Gene description for TNFRSF8
Gene name tumor necrosis factor receptor superfamily, member 8
Gene symbol TNFRSF8
Other names/aliases CD30
D1S166E
Ki-1
Species Homo sapiens
 Database cross references - TNFRSF8
ExoCarta ExoCarta_943
Vesiclepedia VP_943
Entrez Gene 943
HGNC 11923
MIM 153243
UniProt P28908  
 TNFRSF8 identified in sEVs derived from the following tissue/cell type
B cells 20458337    
B cells 20458337    
B cells 20458337    
 Gene ontology annotations for TNFRSF8
Molecular Function
    protease binding GO:0002020 IPI
    transmembrane signaling receptor activity GO:0004888 IEA
Biological Process
    signal transduction GO:0007165 IEA
    negative regulation of cell population proliferation GO:0008285 TAS
    positive regulation of TRAIL production GO:0032759 IDA
    positive regulation of tumor necrosis factor production GO:0032760 IDA
    positive regulation of apoptotic process GO:0043065 IDA
    cellular response to mechanical stimulus GO:0071260 IEP
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IEA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified TNFRSF8 in sEVs
1
Experiment ID 79
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis - Sample 1
Authors "Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W."
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
2
Experiment ID 80
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis -Sample 2
Authors "Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W."
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
3
Experiment ID 81
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis - Sample 3
Authors "Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W."
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
 Protein-protein interactions for TNFRSF8
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TRAIP  
Affinity Capture-Western Homo sapiens
2 NAA25 80018
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 CEP57  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 SPATS2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 Traf1  
Two-hybrid Mus musculus
Affinity Capture-Western Mus musculus
Reconstituted Complex Mus musculus
6 TRAF2 7186
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 KIF3A 11127
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 Traf2  
Two-hybrid Mus musculus
Affinity Capture-Western Mus musculus
Reconstituted Complex Mus musculus
9 GOLPH3 64083
Affinity Capture-MS Homo sapiens
10 NAA20  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 TNFSF8  
Reconstituted Complex Homo sapiens
12 ATP6V1D 51382
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 TNFRSF8 943
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
14 CDC6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 DPY19L1 23333
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 TRAF3 7187
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 RACGAP1 29127
Affinity Capture-MS Homo sapiens
18 SNAP47 116841
Affinity Capture-MS Homo sapiens
19 BLOC1S1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 GOLPH3L 55204
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 NDC1 55706
Affinity Capture-MS Homo sapiens
22 DAPK3 1613
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 EXOC1 55763
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 TRAF5  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
25 BCL6  
Affinity Capture-MS Homo sapiens
26 TDP2 51567
Affinity Capture-Western Homo sapiens
27 FHL2 2274
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 CCDC112  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 TRAF1 7185
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
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