative regulation of hyaluronan biosynthetic process GO:1900126 IDA     positive regulation of cell migration GO:0030335 IDA     negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 TAS     common-partner SMAD protein phosphorylation GO:0007182 IDA     negative regulation of T cell proliferation GO:0042130 IEA     lipopolysaccharide-mediated signaling pathway GO:0031663 IDA     response to radiation GO:0009314 IEA     negative regulation of blood vessel endothelial cell migration GO:0043537 IDA     positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 IDA     positive regulation of transcription from RNA polymerase II promoter GO:0045944 IDA     cellular calcium ion homeostasis GO:0006874 IEA     protein kinase B signaling GO:0043491 IMP     regulation of transforming growth factor beta receptor signaling pathway GO:0017015 IDA     positive regulation of protein complex assembly GO:0031334 IDA     mammary gland branching involved in thelarche GO:0060744 IEA     positive regulation of histone deacetylation GO:0031065 IEA     positive regulation of NF-kappaB transcription factor activity GO:0051092 IEA     protein phosphorylation GO:0006468 ISS     active induction of host immune response by virus GO:0046732 TAS     ossification involved in bone remodeling GO:0043932 IEP     positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 IEA     evasion or tolerance of host defenses by virus GO:0019049 IDA     positive regulation of cellular protein metabolic process GO:0032270 IDA     cell growth GO:0016049 IEA     defense response to fungus, incompatible interaction GO:0009817 IEA     frontal suture morphogenesis GO:0060364 IEA     positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 IDA     positive regulation of epithelial to mesenchymal transition GO:0010718 NAS     lens fiber cell differentiation GO:0070306 IEA     blood coagulation GO:0007596 TAS     positive regulation of odontogenesis GO:0042482 IEA     negative regulation of protein phosphorylation GO:0001933 IDA     positive regulation of extracellular matrix assembly GO:1901203 IC     myeloid dendritic cell differentiation GO:0043011 IEA     positive regulation of epithelial cell proliferation GO:0050679 IEA     negative regulation of gene silencing by miRNA GO:0060965 IGI     regulation of protein import into nucleus GO:0042306 ISS     cellular response to organic cyclic compound GO:0071407 IDA     negative regulation of cell growth GO:0030308 IDA     positive regulation of transcription, DNA-templated GO:0045893 ISS     positive regulation of cell proliferation GO:0008284 IDA     extracellular matrix organization GO:0030198 TAS     positive regulation of transcription regulatory region DNA binding GO:2000679 IDA     negative regulation of gene expression GO:0010629 IGI     positive regulation of cell cycle arrest GO:0071158 IEA     positive regulation of isotype switching to IgA isotypes GO:0048298 IDA     negative regulation of phagocytosis GO:0050765 IEA     response to progesterone GO:0032570 IDA     digestive tract development GO:0048565 IEA     macrophage derived foam cell differentiation GO:0010742 IC     positive regulation of exit from mitosis GO:0031536 IEA     positive regulation of peptidyl-serine phosphorylation GO:0033138 IDA     female pregnancy GO:0007565 IEA     cellular response to transforming growth factor beta stimulus GO:0071560 IGI     transforming growth factor beta receptor signaling pathway GO:0007179 TAS     response to vitamin D GO:0033280 IEA     regulation of DNA binding GO:0051101 ISS     face morphogenesis GO:0060325 IEA     negative regulation of DNA replication GO:0008156 IMP     myelination GO:0042552 IEA Subcellular Localization     platelet alpha granule lumen GO:0031093 TAS     cytoplasm GO:0005737 IDA     extracellular space GO:0005615 IDA     microvillus GO:0005902 IDA     cell surface GO:0009986 IMP     proteinaceous extracellular matrix GO:0005578 ISS     nucleus GO:0005634 IDA     blood microparticle GO:0072562 IDA     extracellular region GO:0005576 TAS     axon GO:0030424 IEA     Golgi lumen GO:0005796 TAS     plasma membrane GO:0005886 TAS     neuronal cell body GO:0043025 IEA