Gene description for TRAF2
Gene name TNF receptor-associated factor 2
Gene symbol TRAF2
Other names/aliases MGC:45012
TRAP
TRAP3
Species Homo sapiens
 Database cross references - TRAF2
ExoCarta ExoCarta_7186
Vesiclepedia VP_7186
Entrez Gene 7186
HGNC 12032
MIM 601895
UniProt Q12933  
 TRAF2 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for TRAF2
Molecular Function
    ubiquitin-protein transferase activity GO:0004842 EXP
    ubiquitin-protein transferase activity GO:0004842 IBA
    ubiquitin-protein transferase activity GO:0004842 IDA
    tumor necrosis factor receptor binding GO:0005164 IBA
    tumor necrosis factor receptor binding GO:0005164 IPI
    CD40 receptor binding GO:0005174 ISS
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 IEA
    enzyme binding GO:0019899 IPI
    protein kinase binding GO:0019901 IPI
    protein phosphatase binding GO:0019903 IPI
    protein-macromolecule adaptor activity GO:0030674 IDA
    protein-macromolecule adaptor activity GO:0030674 IPI
    mitogen-activated protein kinase kinase kinase binding GO:0031435 IEA
    ubiquitin protein ligase binding GO:0031625 IDA
    ubiquitin protein ligase binding GO:0031625 IPI
    thioesterase binding GO:0031996 IPI
    signaling adaptor activity GO:0035591 IBA
    identical protein binding GO:0042802 IPI
    tumor necrosis factor binding GO:0043120 IPI
    protein-containing complex binding GO:0044877 IEA
    sphingolipid binding GO:0046625 IDA
    ubiquitin protein ligase activity GO:0061630 IDA
Biological Process
    regulation of immunoglobulin production GO:0002637 IEA
    positive regulation of T cell cytokine production GO:0002726 IMP
    signal transduction GO:0007165 TAS
    signal transduction involved in regulation of gene expression GO:0023019 IEA
    CD40 signaling pathway GO:0023035 IDA
    protein catabolic process GO:0030163 IEA
    positive regulation of interleukin-2 production GO:0032743 IMP
    tumor necrosis factor-mediated signaling pathway GO:0033209 IBA
    tumor necrosis factor-mediated signaling pathway GO:0033209 IDA
    negative regulation of glial cell apoptotic process GO:0034351 IEA
    response to endoplasmic reticulum stress GO:0034976 NAS
    non-canonical NF-kappaB signal transduction GO:0038061 IDA
    T cell activation GO:0042110 IDA
    regulation of apoptotic process GO:0042981 IDA
    positive regulation of canonical NF-kappaB signal transduction GO:0043123 IBA
    positive regulation of canonical NF-kappaB signal transduction GO:0043123 IMP
    regulation of protein-containing complex assembly GO:0043254 IMP
    positive regulation of JUN kinase activity GO:0043507 IDA
    innate immune response GO:0045087 IDA
    regulation of JNK cascade GO:0046328 IEA
    mRNA stabilization GO:0048255 IEA
    positive regulation of DNA-binding transcription factor activity GO:0051091 IMP
    positive regulation of NF-kappaB transcription factor activity GO:0051092 IDA
    positive regulation of NF-kappaB transcription factor activity GO:0051092 IMP
    protein autoubiquitination GO:0051865 IDA
    protein autoubiquitination GO:0051865 TAS
    protein-containing complex assembly GO:0065003 ISS
    intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070059 TAS
    protein K63-linked ubiquitination GO:0070534 IDA
    cellular response to nitric oxide GO:0071732 IEA
    programmed necrotic cell death GO:0097300 IEA
    interleukin-17-mediated signaling pathway GO:0097400 IEA
    CD27 signaling pathway GO:0160162 IDA
    positive regulation of tumor necrosis factor-mediated signaling pathway GO:1903265 IEA
    TORC1 complex assembly GO:1905669 IDA
    TORC2 complex disassembly GO:1905670 IDA
    positive regulation of extrinsic apoptotic signaling pathway GO:2001238 IMP
Subcellular Localization
    ubiquitin ligase complex GO:0000151 IPI
    tumor necrosis factor receptor superfamily complex GO:0002947 IDA
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    cell cortex GO:0005938 IEA
    cytoplasmic side of plasma membrane GO:0009898 IC
    cytoplasmic side of plasma membrane GO:0009898 ISS
    vesicle membrane GO:0012506 IEA
    CD40 receptor complex GO:0035631 ISS
    membrane raft GO:0045121 IEA
    TRAF2-GSTP1 complex GO:0097057 IDA
    plasma membrane signaling receptor complex GO:0098802 IBA
