Gene description for RXRA
Gene name retinoid X receptor, alpha
Gene symbol RXRA
Other names/aliases NR2B1
Species Homo sapiens
 Database cross references - RXRA
ExoCarta ExoCarta_6256
Vesiclepedia VP_6256
Entrez Gene 6256
HGNC 10477
MIM 180245
UniProt P19793  
 RXRA identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for RXRA
Molecular Function
    transcription cis-regulatory region binding GO:0000976 IDA
    RNA polymerase II transcription regulatory region sequence-specific DNA binding GO:0000977 IDA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IDA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 ISA
    transcription coregulator binding GO:0001221 IPI
    retinoic acid binding GO:0001972 IDA
    double-stranded DNA binding GO:0003690 IMP
    DNA-binding transcription factor activity GO:0003700 IDA
    nuclear steroid receptor activity GO:0003707 IEA
    nuclear receptor activity GO:0004879 IBA
    nuclear receptor activity GO:0004879 IDA
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 IDA
    enzyme binding GO:0019899 IPI
    peptide binding GO:0042277 IDA
    identical protein binding GO:0042802 IPI
    nuclear vitamin D receptor binding GO:0042809 IPI
    sequence-specific DNA binding GO:0043565 IDA
    retinoic acid-responsive element binding GO:0044323 IBA
    retinoic acid-responsive element binding GO:0044323 IDA
    DNA binding domain binding GO:0050692 IDA
    LBD domain binding GO:0050693 IDA
    vitamin D response element binding GO:0070644 IDA
    sequence-specific double-stranded DNA binding GO:1990837 IDA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IDA
    positive regulation of thyroid hormone receptor signaling pathway GO:0002157 IDA
    nervous system development GO:0007399 IBA
    hormone-mediated signaling pathway GO:0009755 IDA
    hormone-mediated signaling pathway GO:0009755 ISS
    positive regulation of cholesterol efflux GO:0010875 TAS
    cell differentiation GO:0030154 IBA
    positive regulation of bone mineralization GO:0030501 NAS
    positive regulation of transporter activity GO:0032411 TAS
    response to retinoic acid GO:0032526 IMP
    peroxisome proliferator activated receptor signaling pathway GO:0035357 IDA
    mRNA transcription by RNA polymerase II GO:0042789 IDA
    mRNA transcription by RNA polymerase II GO:0042789 ISS
    mRNA transcription by RNA polymerase II GO:0042789 NAS
    steroid hormone receptor signaling pathway GO:0043401 IEA
    positive regulation of DNA-templated transcription GO:0045893 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 IBA
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 ISS
    positive regulation of transcription by RNA polymerase II GO:0045944 NAS
    retinoic acid receptor signaling pathway GO:0048384 IBA
    retinoic acid receptor signaling pathway GO:0048384 IDA
    retinoic acid receptor signaling pathway GO:0048384 IMP
    positive regulation of vitamin D receptor signaling pathway GO:0070564 IDA
Subcellular Localization
    chromatin GO:0000785 IDA
    chromatin GO:0000785 IDA
    chromatin GO:0000785 ISA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 TAS
    transcription regulator complex GO:0005667 IPI
    mitochondrion GO:0005739 IEA
    cytosol GO:0005829 TAS
    receptor complex GO:0043235 IDA
    RNA polymerase II transcription regulator complex GO:0090575 EXP
    RNA polymerase II transcription regulator complex GO:0090575 IBA
    RNA polymerase II transcription regulator complex GO:0090575 IDA
    RNA polymerase II transcription regulator complex GO:0090575 IPI
    RNA polymerase II transcription regulator complex GO:0090575 ISS
    RNA polymerase II transcription regulator complex GO:0090575 NAS
 Experiment description of studies that identified RXRA in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for RXRA
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ITGB1 3688
Co-fractionation Homo sapiens
2 PPARA  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
FRET Homo sapiens
3 NCOA6  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
4 HDAC4  
Reconstituted Complex Homo sapiens
5 NR2F6  
Two-hybrid Homo sapiens
