Gene description for GSPT1
Gene name G1 to S phase transition 1
Gene symbol GSPT1
Other names/aliases 551G9.2
Species Homo sapiens
 Database cross references - GSPT1
ExoCarta ExoCarta_2935
Entrez Gene 2935
HGNC 4621
MIM 139259
UniProt P15170  
 GSPT1 identified in exosomes derived from the following tissue/cell type
Squamous carcinoma cells 20124223    
 Gene ontology annotations for GSPT1
Molecular Function
    translation release factor activity GO:0003747 IMP
    poly(A) RNA binding GO:0044822 IDA
    GTPase activity GO:0003924 TAS
    protein binding GO:0005515 IPI
    GTP binding GO:0005525 IEA
Biological Process
    translational termination GO:0006415 IMP
    nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 TAS
    G1/S transition of mitotic cell cycle GO:0000082 TAS
    protein methylation GO:0006479 IDA
Subcellular Localization
    intracellular GO:0005622 NAS
 Experiment description of studies that identified GSPT1 in exosomes
Experiment ID 191
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK.
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for GSPT1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 XIAP  
Affinity Capture-Western Homo sapiens
2 BIRC2  
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
3 ETF1 2107
Invivo Homo sapiens
Two-hybrid Homo sapiens
4 PABPC1 26986
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which GSPT1 is involved
No pathways found

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