    IRE1-TRAF2-ASK1 complex GO:1990604 IDA
 Experiment description of studies that identified TRAF2 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for TRAF2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GSTZ1 2954
Two-hybrid Homo sapiens
2 ISG15 9636
Affinity Capture-MS Homo sapiens
3 C14orf105  
Two-hybrid Homo sapiens
4 FDXACB1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
5 HOXA7  
Affinity Capture-MS Homo sapiens
6 SAMD11  
Two-hybrid Homo sapiens
7 AES 166
Two-hybrid Homo sapiens
8 TSHZ2  
Two-hybrid Homo sapiens
9 DNAJB2 3300
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 MTMR14 64419
Affinity Capture-MS Homo sapiens
11 IP6K3  
Two-hybrid Homo sapiens
12 UBC 7316
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
13 ZNF774  
Two-hybrid Homo sapiens
14 RIPK1 8737
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
15 CD40LG 959
Affinity Capture-Western Homo sapiens
16 APEX1 328
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
17 RIPK3 11035
Affinity Capture-Western Homo sapiens
18 MAP3K5 4217
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
19 PPL 5493
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
20 RHEB 6009
Affinity Capture-Western Homo sapiens
21 SMG9 56006
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
22 MPP3  
Two-hybrid Homo sapiens
23 AFF4 27125
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
24 UBE2O 63893
Affinity Capture-Western Homo sapiens
25 AP2A1 160
Co-fractionation Homo sapiens
26 DUSP14 11072
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
27 Tnfrsf12a  
Two-hybrid Mus musculus
28 BRCC3 79184
Co-fractionation Homo sapiens
29 ZMYND11 10771
Affinity Capture-Western Homo sapiens
30 CHMP2B 25978
Two-hybrid Homo sapiens
31 NFATC2IP  
Affinity Capture-Western Homo sapiens
32 TNFRSF13B  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
33 RIPK2  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
34 PRKAB2 5565
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
35 NUDT16L1 84309
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
36 RCOR3  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
37 RAD23A 5886
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
38 MSRB2  
Two-hybrid Homo sapiens
39 TNFRSF4  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
40 ACTG1 71
Co-localization Homo sapiens
41 NFKBID  
Two-hybrid Homo sapiens
42 RABGEF1 27342
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 AMOTL2 51421
Two-hybrid Homo sapiens
44 NEDD9 4739
Two-hybrid Homo sapiens
45 TSGA10IP  
Two-hybrid Homo sapiens
46 BEX2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
47 CRY1  
Two-hybrid Homo sapiens
48 WASF1 8936
Two-hybrid Homo sapiens
49 TNFRSF14  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
50 NUDT18  
Two-hybrid Homo sapiens
51 SNRNP25  
Two-hybrid Homo sapiens
52 MAPRE1 22919
Two-hybrid Homo sapiens
53 FAM19A3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 RRAS2 22800
Two-hybrid Homo sapiens
55 RFX3 5991
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
56 DTNB 1838
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
57 GORASP2 26003
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
58 BOD1L2  
Two-hybrid Homo sapiens
59 IQUB  
Two-hybrid Homo sapiens
60 NOXA1  
Two-hybrid Homo sapiens
61 PRPF18  
Two-hybrid Homo sapiens
62 MAPK8 5599
Affinity Capture-Western Homo sapiens
63 GSG1  
Two-hybrid Homo sapiens
64 ZBTB43  
Two-hybrid Homo sapiens
65 TNFRSF10A 8797
Affinity Capture-Western Homo sapiens
66 NRF1 4899
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
67 ATXN1 6310
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
68 BIRC2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Co-localization Homo sapiens
Biochemical Activity Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
69 RNF40 9810
Co-fractionation Homo sapiens
70 ADAMTS4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 HTRA2 27429
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 SPHK1 8877
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
73 BYSL 705
Two-hybrid Homo sapiens
74 CDCA3 83461
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
75 LMP1 3783750
Affinity Capture-Western
Reconstituted Complex
Co-crystal Structure
76 PRKAR1A 5573
Co-fractionation Homo sapiens