6 GATSL2  
Affinity Capture-MS Homo sapiens
7 TK1 7083
Two-hybrid Homo sapiens
8 THRB 7068
Reconstituted Complex Homo sapiens
Far Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
9 TADA3  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
10 GADD45G  
Reconstituted Complex Homo sapiens
11 GADD45A  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
12 SP1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
13 Pparg  
Two-hybrid Mus musculus
Reconstituted Complex Mus musculus
14 EMD 2010
Affinity Capture-MS Homo sapiens
15 TRADD 8717
Co-fractionation Homo sapiens
16 RNMT 8731
Co-fractionation Homo sapiens
17 CALM1 801
Affinity Capture-MS Homo sapiens
18 MED24 9862
Reconstituted Complex Homo sapiens
19 RIPK1 8737
Co-fractionation Homo sapiens
20 ARNTL  
Reconstituted Complex Homo sapiens
21 MYOD1  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
22 JAZF1  
Two-hybrid Homo sapiens
23 NR1I2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
24 HDAC3 8841
Reconstituted Complex Homo sapiens
25 NCOR1  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
26 CTNNB1 1499
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-MS Homo sapiens
27 RNF8  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
FRET Homo sapiens
28 SRC 6714
Reconstituted Complex Homo sapiens
29 STAT3 6774
Co-fractionation Homo sapiens
30 NR1H3  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
31 TDG 6996
Reconstituted Complex Homo sapiens
32 NCOA3  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
33 NR1H2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
34 ARID5A  
Two-hybrid Homo sapiens
35 NSD1  
Two-hybrid Homo sapiens
36 VDR  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Co-crystal Structure Homo sapiens
Affinity Capture-Western Homo sapiens
37 NR2E3  
Reconstituted Complex Homo sapiens
38 GATSL3 652968
Affinity Capture-MS Homo sapiens
39 UBQLN4 56893
Two-hybrid Homo sapiens
40 FGFR1 2260
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
41 CTCF  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
42 NCOA1  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Far Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
43 MED1 5469
Two-hybrid Homo sapiens
Co-localization Homo sapiens
Reconstituted Complex Homo sapiens
44 MAPK1 5594
Biochemical Activity Homo sapiens
45 CLOCK  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
46 ITGB3BP  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
47 MAPK3 5595
Biochemical Activity Homo sapiens
48 PPP5C 5536
Co-fractionation Homo sapiens
49 CAPZA1 829
Affinity Capture-MS Homo sapiens
50 IGFBP3 3486
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
51 ZBTB16  
Co-localization Homo sapiens
52 NCOR2  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
53 LRRFIP2 9209
Affinity Capture-MS Homo sapiens
54 NONO 4841
Affinity Capture-MS Homo sapiens
55 TRIM24  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
56 CSNK2B 1460
Two-hybrid Homo sapiens
57 UBE2I 7329
Biochemical Activity Homo sapiens
58 SMARCA4 6597
Affinity Capture-Western Homo sapiens
59 ACVR1B 91
Two-hybrid Homo sapiens
60 CNOT1 23019
Two-hybrid Homo sapiens
61 MYH9 4627
Affinity Capture-MS Homo sapiens
62 PPARD  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
FRET Homo sapiens
63 PLK1 5347
Two-hybrid Homo sapiens
64 GK  
Two-hybrid Homo sapiens
65 TRIM32 22954
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
66 SMAD2 4087
Two-hybrid Homo sapiens
67 PML 5371
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
68 PIK3R1 5295
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
69 RAD54L2  
Reconstituted Complex Homo sapiens
70 DNTTIP2  
Reconstituted Complex Homo sapiens
71 NR1I3  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
72 RPS6KA6 27330
Two-hybrid Homo sapiens
73 Parp1  
Reconstituted Complex Rattus norvegicus
74 Gadd45b  
Reconstituted Complex Mus musculus
75 NR4A1  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Phenotypic Enhancement Homo sapiens
76 MCCC2 64087
Co-fractionation Homo sapiens
77 LMNB1 4001
Affinity Capture-MS Homo sapiens
78 DNMT3L  
Reconstituted Complex Homo sapiens
