Gene description for RARA
Gene name	retinoic acid receptor, alpha
Gene symbol	RARA
Other names/aliases	NR1B1 RAR
Species	Homo sapiens
Database cross references - RARA
ExoCarta	ExoCarta_5914
Vesiclepedia	VP_5914
Entrez Gene	5914
HGNC	9864
MIM	180240
UniProt	P10276
RARA identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells	25944692

Gene ontology annotations for RARA

Molecular Function     mRNA regulatory element binding translation repressor activity GO:0000900 IEA     RNA polymerase II transcription regulatory region sequence-specific DNA binding GO:0000977 IDA     RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA     RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IDA     RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IMP     DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 ISA     DNA-binding transcription repressor activity GO:0001217 IMP     transcription coactivator binding GO:0001223 IPI     retinoic acid binding GO:0001972 IDA     chromatin binding GO:0003682 IDA     DNA-binding transcription factor activity GO:0003700 IDA     nuclear receptor activity GO:0004879 IBA     nuclear receptor activity GO:0004879 IDA     signaling receptor binding GO:0005102 IDA     protein binding GO:0005515 IPI     zinc ion binding GO:0008270 IEA     enzyme binding GO:0019899 IPI     protein domain specific binding GO:0019904 IPI     chromatin DNA binding GO:0031490 IDA     histone deacetylase binding GO:0042826 IEA     protein kinase B binding GO:0043422 IPI     retinoic acid-responsive element binding GO:0044323 IDA     mRNA 5'-UTR binding GO:0048027 IEA     protein kinase A binding GO:0051018 IDA     alpha-actinin binding GO:0051393 IPI     heterocyclic compound binding GO:1901363 IEA     sequence-specific double-stranded DNA binding GO:1990837 IDA Biological Process     negative regulation of transcription by RNA polymerase II GO:0000122 IBA     ureteric bud development GO:0001657 IEA     neural tube closure GO:0001843 IEA     liver development GO:0001889 IEA     glandular epithelial cell development GO:0002068 IEA     outflow tract septum morphogenesis GO:0003148 IEA     growth plate cartilage development GO:0003417 IEA     protein phosphorylation GO:0006468 IMP     germ cell development GO:0007281 IEA     spermatogenesis GO:0007283 IEA     female pregnancy GO:0007565 IEA     positive regulation of cell population proliferation GO:0008284 IMP     negative regulation of cell population proliferation GO:0008285 IEA     negative regulation of translation GO:0017148 IEA     hippocampus development GO:0021766 IEA     cell differentiation GO:0030154 IBA     prostate gland development GO:0030850 IEA     negative regulation of granulocyte differentiation GO:0030853 IDA     embryonic camera-type eye development GO:0031076 IEA     regulation of myelination GO:0031641 IEA     response to estradiol GO:0032355 IEA     response to retinoic acid GO:0032526 IMP     negative regulation of type II interferon production GO:0032689 IDA     negative regulation of tumor necrosis factor production GO:0032720 IDA     positive regulation of interleukin-13 production GO:0032736 IDA     positive regulation of interleukin-4 production GO:0032753 IDA     positive regulation of interleukin-5 production GO:0032754 IDA     response to vitamin A GO:0033189 IEA     response to cytokine GO:0034097 IEA     multicellular organism growth GO:0035264 IEA     mRNA transcription by RNA polymerase II GO:0042789 IDA     mRNA transcription by RNA polymerase II GO:0042789 NAS     negative regulation of apoptotic process GO:0043066 IEA     apoptotic cell clearance GO:0043277 IMP     response to ethanol GO:0045471 IEA     positive regulation of T-helper 2 cell differentiation GO:0045630 IDA     positive regulation of neuron differentiation GO:0045666 IEA     positive regulation of cell cycle GO:0045787 IMP     negative regulation of DNA-templated transcription GO:0045892 IDA     positive regulation of DNA-templated transcription GO:0045893 IDA     positive regulation of DNA-templated transcription GO:0045893 IMP     positive regulation of transcription by RNA polymerase II GO:0045944 IBA     positive regulation of transcription by RNA polymerase II GO:0045944 IDA     positive regulation of transcription by RNA polymerase II GO:0045944 IMP     positive regulation of transcription by RNA polymerase II GO:0045944 ISS     regulation of synaptic plasticity GO:0048167 IEA     retinoic acid receptor signaling pathway GO:0048384 IBA     retinoic acid receptor signaling pathway GO:0048384 IDA     retinoic acid receptor signaling pathway GO:0048384 IMP     positive regulation of binding GO:0051099 IMP     ventricular cardiac muscle cell differentiation GO:0055012 IEA     Sertoli cell fate commitment GO:0060010 IEA     limb development GO:0060173 IEA     face development GO:0060324 IEA     trachea cartilage development GO:0060534 IEA     chondroblast differentiation GO:0060591 IEA     negative regulation of cartilage development GO:0061037 IEA     cellular response to lipopolysaccharide GO:0071222 IEA     cellular response to retinoic acid GO:0071300 IMP     cellular response to estrogen stimulus GO:0071391 IDA     regulation of hematopoietic progenitor cell differentiation GO:1901532 IEA     negative regulation of miRNA transcription GO:1902894 IMP Subcellular Localization     chromatin GO:0000785 IDA     chromatin GO:0000785 IDA     chromatin GO:0000785 ISA     nucleus GO:0005634 IBA     nucleus GO:0005634 IDA     nucleoplasm GO:0005654 IDA     nucleoplasm GO:0005654 TAS     transcription regulator complex GO:0005667 IPI     nucleolus GO:0005730 IDA     cytoplasm GO:0005737 IDA     cytosol GO:0005829 IDA     plasma membrane GO:0005886 IDA     actin cytoskeleton GO:0015629 IDA     dendrite GO:0030425 IEA     protein-containing complex GO:0032991 IDA     perinuclear region of cytoplasm GO:0048471 IEA     RNA polymerase II transcription regulator complex GO:0090575 IDA     RNA polymerase II transcription regulator complex GO:0090575 NAS