Gene description for ERBB2IP
Gene name erbb2 interacting protein
Gene symbol ERBB2IP
Other names/aliases ERBIN
HEL-S-78
LAP2
Species Homo sapiens
 Database cross references - ERBB2IP
ExoCarta ExoCarta_55914
Vesiclepedia VP_55914
Entrez Gene 55914
HGNC 15842
MIM 606944
UniProt Q96RT1  
 ERBB2IP identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Melanoma cells 22635005    
Melanoma cells 25950383    
Melanoma cells 25950383    
Melanoma cells 25950383    
Mesenchymal stem cells 36408942    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
Prostate cancer cells 25844599    
Thymus 23844026    
 Gene ontology annotations for ERBB2IP
Molecular Function
    signaling receptor binding GO:0005102 IPI
    ErbB-2 class receptor binding GO:0005176 TAS
    structural constituent of cytoskeleton GO:0005200 NAS
    protein binding GO:0005515 IPI
Biological Process
    protein targeting GO:0006605 IEA
    cell adhesion GO:0007155 NAS
    signal transduction GO:0007165 TAS
    epidermal growth factor receptor signaling pathway GO:0007173 TAS
    integrin-mediated signaling pathway GO:0007229 NAS
    negative regulation of NF-kappaB transcription factor activity GO:0032088 IMP
    response to muramyl dipeptide GO:0032495 IMP
    response to lipopolysaccharide GO:0032496 IMP
    intracellular signal transduction GO:0035556 IBA
    intermediate filament cytoskeleton organization GO:0045104 NAS
    basal protein localization GO:0045175 NAS
    establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 NAS
    negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway GO:0070433 IBA
    negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway GO:0070433 IMP
    cellular response to tumor necrosis factor GO:0071356 IMP
    negative regulation of monocyte chemotactic protein-1 production GO:0071638 IEA
    regulation of postsynaptic membrane neurotransmitter receptor levels GO:0099072 IEA
Subcellular Localization
    basement membrane GO:0005604 TAS
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 IDA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    basal plasma membrane GO:0009925 NAS
    basolateral plasma membrane GO:0016323 IDA
    nuclear speck GO:0016607 IDA
    cell junction GO:0030054 IDA
    hemidesmosome GO:0030056 IDA
    neuromuscular junction GO:0031594 IEA
    nuclear membrane GO:0031965 IEA
    glutamatergic synapse GO:0098978 IEA
    postsynaptic specialization GO:0099572 IEA
 Experiment description of studies that identified ERBB2IP in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
7
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
8
Experiment ID 200
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|TSG101|Alix|GAPDH
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22635005    
Organism Homo sapiens
Experiment description Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET.
Authors "Peinado H, Aleckovic M, Lavotshkin S, Matei I, Costa-Silva B, Moreno-Bueno G, Hergueta-Redondo M, Williams C, Garcia-Santos G, Ghajar C, Nitadori-Hoshino A, Hoffman C, Badal K, Garcia BA, Callahan MK, Yuan J, Martins VR, Skog J, Kaplan RN, Brady MS, Wolchok JD, Chapman PB, Kang Y, Bromberg J, Lyden D."
Journal name Nat Med
Publication year 2012
Sample Melanoma cells
Sample name B16-F10
SK-MEL-202
SK-MEL035
SK-MEL-265
Isolation/purification methods Differential centrifugation
Filtration
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
9
Experiment ID 258
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|FLOT1|CD81
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name SKMEL28
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
10
Experiment ID 259
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|FLOT1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name A375M
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
11
Experiment ID 260
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|FLOT1|CD81
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name 1205Lu
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
12
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
13
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
14
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
15
Experiment ID 231
MISEV standards
✘ Biophysical techniques
✔
Alix|CD63|CD9
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