79 NR0B2  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
80 PPARG 5468
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Affinity Capture-Western Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Co-crystal Structure Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Proximity Label-MS Homo sapiens
Co-purification Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
FRET Homo sapiens
81 TMPRSS3  
Two-hybrid Homo sapiens
82 TAF1B  
Reconstituted Complex Homo sapiens
83 BRD8 10902
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
84 TRAF6 7189
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
85 CASP2  
Two-hybrid Homo sapiens
86 NRBF2  
Two-hybrid Homo sapiens
87 RARB  
Co-crystal Structure Homo sapiens
88 BHLHE40  
Affinity Capture-Western Homo sapiens
89 BCL3  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
90 FUS 2521
Reconstituted Complex Homo sapiens
91 POLR2A 5430
Co-localization Homo sapiens
92 NPAS2  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
93 BHLHE41  
Affinity Capture-Western Homo sapiens
94 THRA  
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
95 TBP  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
96 STAT1 6772
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
97 XRCC6 2547
Affinity Capture-MS Homo sapiens
98 Ncoa2  
Reconstituted Complex Mus musculus
99 ROBO4  
Reconstituted Complex Homo sapiens
100 ZDHHC18 84243
Affinity Capture-MS Homo sapiens
101 ITGB4 3691
Co-fractionation Homo sapiens
102 RXRG  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
103 NFKB1 4790
Reconstituted Complex Homo sapiens
104 PSMC5 5705
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
105 MED23 9439
Co-fractionation Homo sapiens
106 MATR3 9782
Affinity Capture-MS Homo sapiens
107 SMN1 6606
Two-hybrid Homo sapiens
108 EDF1 8721
Reconstituted Complex Homo sapiens
109 POU2F2 5452
Reconstituted Complex Homo sapiens
110 GRIP1  
Reconstituted Complex Homo sapiens
111 MED25  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
112 RARG  
Two-hybrid Homo sapiens
113 TPM3 7170
Affinity Capture-MS Homo sapiens
114 PRKD2 25865
Two-hybrid Homo sapiens
115 RELA 5970
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
Reconstituted Complex Homo sapiens
116 KIF1A 547
Two-hybrid Homo sapiens
117 GSK3B 2932
Two-hybrid Homo sapiens
118 RARA 5914
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Co-crystal Structure Homo sapiens
Far Western Homo sapiens
Two-hybrid Homo sapiens
Co-localization Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
119 TRAF2 7186
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
120 CTSL 1514
Biochemical Activity Homo sapiens
121 NR4A2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
122 NT5DC3 51559
Co-fractionation Homo sapiens
123 ALOX15B  
Two-hybrid Homo sapiens
124 NCOA2 10499
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
125 NR3C2  
Two-hybrid Homo sapiens
126 SQSTM1 8878
Affinity Capture-MS Homo sapiens
127 ZDHHC23  
Affinity Capture-MS Homo sapiens
128 MEF2D  
Co-fractionation Homo sapiens
129 POU2F1 5451
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
130 NR1H4  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
131 ESR1  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
132 KLF5  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
133 MIOS 54468
Affinity Capture-MS Homo sapiens
134 REPS1 85021
Affinity Capture-MS Homo sapiens
135 TRIP4 9325
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
136 RXRA 6256
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
137 MIPEP  
Co-fractionation Homo sapiens
138 NRIP1 8204
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
139 SNW1 22938
Reconstituted Complex Homo sapiens
140 KRAS 3845
Negative Genetic Homo sapiens
141 NFKBIB  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
142 SMARCD3  
Reconstituted Complex Homo sapiens
143 PPARGC1A  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
144 NCOA4 8031
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
145 EP300 2033
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which RXRA is involved
PathwayEvidenceSource
Activation of anterior HOX genes in hindbrain development during early embryogenesis IEA Reactome
