Gene description for STRN
Gene name striatin, calmodulin binding protein
Gene symbol STRN
Other names/aliases SG2NA
Species Homo sapiens
 Database cross references - STRN
ExoCarta ExoCarta_6801
Vesiclepedia VP_6801
Entrez Gene 6801
HGNC 11424
MIM 614765
UniProt O43815  
 STRN identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for STRN
Molecular Function
    protein binding GO:0005515 IPI
    calmodulin binding GO:0005516 IBA
    calmodulin binding GO:0005516 ISS
    calmodulin binding GO:0005516 NAS
    nuclear estrogen receptor binding GO:0030331 IPI
    protein-containing complex binding GO:0044877 IBA
    protein-containing complex binding GO:0044877 IDA
    protein phosphatase 2A binding GO:0051721 IBA
    protein phosphatase 2A binding GO:0051721 IDA
    armadillo repeat domain binding GO:0070016 IPI
Biological Process
    locomotory behavior GO:0007626 ISS
    negative regulation of cell population proliferation GO:0008285 IMP
    regulation of signal transduction GO:0009966 IBA
    Wnt signaling pathway GO:0016055 IBA
    Wnt signaling pathway GO:0016055 IMP
    dendrite development GO:0016358 ISS
    bicellular tight junction assembly GO:0070830 NAS
Subcellular Localization
    cytosol GO:0005829 TAS
    bicellular tight junction GO:0005923 IDA
    postsynaptic density GO:0014069 ISS
    membrane GO:0016020 ISS
    dendrite GO:0030425 IBA
    neuronal cell body GO:0043025 ISS
    dendritic spine GO:0043197 ISS
    postsynaptic membrane GO:0045211 ISS
    FAR/SIN/STRIPAK complex GO:0090443 IBA
    FAR/SIN/STRIPAK complex GO:0090443 IDA
 Experiment description of studies that identified STRN in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for STRN
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TRAF3IP3  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 LYPD3 27076
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 STK25 10494
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 CCT3 7203
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 SNX24  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 PAXIP1  
Affinity Capture-MS Homo sapiens
7 SIKE1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 Strip1  
Affinity Capture-MS Mus musculus
9 RABEP2 79874
Affinity Capture-MS Homo sapiens
10 APC  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
11 BRCA1 672
Affinity Capture-MS Homo sapiens
12 STRN3 29966
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
13 GOLGA6A  
Affinity Capture-MS Homo sapiens
14 MAP4K4 9448
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 CSNK2A1 1457
Affinity Capture-MS Homo sapiens
16 CCT6B 10693
Affinity Capture-MS Homo sapiens
17 MINK1 50488
Affinity Capture-MS Homo sapiens
18 PPP2R2C 5522
Affinity Capture-MS Homo sapiens
19 TUFT1  
Affinity Capture-MS Homo sapiens
20 RTN4 57142
Affinity Capture-MS Homo sapiens
21 SF3B5 83443
Co-fractionation Homo sapiens
22 KIAA1429 25962
Affinity Capture-MS Homo sapiens
23 PDCD10 11235
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 PPP2R1B 5519
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 STRN4 29888
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
26 EXOC1 55763
Affinity Capture-MS Homo sapiens
27 CALD1 800
Affinity Capture-MS Homo sapiens
28 TFIP11  
Two-hybrid Homo sapiens
29 DYNLL1 8655
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 TULP3 7289
Affinity Capture-MS Homo sapiens
31 ATG16L1 55054
Affinity Capture-MS Homo sapiens
32 STRIP1 85369
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 PKN3 29941
Affinity Capture-MS Homo sapiens
34 CTTNBP2NL  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Proximity Label-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 CCT5 22948
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 CCT2 10576
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 Arrb2  
Affinity Capture-MS Mus musculus
38 ZNF550  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 TCP1 6950
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 MCC 4163
Affinity Capture-MS Homo sapiens
41 MOB4 25843
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
42 PGAM5 192111
Affinity Capture-MS Homo sapiens
43 NR1H3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 GOLGA8G  
Affinity Capture-MS Homo sapiens
