Gene description for FBXO7
Gene name F-box protein 7
Gene symbol FBXO7
Other names/aliases FBX
FBX07
FBX7
PARK15
PKPS
Species Homo sapiens
 Database cross references - FBXO7
ExoCarta ExoCarta_25793
Vesiclepedia VP_25793
Entrez Gene 25793
HGNC 13586
MIM 605648
UniProt Q9Y3I1  
 FBXO7 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for FBXO7
Molecular Function
    ubiquitin-protein transferase activity GO:0004842 TAS
    protein binding GO:0005515 IPI
    protein kinase binding GO:0019901 IBA
    protein kinase binding GO:0019901 IPI
    ubiquitin protein ligase binding GO:0031625 IPI
    ubiquitin binding GO:0043130 IDA
    protein heterodimerization activity GO:0046982 IPI
    ubiquitin-like ligase-substrate adaptor activity GO:1990756 IDA
Biological Process
    autophagy of mitochondrion GO:0000422 IMP
    ubiquitin-dependent protein catabolic process GO:0006511 IDA
    protein targeting to mitochondrion GO:0006626 IMP
    regulation of neuron projection development GO:0010975 IMP
    protein ubiquitination GO:0016567 IDA
    protein ubiquitination GO:0016567 IMP
    lymphocyte differentiation GO:0030098 IEA
    regulation of protein stability GO:0031647 IDA
    regulation of locomotion GO:0040012 IDA
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IDA
    negative regulation of lymphocyte differentiation GO:0045620 IEA
    protein K48-linked ubiquitination GO:0070936 IDA
    positive regulation of mitophagy GO:1901526 IDA
    negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway GO:1903377 IDA
    negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway GO:1903377 IMP
    positive regulation of autophagy of mitochondrion GO:1903599 IBA
    negative regulation of G1/S transition of mitotic cell cycle GO:2000134 IEA
Subcellular Localization
    ubiquitin ligase complex GO:0000151 IDA
    nucleus GO:0005634 IDA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IDA
    mitochondrion GO:0005739 IDA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    SCF ubiquitin ligase complex GO:0019005 IDA
    SCF ubiquitin ligase complex GO:0019005 TAS
    protein-containing complex GO:0032991 IDA
    glial cytoplasmic inclusion GO:0097409 IDA
    classical Lewy body GO:0097414 IDA
    Lewy neurite GO:0097462 IDA
    Lewy body core GO:1990037 IDA
    Lewy body corona GO:1990038 IDA
 Experiment description of studies that identified FBXO7 in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for FBXO7
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PSMA6 5687
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 PSME2 5721
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 CDC34 997
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
4 RAP1GAP 5909
Affinity Capture-MS Homo sapiens
5 Cul1 26965
Affinity Capture-MS Mus musculus
6 NPRL2  
Affinity Capture-MS Homo sapiens
7 TCEB1 6921
Affinity Capture-MS Homo sapiens
8 COPS8 10920
Affinity Capture-MS Homo sapiens
9 Psmb5 19173
Affinity Capture-MS Mus musculus
10 CIB2  
Affinity Capture-MS Homo sapiens
11 HOXA7  
Affinity Capture-MS Homo sapiens
12 Skp1a 21402
Affinity Capture-MS Mus musculus
13 ESF1 51575
Affinity Capture-MS Homo sapiens
14 CBWD2  
Affinity Capture-MS Homo sapiens
15 UBC 7316
Affinity Capture-MS Homo sapiens
16 EYA2  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
17 CAND1 55832
Affinity Capture-MS Homo sapiens
18 ANKRD39  
Affinity Capture-MS Homo sapiens
19 SIX1  
Affinity Capture-Western Homo sapiens
20 SOX9  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
21 CCDC102B  
Affinity Capture-MS Homo sapiens
22 CELA3A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 PVRL3 25945
Affinity Capture-MS Homo sapiens
24 SBF2 81846
Affinity Capture-MS Homo sapiens
25 PSMC5 5705
Co-fractionation Homo sapiens
26 CRNKL1 51340
Affinity Capture-MS Homo sapiens
27 COPS6 10980
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 RFXANK  
Affinity Capture-MS Homo sapiens
29 SHMT2 6472
Affinity Capture-MS Homo sapiens
30 HOXB8  
Affinity Capture-MS Homo sapiens
31 SEC24C 9632
Two-hybrid Homo sapiens
32 COPS5 10987
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 BRCC3 79184
Co-fractionation Homo sapiens
34 AGO3  
Affinity Capture-MS Homo sapiens
35 PSMB6 5694
Affinity Capture-MS Homo sapiens
36 TTC38 55020
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 STIP1 10963
Affinity Capture-MS Homo sapiens
38 C3orf52  
Affinity Capture-MS Homo sapiens
39 MED22  
Affinity Capture-MS Homo sapiens
40 PDIA6 10130
Affinity Capture-MS Homo sapiens
41 ATG7 10533
Affinity Capture-MS Homo sapiens
42 PSMB9 5698
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 ESPL1  
Affinity Capture-MS Homo sapiens
44 NSFL1C 55968
Affinity Capture-MS Homo sapiens
45 CUL1 8454
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
46 GPS1 2873
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 NPAS1  
Affinity Capture-MS Homo sapiens
48 YAF2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 PSMB3 5691
