Gene description for ASPM
Gene name asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
Gene symbol ASPM
Other names/aliases ASP
Calmbp1
MCPH5
Species Homo sapiens
 Database cross references - ASPM
ExoCarta ExoCarta_259266
Vesiclepedia VP_259266
Entrez Gene 259266
HGNC 19048
MIM 605481
UniProt Q8IZT6  
 ASPM identified in exosomes derived from the following tissue/cell type
Endothelial cells 26027894    
 Gene ontology annotations for ASPM
Molecular Function
    calmodulin binding GO:0005516 IEA
Biological Process
    neuron migration GO:0001764 IEA
    positive regulation of neuroblast proliferation GO:0002052 IEA
    spindle organization GO:0007051 IMP
    spermatogenesis GO:0007283 IEA
    asymmetric cell division GO:0008356 IEA
    male gonad development GO:0008584 IEA
    forebrain neuroblast division GO:0021873 IEA
    cerebral cortex development GO:0021987 IEA
    negative regulation of neuron differentiation GO:0045665 IEA
    negative regulation of asymmetric cell division GO:0045769 IEA
    oogenesis GO:0048477 IEA
    developmental growth GO:0048589 IEA
    regulation of meiotic cell cycle GO:0051445 IEA
    spindle localization GO:0051653 IMP
    maintenance of centrosome location GO:0051661 IEA
    positive regulation of canonical Wnt signaling pathway GO:0090263 IEA
    meiotic spindle assembly GO:0090306 IEA
    neuronal stem cell population maintenance GO:0097150 IEA
Subcellular Localization
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 IEA
    centrosome GO:0005813 IEA
    apical plasma membrane GO:0016324 IEA
    midbody GO:0030496 IEA
    microtubule minus-end GO:0036449 IDA
    meiotic spindle GO:0072687 IEA
    mitotic spindle pole GO:0097431 IDA
 Experiment description of studies that identified ASPM in exosomes
1
Experiment ID 226
MISEV standards
EM
Biophysical techniques
GAPDH|CD9|FLOT1
Enriched markers
LMNA|H2AFX|ATP5A1|TOMM20
Negative markers
Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description "Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting"
Authors "Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar"
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
 Protein-protein interactions for ASPM
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CENPB 1059
Affinity Capture-MS Homo sapiens
2 LIG4 3981
Two-hybrid Homo sapiens
3 PRKAA1 5562
Affinity Capture-MS Homo sapiens
4 IARS2 55699
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 TEX13A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 CNKSR1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 IPO7 10527
Affinity Capture-MS Homo sapiens
8 FOXJ1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 MOAP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 PHLPP1  
Proximity Label-MS Homo sapiens
11 TRIM66  
Affinity Capture-MS Homo sapiens
12 ACTC1 70
Proximity Label-MS Homo sapiens
13 LIMS1 3987
Affinity Capture-MS Homo sapiens
14 Ndc80  
Affinity Capture-MS Mus musculus
15 UBE3A 7337
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
16 CALM1 801
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 DNAJB6 10049
Proximity Label-MS Homo sapiens
18 LRPPRC 10128
Cross-Linking-MS (XL-MS) Homo sapiens
19 HSPA4 3308
Affinity Capture-MS Homo sapiens
20 CDC16 8881
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 CRYZ 1429
Affinity Capture-MS Homo sapiens
22 ATP1A3 478
Cross-Linking-MS (XL-MS) Homo sapiens
23 KIF23 9493
Affinity Capture-MS Homo sapiens
24 MXD3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 ZNF460  
Affinity Capture-MS Homo sapiens
26 CALM3 808
Affinity Capture-MS Homo sapiens
27 MAGEA9  
Affinity Capture-MS Homo sapiens
28 MID2 11043
Affinity Capture-MS Homo sapiens
29 MAP3K6  
Affinity Capture-MS Homo sapiens
30 NAP1L4 4676
Affinity Capture-MS Homo sapiens
31 SNX7 51375
Affinity Capture-MS Homo sapiens
32 FSD2 123722
Affinity Capture-MS Homo sapiens
33 SSR3 6747
Affinity Capture-MS Homo sapiens
34 CRTAC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 GNB5 10681
Negative Genetic Homo sapiens
36 CCDC83  
Affinity Capture-MS Homo sapiens
37 KIF14 9928
Affinity Capture-MS Homo sapiens
38 RNF135  
Negative Genetic Homo sapiens
39 CCDC114  
Affinity Capture-MS Homo sapiens
40 GPN3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 TP53INP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 AURKA 6790
Affinity Capture-MS Homo sapiens
43 PPP1CA 5499
Reconstituted Complex Homo sapiens