77 CXCL3  
Affinity Capture-MS Homo sapiens
78 TNFRSF1A 7132
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
79 RBM41  
Two-hybrid Homo sapiens
80 CUL3 8452
Affinity Capture-MS Homo sapiens
81 ZNF250  
Two-hybrid Homo sapiens
82 EPRS 2058
Co-fractionation Homo sapiens
83 C16orf92  
Affinity Capture-MS Homo sapiens
84 Ern2  
Two-hybrid Mus musculus
Affinity Capture-Western Mus musculus
85 FADD 8772
Affinity Capture-Western Homo sapiens
86 CDC42 998
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
87 TMEM173  
Affinity Capture-Western Homo sapiens
88 FAM120B 84498
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
89 CASP12 100506742
Affinity Capture-Western Homo sapiens
90 EDA2R  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
91 LYSMD1  
Two-hybrid Homo sapiens
92 PKN1 5585
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
93 ZNF410  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
94 TRAF5  
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
95 RGS14  
Two-hybrid Homo sapiens
96 Tnfrsf4  
Co-crystal Structure Mus musculus
97 ITPK1 3705
Two-hybrid Homo sapiens
98 SUMO1P1  
Two-hybrid Homo sapiens
99 APEX2  
Two-hybrid Homo sapiens
100 TCEANC  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
101 CDKN1B 1027
Two-hybrid Homo sapiens
Co-localization Homo sapiens
102 UBXN2B  
Affinity Capture-MS Homo sapiens
103 FAM133A 286499
Affinity Capture-MS Homo sapiens
104 STUB1 10273
Affinity Capture-Western Homo sapiens
105 Tnfrsf8  
Two-hybrid Rattus norvegicus
106 TANK 10010
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Protein-peptide Homo sapiens
Affinity Capture-MS Homo sapiens
107 TNFRSF25  
Affinity Capture-Western Homo sapiens
108 LNX2  
Two-hybrid Homo sapiens
109 HENMT1  
Two-hybrid Homo sapiens
110 ATXN7  
Two-hybrid Homo sapiens
111 TNFSF14  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
112 CDC37 11140
Two-hybrid Homo sapiens
113 TRUB1 142940
Affinity Capture-MS Homo sapiens
114 PTPN2 5771
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
115 CWF19L2  
Two-hybrid Homo sapiens
116 HSP90AA1 3320
Co-fractionation Homo sapiens
117 CREB5 9586
Two-hybrid Homo sapiens
118 TBK1 29110
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
119 POLR3C 10623
Two-hybrid Homo sapiens
120 PSMA5 5686
Co-fractionation Homo sapiens
121 ZNF205 7755
Two-hybrid Homo sapiens
122 AIMP2 7965
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
123 NRIP1 8204
Two-hybrid Homo sapiens
124 NHSL2  
Two-hybrid Homo sapiens
125 SMURF2 64750
Affinity Capture-Western Homo sapiens
126 TRPC4AP  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
127 TRAF1 7185
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
FRET Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Co-localization Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
128 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
Affinity Capture-MS Homo sapiens
129 GSTP1 2950
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
130 ABLIM1 3983
Two-hybrid Homo sapiens
131 LYG2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
132 ERN1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
133 FBXO7 25793
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
134 SIAH2 6478
Reconstituted Complex Homo sapiens
135 SCNM1  
Two-hybrid Homo sapiens
136 HSPA12B 116835
Two-hybrid Homo sapiens
137 TNFRSF8 943
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-crystal Structure Homo sapiens
138 HSP90AB1 3326
Co-localization Homo sapiens
Co-fractionation Homo sapiens
139 TTC23  
Two-hybrid Homo sapiens
140 UBE2N 7334
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Phenotypic Suppression Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
141 FAM50B  
Two-hybrid Homo sapiens
142 RPS3 6188
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
143 PPP1R18 170954
Two-hybrid Homo sapiens
144 Khdrbs1 20218
Affinity Capture-Western Mus musculus
145 LENG1  
Two-hybrid Homo sapiens
146 TNIK 23043
Affinity Capture-Western Homo sapiens
147 MAP4K5 11183
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
148 TNFRSF12A 51330
Reconstituted Complex Homo sapiens
149 TCEB3B  
Two-hybrid Homo sapiens
150 CATSPER1  
Two-hybrid Homo sapiens
151 BIRC3 330
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
152 SETD5 55209
Two-hybrid Homo sapiens