45 GOLGA2 2801
Proximity Label-MS Homo sapiens
46 Ppp2ca 19052
Affinity Capture-MS Mus musculus
47 EEF1E1 9521
Affinity Capture-MS Homo sapiens
48 CAMK2B 816
Affinity Capture-MS Homo sapiens
49 SLC43A3 29015
Affinity Capture-MS Homo sapiens
50 NTRK1 4914
Affinity Capture-MS Homo sapiens
51 PPP2CA 5515
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
52 SSUH2  
Affinity Capture-MS Homo sapiens
53 RPA4  
Proximity Label-MS Homo sapiens
54 DDX1 1653
Co-fractionation Homo sapiens
55 DYNLL2 140735
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 CTTNBP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 RMDN3 55177
Proximity Label-MS Homo sapiens
58 Ppp2r1a 51792
Affinity Capture-MS Mus musculus
59 YEATS4  
Affinity Capture-MS Homo sapiens
60 NCKAP5L  
Affinity Capture-MS Homo sapiens
61 TJP1 7082
Affinity Capture-Western Homo sapiens
62 STK3 6788
Proximity Label-MS Homo sapiens
63 Strn3  
Affinity Capture-MS Mus musculus
64 XPO1 7514
Affinity Capture-MS Homo sapiens
65 BAG2 9532
Affinity Capture-MS Homo sapiens
66 ECT2 1894
Affinity Capture-MS Homo sapiens
67 CCT6A 908
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
68 AHNAK 79026
Affinity Capture-MS Homo sapiens
69 TNFRSF1A 7132
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 ENDOD1 23052
Affinity Capture-MS Homo sapiens
71 CTTN 2017
Affinity Capture-MS Homo sapiens
72 CCT4 10575
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
73 HOOK3 84376
Proximity Label-MS Homo sapiens
74 TFPT  
Affinity Capture-MS Homo sapiens
75 PCOLCE2 26577
Affinity Capture-MS Homo sapiens
76 NUP214 8021
Affinity Capture-MS Homo sapiens
77 PRPF19 27339
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
78 PPP2R1A 5518
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
79 RPA3 6119
Proximity Label-MS Homo sapiens
80 RINT1 60561
Two-hybrid Homo sapiens
81 GOLGA1  
Proximity Label-MS Homo sapiens
82 PSMC5 5705
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
83 RABGAP1L 9910
Affinity Capture-MS Homo sapiens
84 FLII 2314
Affinity Capture-MS Homo sapiens
85 Dynll1 56455
Affinity Capture-MS Mus musculus
86 PCM1 5108
Affinity Capture-MS Homo sapiens
87 STK4 6789
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
88 PPP2CB 5516
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
89 KIAA1522 57648
Affinity Capture-MS Homo sapiens
90 ZRANB1 54764
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
91 EIF2S1 1965
Co-fractionation Homo sapiens
92 PMF1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
93 RASSF3 283349
Affinity Capture-MS Homo sapiens
94 STK24 8428
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
95 GIPC1 10755
Proximity Label-MS Homo sapiens
96 CCT8 10694
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
97 PLP1 5354
Affinity Capture-MS Homo sapiens
98 SLMAP 7871
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
99 CPSF6 11052
Co-fractionation Homo sapiens
100 PRDM14  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
101 MAP1S 55201
Affinity Capture-MS Homo sapiens
102 CCHCR1  
Affinity Capture-MS Homo sapiens
103 LRRCC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
104 SPINK2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
105 STRIP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
106 HSPB1 3315
Affinity Capture-MS Homo sapiens
107 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
108 CAPZB 832
Affinity Capture-MS Homo sapiens
109 STK26 51765
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
110 FILIP1  
Affinity Capture-MS Homo sapiens
111 CCT7 10574
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
112 DYNC1H1 1778
Co-fractionation Homo sapiens
113 ISCA2 122961
Affinity Capture-MS Homo sapiens
114 PSMA5 5686
Affinity Capture-MS Homo sapiens
115 FGFR1OP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
116 GOLGA5 9950
Affinity Capture-MS Homo sapiens
117 STARD10 10809
Cross-Linking-MS (XL-MS) Homo sapiens
118 NHSL2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
119 ZNF331  
Affinity Capture-MS Homo sapiens
120 LNX1  
Two-hybrid Homo sapiens
121 CUL4A 8451
Affinity Capture-MS Homo sapiens
122 PSMD3 5709
Co-fractionation Homo sapiens
View the network image/svg+xml



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