16
Experiment ID 232
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
17
Experiment ID 233
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
18
Experiment ID 275
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
✔
AIF
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
19
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ERBB2IP
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GJD3  
Proximity Label-MS Homo sapiens
2 PPP1R3A  
Affinity Capture-MS Homo sapiens
3 OCLN 100506658
Proximity Label-MS Homo sapiens
4 MARCKS 4082
Proximity Label-MS Homo sapiens
5 WWP1 11059
Affinity Capture-MS Homo sapiens
6 Cdh1 12550
Affinity Capture-MS Mus musculus
7 GJA1 2697
Proximity Label-MS Homo sapiens
8 PARD3 56288
Proximity Label-MS Homo sapiens
9 APC  
Two-hybrid Homo sapiens
10 DBN1 1627
Affinity Capture-MS Homo sapiens
11 HRAS 3265
Affinity Capture-Western Homo sapiens
12 KIF20A 10112
Affinity Capture-MS Homo sapiens
13 STX4 6810
Proximity Label-MS Homo sapiens
14 ZNF414  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 PPP1CC 5501
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 LMO2  
Two-hybrid Homo sapiens
17 MLLT4 4301
Proximity Label-MS Homo sapiens
18 ZNF408  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 LRRC1 55227
Reconstituted Complex Homo sapiens
20 HOXA5  
Affinity Capture-MS Homo sapiens
21 CERKL  
Affinity Capture-MS Homo sapiens
22 ZNF460  
Affinity Capture-MS Homo sapiens
23 STAT3 6774
Two-hybrid Homo sapiens
24 STX6 10228
Proximity Label-MS Homo sapiens
25 ARHGAP19  
Affinity Capture-MS Homo sapiens
26 CLTC 1213
Affinity Capture-MS Homo sapiens
27 GTSE1 51512
Affinity Capture-MS Homo sapiens
28 LIMK1 3984
Affinity Capture-MS Homo sapiens
29 C2CD4B  
Affinity Capture-MS Homo sapiens
30 RAB35 11021
Proximity Label-MS Homo sapiens
31 BTRC 8945
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
32 ERBB2 2064
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
33 ZFYVE9  
Two-hybrid Homo sapiens
34 KCNA4  
Reconstituted Complex Homo sapiens
35 KIF14 9928
Affinity Capture-MS Homo sapiens
36 KLF9 687
Affinity Capture-MS Homo sapiens
37 RAB5A 5868
Proximity Label-MS Homo sapiens
38 TRIM41 90933
Affinity Capture-MS Homo sapiens
39 PPP1CA 5499
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 HOXA7  
Affinity Capture-MS Homo sapiens
41 ZNF444  
Affinity Capture-MS Homo sapiens
42 RBX1 9978
Biochemical Activity Homo sapiens
43 Cep44  
Affinity Capture-MS Mus musculus
44 LYN 4067
Proximity Label-MS Homo sapiens
45 Sec24c  
Affinity Capture-MS Mus musculus
46 MCAM 4162
Proximity Label-MS Homo sapiens
47 CBL 867
Affinity Capture-Western Homo sapiens
48 DNAJC5 80331
Proximity Label-MS Homo sapiens
49 MUSK  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
50 CDH1 999
Proximity Label-MS Homo sapiens
51 CHMP4B 128866
Affinity Capture-MS Homo sapiens
52 Ppp1r3b  
Affinity Capture-MS Mus musculus
53 SMAD3 4088
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
54 DTX2 113878
Proximity Label-MS Homo sapiens
55 SMAD2 4087
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
56 ZNF563  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 ZNF581  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 ADAMTS1 9510
Affinity Capture-MS Homo sapiens
59 TRMT2A 27037
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 DDX39B 7919
Affinity Capture-MS Homo sapiens
61 CXADR 1525
Proximity Label-MS Homo sapiens
62 YWHAE 7531
Affinity Capture-MS Homo sapiens
63 ANLN 54443
Affinity Capture-MS Homo sapiens
64 DST 667
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
65 PICK1  
Two-hybrid Homo sapiens
66 CTSK 1513
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 XPO1 7514
Affinity Capture-MS Homo sapiens
68 ECT2 1894
Affinity Capture-MS Homo sapiens
69 ERBB2IP 55914
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
70 ARVCF 421
Reconstituted Complex Homo sapiens
71 EPB41L4A 64097
Proximity Label-MS Homo sapiens
72 CTNNB1 1499
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
73 CUL3 8452
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 YWHAZ 7534
Affinity Capture-MS Homo sapiens
75 HOXB7 3217
Affinity Capture-MS Homo sapiens
76 GRIN2C 2905
Reconstituted Complex Homo sapiens
77 MYO19  
Affinity Capture-MS Homo sapiens
78 ZNF707  
Affinity Capture-MS Homo sapiens
