Gene description for GIT2
Gene name G protein-coupled receptor kinase interacting ArfGAP 2
Gene symbol GIT2
Other names/aliases CAT-2
CAT2
Species Homo sapiens
 Database cross references - GIT2
ExoCarta ExoCarta_9815
Vesiclepedia VP_9815
Entrez Gene 9815
HGNC 4273
MIM 608564
UniProt Q14161  
 GIT2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for GIT2
Molecular Function
    GTPase activator activity GO:0005096 IBA
    protein binding GO:0005515 IPI
    small GTPase binding GO:0031267 IBA
    metal ion binding GO:0046872 IEA
Biological Process
    brain development GO:0007420 IBA
    regulation of G protein-coupled receptor signaling pathway GO:0008277 IBA
    regulation of ARF protein signal transduction GO:0032012 IBA
    synaptic vesicle recycling GO:0036465 IBA
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    focal adhesion GO:0005925 HDA
    synapse GO:0045202 IBA
    presynapse GO:0098793 IEA
 Experiment description of studies that identified GIT2 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for GIT2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ADRBK1 156
Affinity Capture-Western Homo sapiens
2 MVP 9961
Two-hybrid Homo sapiens
3 TNFAIP3 7128
Two-hybrid Homo sapiens
4 SKP1 6500
Affinity Capture-MS Homo sapiens
5 TNIP1 10318
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
6 MAFF 23764
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 ZNHIT1  
Affinity Capture-MS Homo sapiens
8 RCVRN  
Two-hybrid Homo sapiens
9 CCDC132 55610
Affinity Capture-MS Homo sapiens
10 GIT2 9815
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
11 PAK2 5062
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 GRIPAP1 56850
Affinity Capture-MS Homo sapiens
13 C4BPA 722
Two-hybrid Homo sapiens
14 TUFT1  
Affinity Capture-MS Homo sapiens
15 RABGGTB 5876
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 ARNTL  
Affinity Capture-MS Homo sapiens
17 NUF2  
Affinity Capture-MS Homo sapiens
18 E2F2 1870
Two-hybrid Homo sapiens
19 TAX1BP3 30851
Affinity Capture-MS Homo sapiens
20 CORO1A 11151
Two-hybrid Homo sapiens
21 EXOC1 55763
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 FBXW7  
Affinity Capture-MS Homo sapiens
23 SCRIB 23513
Affinity Capture-MS Homo sapiens
24 PSMD9 5715
Affinity Capture-MS Homo sapiens
25 FBXO28  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 PROX1  
Two-hybrid Homo sapiens
27 YWHAG 7532
Affinity Capture-MS Homo sapiens
28 UBQLN1 29979
Two-hybrid Homo sapiens
29 HAUS6  
Affinity Capture-MS Homo sapiens
30 CENPQ  
Affinity Capture-MS Homo sapiens
31 GUSB 2990
Two-hybrid Homo sapiens
32 YWHAH 7533
Affinity Capture-MS Homo sapiens
33 ATG16L1 55054
Affinity Capture-MS Homo sapiens
34 VPS53 55275
Affinity Capture-MS Homo sapiens
35 NME2 4831
Two-hybrid Homo sapiens
36 CALCOCO2  
Two-hybrid Homo sapiens
37 SNX27 81609
Affinity Capture-MS Homo sapiens
38 NCK1 4690
Affinity Capture-MS Homo sapiens
39 PAK1 5058
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
40 PFN1 5216
Proximity Label-MS Homo sapiens
41 EDC4 23644
Two-hybrid Homo sapiens
42 KRT8 3856
Proximity Label-MS Homo sapiens
43 CLOCK  
Affinity Capture-MS Homo sapiens
44 RUSC2 9853
Two-hybrid Homo sapiens
45 NCKIPSD 51517
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 RUFY1 80230
Two-hybrid Homo sapiens
47 QPRT 23475
Two-hybrid Homo sapiens