153 AASDHPPT 60496
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
154 DDX6 1656
Two-hybrid Homo sapiens
155 AKR1B15  
Two-hybrid Homo sapiens
156 CCDC130  
Two-hybrid Homo sapiens
157 CUL1 8454
Affinity Capture-Western Homo sapiens
158 USP7 7874
Reconstituted Complex Homo sapiens
159 SOX5 6660
Two-hybrid Homo sapiens
160 USP53 54532
Two-hybrid Homo sapiens
161 GSK3B 2932
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
162 KANSL1  
Two-hybrid Homo sapiens
163 CXCL1 2919
Affinity Capture-MS Homo sapiens
164 AQP1 358
Two-hybrid Homo sapiens
165 IPO11 51194
Two-hybrid Homo sapiens
166 FAM161B  
Two-hybrid Homo sapiens
167 ZBTB16  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Co-localization Homo sapiens
168 TAB3 257397
Affinity Capture-Western Homo sapiens
169 UTP14C  
Two-hybrid Homo sapiens
170 C22orf15  
Two-hybrid Homo sapiens
171 VRK1 7443
Affinity Capture-MS Homo sapiens
172 RIN1 9610
Two-hybrid Homo sapiens
173 CLEC11A 6320
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
174 Tnfrsf14  
Two-hybrid Mus musculus
175 MALT1 10892
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
176 TMEM102  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
177 BCL6  
Two-hybrid Homo sapiens
178 NMUR2  
Two-hybrid Homo sapiens
179 CYLD  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
180 LONRF1  
Two-hybrid Homo sapiens
181 CD40 958
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
FRET Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-crystal Structure Homo sapiens
Affinity Capture-Western Homo sapiens
182 C17orf82  
Two-hybrid Homo sapiens
183 USP4 7375
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
184 DDI1  
Two-hybrid Homo sapiens
185 EAF1  
Two-hybrid Homo sapiens
186 ZBTB24  
Two-hybrid Homo sapiens
187 NCAPH2  
Two-hybrid Homo sapiens
188 PEG3 5178
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
189 TDP2 51567
Affinity Capture-Western Homo sapiens
190 DAB2IP 153090
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
191 KANK2 25959
Two-hybrid Homo sapiens
192 SPECC1 92521
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
193 TNFRSF18  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
194 FAM90A1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
195 MAP3K8  
Affinity Capture-RNA Homo sapiens
Affinity Capture-Western Homo sapiens
196 TSSC4  
Two-hybrid Homo sapiens
197 HOXA1 3198
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
PCA Homo sapiens
198 PACS2 23241
Reconstituted Complex Homo sapiens
199 EGFR 1956
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
PCA Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-Western Homo sapiens
200 CSNK2A2 1459
Affinity Capture-MS Homo sapiens
201 RIBC2  
Two-hybrid Homo sapiens
202 SHC3  
Two-hybrid Homo sapiens
203 RIPPLY3  
Two-hybrid Homo sapiens
204 MLKL 197259
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
205 ZRANB1 54764
Affinity Capture-MS Homo sapiens
206 SURF6  
Affinity Capture-MS Homo sapiens
207 TRAF3IP2  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
208 MUL1  
Affinity Capture-Western Homo sapiens
209 TIFA  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
210 ZFP36  
Affinity Capture-Western Homo sapiens
211 NEK6 10783
Two-hybrid Homo sapiens
212 KLF3  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
213 THOP1 7064
Two-hybrid Homo sapiens
214 SYT17  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
215 TROAP  
Two-hybrid Homo sapiens
216 PRKRIP1 79706
Two-hybrid Homo sapiens
217 BCL10  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
218 TNFRSF10B 8795
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
219 GPKOW  
Two-hybrid Homo sapiens
220 QRICH1  
Two-hybrid Homo sapiens
221 NAB2 4665
Two-hybrid Homo sapiens
222 PSMF1 9491
Two-hybrid Homo sapiens
223 EIF2AK2 5610
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
224 BRD1 23774
Affinity Capture-MS Homo sapiens
225 TRPT1 83707
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
226 SH3KBP1 30011
Affinity Capture-Western Homo sapiens
227 IKBKB 3551
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
228 LNX1  
Two-hybrid Homo sapiens
229 TRAIP  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
230 MVP 9961
Two-hybrid Homo sapiens
231 BAHD1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