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 METTL10  
Affinity Capture-MS Homo sapiens
51 PSME3 10197
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
52 TSHR 7253
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 ZBTB48  
Affinity Capture-MS Homo sapiens
54 PSMB4 5692
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 RBX1 9978
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 PARK2  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
57 PSME1 5720
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 SKAP2 8935
Affinity Capture-MS Homo sapiens
59 PSMG2 56984
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 NT5C 30833
Affinity Capture-MS Homo sapiens
61 PPARD  
Affinity Capture-MS Homo sapiens
62 XPOT 11260
Affinity Capture-MS Homo sapiens
63 TRIM11  
Affinity Capture-MS Homo sapiens
64 TTC9C 283237
Affinity Capture-MS Homo sapiens
65 PARP10 84875
Affinity Capture-MS Homo sapiens
66 COPS3 8533
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 UBE2D3 7323
Reconstituted Complex Homo sapiens
68 COPS7B 64708
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 VCPIP1 80124
Affinity Capture-MS Homo sapiens
70 HINT3 135114
Affinity Capture-MS Homo sapiens
71 UBXN6 80700
Affinity Capture-MS Homo sapiens
72 NMNAT2  
Affinity Capture-MS Homo sapiens
73 MAT2A 4144
Co-fractionation Homo sapiens
74 DUSP22  
Affinity Capture-MS Homo sapiens
75 BIRC2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
76 RBBP6 5930
Two-hybrid Homo sapiens
77 RNF40 9810
Co-fractionation Homo sapiens
78 PSMA3 5684
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
79 COPS2 9318
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 COPS7A 50813
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
81 RNF181  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
82 XPO1 7514
Reconstituted Complex Homo sapiens
83 PANX1 24145
Affinity Capture-MS Homo sapiens
84 BAG2 9532
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
85 ZNF252P-AS1  
Affinity Capture-MS Homo sapiens
86 LOXL2 4017
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
87 PSMF1 9491
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
88 PSMA2 5683
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
89 GBF1 8729
Affinity Capture-MS Homo sapiens
90 METTL21B  
Affinity Capture-MS Homo sapiens
91 HNRNPCL2 440563
Affinity Capture-MS Homo sapiens
92 UBE2D2 7322
Biochemical Activity Homo sapiens
93 DNAI2  
Affinity Capture-MS Homo sapiens
94 SELENBP1 8991
Affinity Capture-MS Homo sapiens
95 NFKB1 4790
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
96 HPSE 10855
Affinity Capture-MS Homo sapiens
97 PSMB5 5693
Co-fractionation Homo sapiens
98 LGI1  
Affinity Capture-MS Homo sapiens
99 HSPD1 3329
Affinity Capture-MS Homo sapiens
100 DLGAP5  
Affinity Capture-Western Homo sapiens
101 FOXO4  
Affinity Capture-Western Homo sapiens
102 PSMB1 5689
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
103 PDE3A  
Affinity Capture-MS Homo sapiens
104 FLOT1 10211
Affinity Capture-MS Homo sapiens
105 TOMM20 9804
Reconstituted Complex Homo sapiens
106 PSMB2 5690
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
107 CLPP 8192
Proximity Label-MS Homo sapiens
108 FBXW2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
109 PRKCSH 5589
Affinity Capture-MS Homo sapiens
110 TRAF2 7186
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
111 PRKY  
Affinity Capture-MS Homo sapiens
112 Psmb4 19172
Affinity Capture-MS Mus musculus
113 PSMB7 5695
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
114 SAP18 10284
Affinity Capture-MS Homo sapiens
115 EDEM1  
Affinity Capture-MS Homo sapiens
116 SKP1 6500
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
117 SHFM1 7979
Affinity Capture-MS Homo sapiens
118 PRMT1 3276
Affinity Capture-MS Homo sapiens
119 TKT 7086
Affinity Capture-MS Homo sapiens
120 CDK6 1021
Affinity Capture-Western Homo sapiens
121 SIRT1  
Affinity Capture-MS Homo sapiens
122 AARSD1 80755
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
123 EXD2  
Proximity Label-MS Homo sapiens
124 C6orf141  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
125 RBFOX2 23543
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
126 MAGED1 9500
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
127 PSMA5 5686
Affinity Capture-MS Homo sapiens
128 INF2 64423
Affinity Capture-MS Homo sapiens
129 PINK1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
130 SSSCA1 10534
Affinity Capture-MS Homo sapiens
131 OLFM2  
Affinity Capture-MS Homo sapiens
132 PEX5 5830
Affinity Capture-MS Homo sapiens
133 C9orf72  
Affinity Capture-MS Homo sapiens
134 COPS4 51138
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
135 CCT8L2  
Affinity Capture-MS Homo sapiens
136 RPA3 6119
Proximity Label-MS Homo sapiens
137 BCAT1 586
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
138 SRRT 51593
Affinity Capture-MS Homo sapiens
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