Activation of gene expression by SREBF (SREBP) TAS Reactome
Activation of HOX genes during differentiation IEA Reactome
Adipogenesis TAS Reactome
Adipogenesis IEA Reactome
Bile acid and bile salt metabolism TAS Reactome
Biological oxidations TAS Reactome
BMAL1:CLOCK,NPAS2 activates circadian gene expression IEA Reactome
Carnitine shuttle TAS Reactome
Cellular response to chemical stress TAS Reactome
Cellular responses to stimuli IEA Reactome
Cellular responses to stimuli TAS Reactome
Cellular responses to stress IEA Reactome
Cellular responses to stress TAS Reactome
Circadian Clock IEA Reactome
Cytochrome P450 - arranged by substrate type TAS Reactome
Cytoprotection by HMOX1 TAS Reactome
Developmental Biology TAS Reactome
Developmental Biology IEA Reactome
Endogenous sterols TAS Reactome
Epigenetic regulation by WDR5-containing histone modifying complexes IEA Reactome
Epigenetic regulation by WDR5-containing histone modifying complexes TAS Reactome
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes IEA Reactome
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes TAS Reactome
Epigenetic regulation of gene expression IEA Reactome
Epigenetic regulation of gene expression TAS Reactome
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes IEA Reactome
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes TAS Reactome
Fatty acid metabolism TAS Reactome
Gene expression (Transcription) TAS Reactome
Gene expression (Transcription) IEA Reactome
Generic Transcription Pathway TAS Reactome
Heme signaling IEA Reactome
Metabolism TAS Reactome
Metabolism IEA Reactome
Metabolism of lipids TAS Reactome
Metabolism of lipids IEA Reactome
Metabolism of proteins TAS Reactome
Metabolism of steroids TAS Reactome
Mitochondrial biogenesis TAS Reactome
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis IEA Reactome
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis TAS Reactome
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis TAS Reactome
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis TAS Reactome
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose TAS Reactome
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis TAS Reactome
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake TAS Reactome
NR1H2 and NR1H3-mediated signaling TAS Reactome
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux TAS Reactome
Nuclear Receptor transcription pathway TAS Reactome
Organelle biogenesis and maintenance TAS Reactome
Phase I - Functionalization of compounds TAS Reactome
Post-translational protein modification TAS Reactome
PPARA activates gene expression TAS Reactome
PPARA activates gene expression IEA Reactome
Recycling of bile acids and salts TAS Reactome
Regulation of cholesterol biosynthesis by SREBP (SREBF) TAS Reactome
Regulation of lipid metabolism by PPARalpha TAS Reactome
Regulation of lipid metabolism by PPARalpha IEA Reactome
RNA Polymerase II Transcription TAS Reactome
RORA activates gene expression IEA Reactome
Signal Transduction TAS Reactome
Signaling by Nuclear Receptors TAS Reactome
Signaling by Retinoic Acid TAS Reactome
Signaling by TGFB family members TAS Reactome
Signaling by TGFBR3 TAS Reactome
SUMO E3 ligases SUMOylate target proteins TAS Reactome
SUMOylation TAS Reactome
SUMOylation of intracellular receptors TAS Reactome
Synthesis of bile acids and bile salts TAS Reactome
Synthesis of bile acids and bile salts via 27-hydroxycholesterol TAS Reactome
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol TAS Reactome
TGFBR3 expression TAS Reactome
Transcriptional activation of mitochondrial biogenesis TAS Reactome
Transcriptional regulation of brown and beige adipocyte differentiation IEA Reactome
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 IEA Reactome
Transcriptional regulation of granulopoiesis IEA Reactome
Transcriptional regulation of granulopoiesis TAS Reactome
Transcriptional regulation of white adipocyte differentiation TAS Reactome
Transcriptional regulation of white adipocyte differentiation IEA Reactome





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