232 PCGF5  
Two-hybrid Homo sapiens
233 MORN3  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
234 ZNF35  
Two-hybrid Homo sapiens
235 MAP4K2  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
236 EPB41L5 57669
Affinity Capture-MS Homo sapiens
237 ISCA1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
238 EPS15 2060
Affinity Capture-MS Homo sapiens
239 TRADD 8717
Affinity Capture-MS Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
240 ENKD1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
241 GAS8  
Two-hybrid Homo sapiens
242 EBF2  
Two-hybrid Homo sapiens
243 PCGF2 7703
Two-hybrid Homo sapiens
244 ZMAT2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
245 BRRF1  
Affinity Capture-Western
Affinity Capture-Western
246 PARK2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
247 RIPPLY1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
248 RHEBL1  
Affinity Capture-Western Homo sapiens
249 TAOK3 51347
Affinity Capture-Western Homo sapiens
250 CEP57L1  
Two-hybrid Homo sapiens
251 CHCHD2  
Two-hybrid Homo sapiens
252 RAB3IP  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
253 FBXO28  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
254 CALCOCO2  
Two-hybrid Homo sapiens
255 EWSR1 2130
Two-hybrid Homo sapiens
256 TCEA2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
257 EFEMP1 2202
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
258 IKBKE 9641
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
259 RASSF5 83593
Two-hybrid Homo sapiens
260 SOX30  
Two-hybrid Homo sapiens
261 MAVS 57506
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
262 UBQLN4 56893
Two-hybrid Homo sapiens
263 CFLAR  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
264 NIF3L1 60491
Two-hybrid Homo sapiens
265 APPL1 26060
Co-localization Homo sapiens
Two-hybrid Homo sapiens
266 UBE2V1 7335
Reconstituted Complex Homo sapiens
267 ZC2HC1C  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
268 KIAA1217 56243
Two-hybrid Homo sapiens
269 BANP  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
270 VEZF1  
Two-hybrid Homo sapiens
271 BAZ2B  
Two-hybrid Homo sapiens
272 ITGA6 3655
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
273 LRIT3  
Affinity Capture-MS Homo sapiens
274 CCDC33 80125
Two-hybrid Homo sapiens
275 TRIM42  
Two-hybrid Homo sapiens
276 TNFRSF17  
Affinity Capture-Western Homo sapiens
277 YAP1 10413
Affinity Capture-MS Homo sapiens
278 DIABLO 56616
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
279 ZBTB49 166793
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
280 NGFR 4804
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
281 TAB2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
282 ZNF572  
Two-hybrid Homo sapiens
283 ZNF655  
Two-hybrid Homo sapiens
284 ZSCAN32  
Two-hybrid Homo sapiens
285 FAM9A  
Two-hybrid Homo sapiens
286 ARSJ  
Two-hybrid Homo sapiens
287 DNM1L 10059
Proximity Label-MS Homo sapiens
288 EFHC1  
Two-hybrid Homo sapiens
289 ANKRD36BP1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
290 AHCY 191
Co-fractionation Homo sapiens
291 WNT3A 89780
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
292 ASCC1 51008
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
293 HOXB5  
Two-hybrid Homo sapiens
294 SARM1 23098
Affinity Capture-Western Homo sapiens
295 TMEM9B 56674
Affinity Capture-MS Homo sapiens
296 TRAF6 7189
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
297 NR3C1 2908
Proximity Label-MS Homo sapiens
298 ACTN3 89
Two-hybrid Homo sapiens
299 ITPRIPL1  
Two-hybrid Homo sapiens
300 MAP3K7  
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
301 DMTN  
Two-hybrid Homo sapiens
302 KIF26B  
Two-hybrid Homo sapiens
303 CD27  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
304 ADRBK1 156
Affinity Capture-Western Homo sapiens
305 CYB5R2 51700
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
306 FXR2 9513
Two-hybrid Homo sapiens
307 SEC16A 9919
Affinity Capture-Western Homo sapiens
308 MTOR 2475
Co-localization Homo sapiens
309 EDARADD  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
310 DGCR6  
Two-hybrid Homo sapiens
311 ZBTB25  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
312 TRAF2 7186
