Gene description for TRAF3
Gene name	TNF receptor-associated factor 3
Gene symbol	TRAF3
Other names/aliases	CAP-1 CAP1 CD40bp CRAF1 IIAE5 LAP1
Species	Homo sapiens
Database cross references - TRAF3
ExoCarta	ExoCarta_7187
Vesiclepedia	VP_7187
Entrez Gene	7187
HGNC	12033
MIM	601896
UniProt	Q13114
TRAF3 identified in sEVs derived from the following tissue/cell type
Hepatocellular carcinoma cells	26054723

Gene ontology annotations for TRAF3

Molecular Function     ubiquitin-protein transferase activity GO:0004842 IDA     ubiquitin-protein transferase activity GO:0004842 TAS     tumor necrosis factor receptor binding GO:0005164 IPI     protein binding GO:0005515 IPI     zinc ion binding GO:0008270 IEA     protein kinase binding GO:0019901 IEA     protein phosphatase binding GO:0019903 IPI     ubiquitin protein ligase binding GO:0031625 IPI     thioesterase binding GO:0031996 IPI     signaling adaptor activity GO:0035591 IBA     identical protein binding GO:0042802 IPI     ubiquitin protein ligase activity GO:0061630 IDA Biological Process     regulation of cytokine production GO:0001817 ISS     toll-like receptor signaling pathway GO:0002224 IDA     toll-like receptor signaling pathway GO:0002224 ISS     apoptotic process GO:0006915 IEA     signal transduction GO:0007165 TAS     cell surface receptor signaling pathway GO:0007166 IBA     Toll signaling pathway GO:0008063 IEA     regulation of proteolysis GO:0030162 IMP     negative regulation of NF-kappaB transcription factor activity GO:0032088 IMP     positive regulation of type I interferon production GO:0032481 IDA     regulation of interferon-beta production GO:0032648 ISS     tumor necrosis factor-mediated signaling pathway GO:0033209 IMP     toll-like receptor 4 signaling pathway GO:0034142 IDA     TRIF-dependent toll-like receptor signaling pathway GO:0035666 TAS     regulation of apoptotic process GO:0042981 IEA     regulation of canonical NF-kappaB signal transduction GO:0043122 IBA     regulation of defense response to virus GO:0050688 ISS     defense response to virus GO:0051607 NAS     type I interferon-mediated signaling pathway GO:0060337 NAS Subcellular Localization     ubiquitin ligase complex GO:0000151 NAS     cytoplasm GO:0005737 IBA     mitochondrion GO:0005739 IC     mitochondrion GO:0005739 IDA     endosome GO:0005768 IDA     cytosol GO:0005829 TAS     cytoplasmic side of plasma membrane GO:0009898 ISS     endosome membrane GO:0010008 IDA     CD40 receptor complex GO:0035631 ISS     plasma membrane signaling receptor complex GO:0098802 IBA     serine/threonine protein kinase complex GO:1902554 NAS