79 GDF15 9518
Affinity Capture-MS Homo sapiens
80 RIPK4  
Affinity Capture-MS Homo sapiens
81 Cep152  
Affinity Capture-MS Mus musculus
82 AURKB 9212
Affinity Capture-MS Homo sapiens
83 SMAD1 4086
Reconstituted Complex Homo sapiens
84 KCNE3  
Affinity Capture-MS Homo sapiens
85 ABTB2 25841
Affinity Capture-MS Homo sapiens
86 MYC  
Affinity Capture-MS Homo sapiens
87 RPA3 6119
Proximity Label-MS Homo sapiens
88 GRIN2B  
Reconstituted Complex Homo sapiens
89 TMCO1 54499
Cross-Linking-MS (XL-MS) Homo sapiens
90 PKP4 8502
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
91 AZU1 566
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
92 PDX1  
Affinity Capture-MS Homo sapiens
93 HOXC4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
94 ITGB4 3691
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
95 OBP2A 29991
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
96 EBAG9 9166
Proximity Label-MS Homo sapiens
97 RHOB 388
Proximity Label-MS Homo sapiens
98 XRCC3  
Affinity Capture-MS Homo sapiens
99 CTNNA1 1495
Proximity Label-MS Homo sapiens
100 CHUK 1147
Biochemical Activity Homo sapiens
101 FLOT1 10211
Proximity Label-MS Homo sapiens
102 SUGT1 10910
Affinity Capture-MS Homo sapiens
103 RNF43  
Proximity Label-MS Homo sapiens
104 INHBE 83729
Affinity Capture-MS Homo sapiens
105 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
106 ZNF785  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
107 PDZD2  
Affinity Capture-Western Homo sapiens
108 SMAD7  
Reconstituted Complex Homo sapiens
109 ZNF264  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
110 Pkp4  
Two-hybrid Mus musculus
111 HOXB6 3216
Affinity Capture-MS Homo sapiens
112 EZR 7430
Proximity Label-MS Homo sapiens
113 MEN1 4221
Affinity Capture-MS Homo sapiens
114 RPAP1  
Affinity Capture-MS Homo sapiens
115 LCK 3932
Proximity Label-MS Homo sapiens
116 SMAD4  
Reconstituted Complex Homo sapiens
117 CCDC106  
Affinity Capture-MS Homo sapiens
118 ZNF764 92595
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
119 C11orf52 91894
Proximity Label-MS Homo sapiens
120 RNF7  
Biochemical Activity Homo sapiens
121 Samm50  
Affinity Capture-MS Mus musculus
122 Erbb2  
Two-hybrid Mus musculus
123 HOXC9  
Affinity Capture-MS Homo sapiens
124 IL17B 27190
Affinity Capture-MS Homo sapiens
125 NTN5  
Affinity Capture-MS Homo sapiens
126 ZNF517  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
127 EPHA2 1969
Proximity Label-MS Homo sapiens
128 ZNF550  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
129 KRAS 3845
Proximity Label-MS Homo sapiens
130 CAV1 857
Proximity Label-MS Homo sapiens
131 CTNND1 1500
Reconstituted Complex Homo sapiens
132 MAFB  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ERBB2IP is involved
PathwayEvidenceSource
Constitutive Signaling by Overexpressed ERBB2 TAS Reactome
Disease TAS Reactome
Diseases of signal transduction by growth factor receptors and second messengers TAS Reactome
Downregulation of ERBB2 signaling TAS Reactome
Drug resistance in ERBB2 KD mutants TAS Reactome
Drug resistance in ERBB2 TMD/JMD mutants TAS Reactome
Drug-mediated inhibition of ERBB2 signaling TAS Reactome
RAC1 GTPase cycle TAS Reactome
RAC2 GTPase cycle TAS Reactome
RAC3 GTPase cycle TAS Reactome
Resistance of ERBB2 KD mutants to AEE788 TAS Reactome
Resistance of ERBB2 KD mutants to afatinib TAS Reactome
Resistance of ERBB2 KD mutants to lapatinib TAS Reactome
Resistance of ERBB2 KD mutants to neratinib TAS Reactome
Resistance of ERBB2 KD mutants to osimertinib TAS Reactome
Resistance of ERBB2 KD mutants to sapitinib TAS Reactome
Resistance of ERBB2 KD mutants to tesevatinib TAS Reactome
Resistance of ERBB2 KD mutants to trastuzumab TAS Reactome
RHO GTPase cycle TAS Reactome
RHOA GTPase cycle TAS Reactome
RHOB GTPase cycle TAS Reactome
RHOC GTPase cycle TAS Reactome
RHOG GTPase cycle TAS Reactome
Signal Transduction TAS Reactome
Signaling by ERBB2 TAS Reactome
Signaling by ERBB2 ECD mutants TAS Reactome
Signaling by ERBB2 in Cancer TAS Reactome
Signaling by ERBB2 KD Mutants TAS Reactome
Signaling by ERBB2 TMD/JMD mutants TAS Reactome
Signaling by Receptor Tyrosine Kinases TAS Reactome
Signaling by Rho GTPases TAS Reactome
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 TAS Reactome





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