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Co-crystal Structure Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Biochemical Activity Homo sapiens
FRET Homo sapiens
Co-crystal Structure Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-crystal Structure Homo sapiens
Two-hybrid Homo sapiens
Co-crystal Structure Homo sapiens
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Co-crystal Structure Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Biochemical Activity Homo sapiens
FRET Homo sapiens
Co-crystal Structure Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-crystal Structure Homo sapiens
Two-hybrid Homo sapiens
Co-crystal Structure Homo sapiens
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
313 RNF2  
Affinity Capture-MS Homo sapiens
314 FBF1  
Two-hybrid Homo sapiens
315 MSN 4478
Co-fractionation Homo sapiens
316 CHUK 1147
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
317 ZNF417  
Two-hybrid Homo sapiens
318 SNAI1  
Two-hybrid Homo sapiens
319 TICAM1  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
320 SUMO1 7341
Two-hybrid Homo sapiens
321 UBE2D1 7321
Reconstituted Complex Homo sapiens
322 ZNF574  
Two-hybrid Homo sapiens
323 TEKT3 64518
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
324 MAP3K14  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
325 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
326 EPB41L4B 54566
Affinity Capture-MS Homo sapiens
327 TRIM33 51592
Affinity Capture-MS Homo sapiens
328 CDC40  
Co-crystal Structure Homo sapiens
329 PIN1 5300
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
330 RNF31 55072
Affinity Capture-MS Homo sapiens
331 CCHCR1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
332 IKBKG 8517
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
333 ZMYM5 9205
Two-hybrid Homo sapiens
334 CASP8 841
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
335 TNAP  
Affinity Capture-Western Homo sapiens
336 MKRN3  
Two-hybrid Homo sapiens
337 GPR107 57720
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
338 UBXN11  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
339 FOXN1  
Two-hybrid Homo sapiens
340 ZNF648  
Two-hybrid Homo sapiens
341 ZFAND6  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
342 TNFRSF11A  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
343 ZNF646  
Two-hybrid Homo sapiens
344 TRIM37  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
345 C20orf195  
Two-hybrid Homo sapiens
346 LRRK2 120892
Biochemical Activity Homo sapiens
347 FLNA 2316
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
348 CRYBA2  
Two-hybrid Homo sapiens
349 TNFRSF9  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-crystal Structure Homo sapiens
350 ANKRD11 29123
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
351 TNFRSF13C  
Affinity Capture-Western Homo sapiens
352 SH2D4A 63898
Two-hybrid Homo sapiens
353 CASP8AP2  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
354 ATXN3 4287
Affinity Capture-MS Homo sapiens
355 CAV1 857
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
356 UBE2V2 7336
Reconstituted Complex Homo sapiens
357 EP300 2033
Two-hybrid Homo sapiens
358 GSE1 23199
Two-hybrid Homo sapiens
359 MBLAC1 255374
Two-hybrid Homo sapiens
360 TNFAIP3 7128
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
361 Cd27  
Affinity Capture-Western Mus musculus
362 XAF1  
Affinity Capture-Western Homo sapiens
363 XIAP  
Affinity Capture-Western Homo sapiens
364 QARS 5859
Two-hybrid Homo sapiens
Co-fractionation Homo sapiens
Two-hybrid Homo sapiens
365 IRF4  
Two-hybrid Homo sapiens
366 ZNF438  
Two-hybrid Homo sapiens
367 TNFSF10 8743
Affinity Capture-Western Homo sapiens
368 TRAF4 9618
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
369 KIFC3 3801
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
370 FAM192A  
Two-hybrid Homo sapiens
371 MYO15B 80022
Two-hybrid Homo sapiens
372 SIVA1  
Affinity Capture-Western Homo sapiens
373 HSPA1L 3305
Co-localization Homo sapiens
374 UTP23  
Two-hybrid Homo sapiens
375 TAB1 10454
Affinity Capture-MS Homo sapiens
376 POM121  
Two-hybrid Homo sapiens
377 DVL3 1857
Two-hybrid Homo sapiens
378 NFIL3 4783
Two-hybrid Homo sapiens
379 KRTAP13-2  
Affinity Capture-MS Homo sapiens
380 ZNF662  
Two-hybrid Homo sapiens
381 USP31 57478
Affinity Capture-Western Homo sapiens
382 FNDC3B 64778
