Gene description for HIVEP3
Gene name human immunodeficiency virus type I enhancer binding protein 3
Gene symbol HIVEP3
Other names/aliases KBP-1
KBP1
KRC
SHN3
Schnurri-3
ZAS3
ZNF40C
Species Homo sapiens
 Database cross references - HIVEP3
ExoCarta ExoCarta_59269
Vesiclepedia VP_59269
Entrez Gene 59269
HGNC 13561
MIM 606649
UniProt Q5T1R4  
 HIVEP3 identified in sEVs derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
Hepatocytes 26054723    
 Gene ontology annotations for HIVEP3
Molecular Function
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA
    protein binding GO:0005515 IPI
    metal ion binding GO:0046872 IEA
Biological Process
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    skeletal muscle cell differentiation GO:0035914 IEA
    positive regulation of DNA-templated transcription GO:0045893 IDA
Subcellular Localization
    nucleus GO:0005634 IBA
    cytoplasm GO:0005737 IEA
 Experiment description of studies that identified HIVEP3 in sEVs
1
Experiment ID 236
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
2
Experiment ID 237
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for HIVEP3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PNN 5411
Cross-Linking-MS (XL-MS) Homo sapiens
2 GRSF1 2926
Two-hybrid Homo sapiens
3 FHL1 2273
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
4 TRAF2 7186
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
5 UBC 7316
Affinity Capture-MS Homo sapiens
6 FUS 2521
Affinity Capture-MS Homo sapiens
7 WWP1 11059
Affinity Capture-Western Homo sapiens
8 RUNX2  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
9 TRAF1 7185
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml



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