48 VPS51 738
Affinity Capture-MS Homo sapiens
49 RABEP1 9135
Affinity Capture-MS Homo sapiens
50 OIP5  
Affinity Capture-MS Homo sapiens
51 GCH1  
Two-hybrid Homo sapiens
52 GIT1 28964
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Co-localization Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 SAFB2 9667
Two-hybrid Homo sapiens
54 SYNC  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 SMAD3 4088
Two-hybrid Homo sapiens
56 PCLO 27445
Two-hybrid Homo sapiens
57 ARHGEF6 9459
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 GET4 51608
Two-hybrid Homo sapiens
59 ACTG1 71
Two-hybrid Homo sapiens
60 UBXN6 80700
Affinity Capture-MS Homo sapiens
61 ATF5  
Two-hybrid Homo sapiens
62 YEATS4  
Affinity Capture-MS Homo sapiens
63 NCKAP5L  
Affinity Capture-MS Homo sapiens
64 ACTN1 87
Two-hybrid Homo sapiens
65 TSSC1 7260
Affinity Capture-MS Homo sapiens
66 PHLDB3  
Affinity Capture-MS Homo sapiens
67 ICAM1 3383
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
68 TMOD4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 LMNB1 4001
Two-hybrid Homo sapiens
70 HGD 3081
Two-hybrid Homo sapiens
71 ASS1 445
Co-fractionation Homo sapiens
72 SLC9A3R2 9351
Affinity Capture-MS Homo sapiens
73 RPRD1A  
Affinity Capture-MS Homo sapiens
74 TFPT  
Affinity Capture-MS Homo sapiens
75 HNRNPUL1 11100
Two-hybrid Homo sapiens
76 PKN3 29941
Affinity Capture-MS Homo sapiens
77 CAMK4 814
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
78 CSNK2A2 1459
Affinity Capture-MS Homo sapiens
79 PHF21A  
Affinity Capture-MS Homo sapiens
80 TSN 7247
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
81 RABGAP1L 9910
Affinity Capture-MS Homo sapiens
82 SH3GLB2 56904
Two-hybrid Homo sapiens
83 USHBP1  
Two-hybrid Homo sapiens
84 HMG20A  
Affinity Capture-MS Homo sapiens
85 KLHL2 11275
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
86 ARHGEF7 8874
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
87 DZIP3  
Affinity Capture-MS Homo sapiens
88 KRT18 3875
Two-hybrid Homo sapiens
89 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
90 SPOP  
Two-hybrid Homo sapiens
91 MAX  
Affinity Capture-MS Homo sapiens
92 POLR1B 84172
Two-hybrid Homo sapiens
93 CCHCR1  
Affinity Capture-MS Homo sapiens
94 IKBKG 8517
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
95 PFDN1 5201
Affinity Capture-MS Homo sapiens
96 THAP11 57215
Affinity Capture-MS Homo sapiens
97 DDX58 23586
Affinity Capture-RNA Homo sapiens
98 CCDC93 54520
Affinity Capture-MS Homo sapiens
99 LPXN 9404
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
100 NCK2 8440
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
101 TMEM154  
Affinity Capture-MS Homo sapiens
102 RABGEF1 27342
Affinity Capture-MS Homo sapiens
103 MOV10 4343
Affinity Capture-RNA Homo sapiens
104 FGFR1OP2  
Affinity Capture-MS Homo sapiens
105 GOLGA5 9950
Affinity Capture-MS Homo sapiens
106 PXN 5829
Proximity Label-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
107 KXD1 79036
Affinity Capture-MS Homo sapiens
108 NFKBIB  
Two-hybrid Homo sapiens
109 PTRF 284119
Affinity Capture-MS Homo sapiens
110 KCTD5 54442
Two-hybrid Homo sapiens
111 RCOR1  
Affinity Capture-MS Homo sapiens
112 TRAF1 7185
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml



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