Two-hybrid Homo sapiens
383 YES1 7525
Two-hybrid Homo sapiens
384 ZNF488  
Two-hybrid Homo sapiens
385 RPS6KA3 6197
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
386 TRIM50  
Two-hybrid Homo sapiens
387 CASP1  
Affinity Capture-Western Homo sapiens
388 DYRK1A 1859
Affinity Capture-MS Homo sapiens
389 COPS5 10987
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
390 FBXW7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
391 IMPDH2 3615
Two-hybrid Homo sapiens
392 PSMD9 5715
Two-hybrid Homo sapiens
393 IFIT3 3437
Affinity Capture-Western Homo sapiens
394 AGR2 10551
Two-hybrid Homo sapiens
395 HINFP  
Two-hybrid Homo sapiens
396 USP2  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
397 MGC50722  
Two-hybrid Homo sapiens
398 TNFRSF1B  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Co-crystal Structure Homo sapiens
Affinity Capture-Western Homo sapiens
399 DVL2 1856
Two-hybrid Homo sapiens
400 CTCF  
Two-hybrid Homo sapiens
401 TNF  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
402 LTBR 4055
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
403 APOO 79135
Proximity Label-MS Homo sapiens
404 DNASE2B  
Affinity Capture-MS Homo sapiens
405 FARS2 10667
Two-hybrid Homo sapiens
406 RB1CC1 9821
Affinity Capture-Western Homo sapiens
407 MOS 4342
Two-hybrid Homo sapiens
408 GCKR  
Reconstituted Complex Homo sapiens
409 Srsf1 110809
Affinity Capture-MS Mus musculus
410 RNF146  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
411 FAM107A  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
412 TRIM14 9830
Two-hybrid Homo sapiens
413 NECAP2 55707
Two-hybrid Homo sapiens
414 GEM  
Two-hybrid Homo sapiens
415 WDYHV1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
416 HIVEP3 59269
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
417 PIAS2  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
418 SPATA2  
Two-hybrid Homo sapiens
419 LPIN3 64900
Affinity Capture-MS Homo sapiens
420 CRY2  
Two-hybrid Homo sapiens
421 PCSK9 255738
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
422 PML 5371
Affinity Capture-MS Homo sapiens
423 RAD54L2  
Two-hybrid Homo sapiens
424 FAM124B  
Two-hybrid Homo sapiens
425 CDK9 1025
Affinity Capture-Western Homo sapiens
426 ZKSCAN3  
Two-hybrid Homo sapiens
427 ZC3H15 55854
Affinity Capture-Western Homo sapiens
428 H2AFY 9555
Two-hybrid Homo sapiens
429 PPP4R1 9989
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
430 NEBL 10529
Two-hybrid Homo sapiens
431 UBE2I 7329
Two-hybrid Homo sapiens
432 IP6K2  
Affinity Capture-Western Homo sapiens
433 FAM161A  
Two-hybrid Homo sapiens
434 IL15RA 3601
Affinity Capture-Western Homo sapiens
435 GOLGA3 2802
Affinity Capture-MS Homo sapiens
436 TCL1A  
Two-hybrid Homo sapiens
437 HARS 3035
Co-fractionation Homo sapiens
438 CAPN15  
Two-hybrid Homo sapiens
439 EIF4G1 1981
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
440 SRSF1 6426
Affinity Capture-Western Homo sapiens
441 TIGD4 201798
Two-hybrid Homo sapiens
442 ARHGEF6 9459
Two-hybrid Homo sapiens
443 MAP3K1 4214
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
444 EP400  
Two-hybrid Homo sapiens
445 CCNJL  
Two-hybrid Homo sapiens
446 TRAF3 7187
Affinity Capture-MS Homo sapiens
FRET Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
447 NATD1  
Two-hybrid Homo sapiens
448 Hoxa1  
Two-hybrid Mus musculus
Affinity Capture-Western Mus musculus
449 JUN 3725
Biochemical Activity Homo sapiens
450 LZTS2 84445
Two-hybrid Homo sapiens
451 UBE2D2 7322
Reconstituted Complex Homo sapiens
452 PGBD1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
453 ZNF544  
Two-hybrid Homo sapiens
454 INO80B 83444
Two-hybrid Homo sapiens
455 TSHZ3  
Two-hybrid Homo sapiens
456 ARNT2  
Two-hybrid Homo sapiens
457 GABPB1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
458 PPP1R32  
Two-hybrid Homo sapiens
459 RNASET2  
Affinity Capture-Western Homo sapiens
460 ZSWIM3  
Two-hybrid Homo sapiens
461 FATE1  
Two-hybrid Homo sapiens
462 DLGAP5  
Two-hybrid Homo sapiens
463 EXOC3-AS1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
464 ALS2CR11  
Two-hybrid Homo sapiens
465 LRRN2 10446
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
466 RALBP1 10928
Co-localization Homo sapiens
467 PDLIM7 9260
PCA Homo sapiens
PCA Homo sapiens
468 GCA 25801
