Gene description for THRB
Gene name thyroid hormone receptor, beta
Gene symbol THRB
Other names/aliases C-ERBA-2
C-ERBA-BETA
ERBA2
GRTH
NR1A2
PRTH
THR1
THRB1
THRB2
Species Homo sapiens
 Database cross references - THRB
ExoCarta ExoCarta_7068
Entrez Gene 7068
HGNC 11799
MIM 190160
UniProt P10828  
 THRB identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
Hepatocytes 26054723    
 Gene ontology annotations for THRB
Molecular Function
    thyroid hormone binding GO:0070324 IDA
    protein binding GO:0005515 IPI
    DNA binding GO:0003677 TAS
    steroid hormone receptor activity GO:0003707 IEA
    chromatin DNA binding GO:0031490 IEA
    enzyme binding GO:0019899 IPI
    transcription corepressor activity GO:0003714 TAS
    sequence-specific DNA binding transcription factor activity GO:0003700 NAS
    zinc ion binding GO:0008270 IEA
    thyroid hormone receptor activity GO:0004887 IDA
    sequence-specific DNA binding GO:0043565 IEA
Biological Process
    organ morphogenesis GO:0009887 IEA
    negative regulation of female receptivity GO:0007621 IEA
    transcription, DNA-templated GO:0006351 TAS
    female courtship behavior GO:0008050 IEA
    transcription initiation from RNA polymerase II promoter GO:0006367 TAS
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IEA
    Type I pneumocyte differentiation GO:0060509 IEA
    sensory perception of sound GO:0007605 IEA
    gene expression GO:0010467 TAS
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IEA
    regulation of heart contraction GO:0008016 IEA
    intracellular receptor signaling pathway GO:0030522 TAS
    steroid hormone mediated signaling pathway GO:0043401 IEA
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    nucleoplasm GO:0005654 TAS
    nuclear chromatin GO:0000790 IEA
    nucleus GO:0005634 TAS
 Experiment description of studies that identified THRB in exosomes
1
Experiment ID 235
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
2
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for THRB
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NCOA6  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
2 NR2F6  
Invitro Homo sapiens
Invivo Homo sapiens
Two-hybrid Homo sapiens
3 COPS2 9318
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
4 Hdac2  
Reconstituted Complex Mus musculus
5 NCOA1  
Invitro Homo sapiens
Two-hybrid Homo sapiens
6 EIF3I 8668
Two-hybrid Homo sapiens
7 BRD8 10902
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
8 TSG101 7251
Two-hybrid Homo sapiens
9 NCOA2 10499
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
10 RXRG  
Invivo Homo sapiens
11 NCOR2  
Invitro Homo sapiens
12 RXRA  
Reconstituted Complex Homo sapiens
13 TP53  
Affinity Capture-Western Homo sapiens
14 NRBF2  
Two-hybrid Homo sapiens
15 PPARGC1B  
Reconstituted Complex Homo sapiens
16 TBL1X 6907
Reconstituted Complex Homo sapiens
17 PSMC5 5705
Two-hybrid Homo sapiens
18 SRC 6714
Reconstituted Complex Homo sapiens
19 CCND1 595
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
20 PPARGC1A  
Invitro Homo sapiens
21 TRIP4  
Reconstituted Complex Homo sapiens
22 PRMT1 3276
Reconstituted Complex Homo sapiens
23 PPARBP  
Invivo Homo sapiens
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which THRB is involved
PathwayEvidenceSource
Nuclear Receptor transcription pathway TAS Reactome





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