Gene description for RASSF5
Gene name Ras association (RalGDS/AF-6) domain family member 5
Gene symbol RASSF5
Other names/aliases Maxp1
NORE1
NORE1A
NORE1B
RAPL
RASSF3
Species Homo sapiens
 Database cross references - RASSF5
ExoCarta ExoCarta_83593
Entrez Gene 83593
HGNC 17609
MIM 607020
UniProt Q8WWW0  
 RASSF5 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for RASSF5
Molecular Function
    protein binding GO:0005515 IPI
    metal ion binding GO:0046872 IEA
Biological Process
    positive regulation of protein ubiquitination GO:0031398 IEA
    negative regulation of cell proliferation GO:0008285 IEA
    apoptotic process GO:0006915 IEA
    regulation of protein localization to nucleus GO:1900180 IEA
    intracellular signal transduction GO:0035556 IEA
Subcellular Localization
    microtubule GO:0005874 IEA
    nucleus GO:0005634 IEA
    cytoplasm GO:0005737 IEA
 Experiment description of studies that identified RASSF5 in exosomes
1
Experiment ID 236
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for RASSF5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 KRAS 3845
Reconstituted Complex Homo sapiens
2 STK4 6789
Invivo Homo sapiens
3 HRAS 3265
Reconstituted Complex Homo sapiens
4 RAP1B 5908
Invivo Homo sapiens
Invitro Homo sapiens
5 RASSF1  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
6 RRAS 6237
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
7 RASSF5 83593
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
8 MRAS  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
9 RASSF2 9770
Reconstituted Complex Homo sapiens
10 RAP2A 5911
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which RASSF5 is involved
No pathways found





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