Two-hybrid Homo sapiens
469 ZSCAN23  
Two-hybrid Homo sapiens
470 HSPB2  
Affinity Capture-Western Homo sapiens
471 SPRY2 10253
Two-hybrid Homo sapiens
472 PDIA5 10954
Affinity Capture-MS Homo sapiens
473 Tnfrsf1b  
Affinity Capture-Western Mus musculus
Two-hybrid Mus musculus
474 CASP7  
Affinity Capture-MS Homo sapiens
475 TMC8 147138
Affinity Capture-Western Homo sapiens
476 OSTM1 28962
Affinity Capture-MS Homo sapiens
477 RAPGEF4  
Two-hybrid Homo sapiens
478 CDK18 5129
Two-hybrid Homo sapiens
479 SMURF1 57154
Phenotypic Suppression Homo sapiens
480 ELAVL1 1994
Affinity Capture-Western Homo sapiens
481 GPANK1  
Two-hybrid Homo sapiens
482 THAP7  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
483 MAST2  
Affinity Capture-Western Homo sapiens
484 TXN 7295
Two-hybrid Homo sapiens
485 SMYD2 56950
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
486 VWA2 340706
Two-hybrid Homo sapiens
487 MAPK9 5601
Co-localization Homo sapiens
488 RXRA 6256
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
489 TRIM31  
Two-hybrid Homo sapiens
490 CBX8 57332
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
491 TCAF1 9747
Two-hybrid Homo sapiens
492 MAP3K11 4296
Affinity Capture-Western Homo sapiens
493 MFAP1  
Two-hybrid Homo sapiens
494 SOX13  
Two-hybrid Homo sapiens
495 GNB2L1 10399
Affinity Capture-Western Homo sapiens
496 USF1  
Two-hybrid Homo sapiens
497 SPG21 51324
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
498 CDC20B  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
499 KIAA0408  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which TRAF2 is involved
PathwayEvidenceSource
Apoptosis TAS Reactome
CASP8 activity is inhibited TAS Reactome
Caspase activation via Death Receptors in the presence of ligand TAS Reactome
Caspase activation via extrinsic apoptotic signalling pathway TAS Reactome
Cytokine Signaling in Immune system TAS Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta TAS Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta IEA Reactome
Death Receptor Signaling TAS Reactome
Defective RIPK1-mediated regulated necrosis TAS Reactome
Deubiquitination TAS Reactome
Dimerization of procaspase-8 TAS Reactome
Disease TAS Reactome
Diseases of programmed cell death TAS Reactome
Immune System TAS Reactome
Immune System IEA Reactome
Innate Immune System TAS Reactome
Innate Immune System IEA Reactome
Interleukin-1 family signaling TAS Reactome
Interleukin-1 signaling TAS Reactome
Metabolism of proteins TAS Reactome
MyD88 cascade initiated on plasma membrane TAS Reactome
MyD88 dependent cascade initiated on endosome TAS Reactome
MyD88-independent TLR4 cascade TAS Reactome
MyD88:MAL(TIRAP) cascade initiated on plasma membrane TAS Reactome
Post-translational protein modification TAS Reactome
Programmed Cell Death TAS Reactome
Regulated Necrosis TAS Reactome
Regulation by c-FLIP TAS Reactome
Regulation of necroptotic cell death TAS Reactome
Regulation of NF-kappa B signaling TAS Reactome
Regulation of TNFR1 signaling TAS Reactome
RIPK1-mediated regulated necrosis TAS Reactome
Signal Transduction TAS Reactome
Signaling by Interleukins TAS Reactome
TAK1-dependent IKK and NF-kappa-B activation TAS Reactome
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway TAS Reactome
TNF signaling TAS Reactome
TNFR1-induced NF-kappa-B signaling pathway TAS Reactome
TNFR1-induced proapoptotic signaling TAS Reactome
TNFR2 non-canonical NF-kB pathway TAS Reactome
Toll Like Receptor 10 (TLR10) Cascade TAS Reactome
Toll Like Receptor 2 (TLR2) Cascade TAS Reactome
Toll Like Receptor 3 (TLR3) Cascade TAS Reactome
Toll Like Receptor 4 (TLR4) Cascade TAS Reactome
Toll Like Receptor 5 (TLR5) Cascade TAS Reactome
Toll Like Receptor 7/8 (TLR7/8) Cascade TAS Reactome
Toll Like Receptor 9 (TLR9) Cascade TAS Reactome
Toll Like Receptor TLR1:TLR2 Cascade TAS Reactome
Toll Like Receptor TLR6:TLR2 Cascade TAS Reactome
Toll-like Receptor Cascades TAS Reactome
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation TAS Reactome
TRAF6 mediated IRF7 activation TAS Reactome
TRAF6 mediated NF-kB activation TAS Reactome
TRAF6 mediated NF-kB activation IEA Reactome
TRIF (TICAM1)-mediated TLR4 signaling TAS Reactome
Ub-specific processing proteases TAS Reactome





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