44 SLC25A10 1468
Affinity Capture-MS Homo sapiens
45 TSGA10IP  
Affinity Capture-MS Homo sapiens
46 TRAFD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 PPP6R2 9701
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 SDCCAG3  
Affinity Capture-MS Homo sapiens
49 PTPRS 5802
Negative Genetic Homo sapiens
50 EIF2B5 8893
Affinity Capture-MS Homo sapiens
51 CSRNP1  
Affinity Capture-MS Homo sapiens
52 DNAJB7  
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 RSPH6A  
Affinity Capture-MS Homo sapiens
54 DNAJB8  
Affinity Capture-MS Homo sapiens
55 DTNBP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 TUBA1B 10376
Affinity Capture-MS Homo sapiens
57 CDH5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 ZNF333  
Affinity Capture-MS Homo sapiens
59 IFI16 3428
Affinity Capture-MS Homo sapiens
60 PNMA2  
Affinity Capture-MS Homo sapiens
61 CREB3  
Affinity Capture-MS Homo sapiens
62 STIL  
Proximity Label-MS Homo sapiens
63 HECTD1 25831
Affinity Capture-MS Homo sapiens
64 COPS7B 64708
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 DNAJB5  
Proximity Label-MS Homo sapiens
66 HAUS7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 PIPSL 266971
Affinity Capture-MS Homo sapiens
68 STK32C  
Affinity Capture-MS Homo sapiens
69 INTS4P2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 ANLN 54443
Affinity Capture-MS Homo sapiens
71 DKK3 27122
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 NUMA1 4926
Affinity Capture-MS Homo sapiens
73 PER2  
Affinity Capture-MS Homo sapiens
74 PSMA3 5684
Affinity Capture-MS Homo sapiens
75 TUBGCP5 114791
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
76 Prkcz  
Affinity Capture-MS Mus musculus
77 ECT2 1894
Affinity Capture-MS Homo sapiens
78 NCAPH2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
79 PSMD8 5714
Co-fractionation Homo sapiens
80 CTNNB1 1499
Affinity Capture-MS Homo sapiens
81 ANO3  
Affinity Capture-MS Homo sapiens
82 SPC24 147841
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
83 CUL3 8452
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
84 NAP1L1 4673
Affinity Capture-MS Homo sapiens
85 TP73  
Affinity Capture-Western Homo sapiens
86 RCN1 5954
Affinity Capture-MS Homo sapiens
87 GPRASP2  
Affinity Capture-MS Homo sapiens
88 PACS2 23241
Affinity Capture-MS Homo sapiens
89 LZTS2 84445
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
90 INPP5K 51763
Negative Genetic Homo sapiens
91 MAPK6  
Affinity Capture-MS Homo sapiens
92 RRAS 6237
Negative Genetic Homo sapiens
93 SET 6418
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
94 MTOR 2475
Affinity Capture-MS Homo sapiens
95 TP63  
Affinity Capture-Western Homo sapiens
96 FAM46A  
Affinity Capture-MS Homo sapiens
97 NDC80 10403
Proximity Label-MS Homo sapiens
98 PSMC5 5705
Affinity Capture-MS Homo sapiens
99 RCN2 5955
Affinity Capture-MS Homo sapiens
100 NEUROG3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
101 PMS2P3  
Affinity Capture-MS Homo sapiens
102 FTL 2512
Affinity Capture-MS Homo sapiens
103 FEZ1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
104 FASN 2194
Negative Genetic Homo sapiens
105 TP53 7157
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
106 MAPK8IP2  
Affinity Capture-MS Homo sapiens
107 PEX19 5824
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
108 TRIM52  
Affinity Capture-MS Homo sapiens
109 CALU 813
Affinity Capture-MS Homo sapiens
110 ELL  
Affinity Capture-MS Homo sapiens
111 CPPED1 55313
Negative Genetic Homo sapiens
112 OS9 10956
Affinity Capture-MS Homo sapiens
113 MYL2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
114 THAP7  
Affinity Capture-MS Homo sapiens
115 SKAP1 8631
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
116 CALM2 805
Affinity Capture-MS Homo sapiens
117 KRT38 8687
Affinity Capture-MS Homo sapiens
118 HLA-DPA1  
Affinity Capture-MS Homo sapiens
119 CDK4 1019
Affinity Capture-MS Homo sapiens
120 EAF1  
Affinity Capture-MS Homo sapiens
121 ZCCHC10  
Affinity Capture-MS Homo sapiens
122 CEP78 84131
Affinity Capture-MS Homo sapiens
123 EID1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
124 KRAS 3845
Synthetic Lethality Homo sapiens
125 RPP38 10557
Affinity Capture-MS Homo sapiens
126 LURAP1  
Affinity Capture-MS Homo sapiens
127 INTU  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ASPM is involved
No pathways found





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