Gene description for TRAF3
Gene name TNF receptor-associated factor 3
Gene symbol TRAF3
Other names/aliases CAP-1
CAP1
CD40bp
CRAF1
IIAE5
LAP1
Species Homo sapiens
 Database cross references - TRAF3
ExoCarta ExoCarta_7187
Vesiclepedia VP_7187
Entrez Gene 7187
HGNC 12033
MIM 601896
UniProt Q13114  
 TRAF3 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for TRAF3
Molecular Function
    ubiquitin-protein transferase activity GO:0004842 IDA
    ubiquitin-protein transferase activity GO:0004842 TAS
    tumor necrosis factor receptor binding GO:0005164 IPI
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 IEA
    protein kinase binding GO:0019901 IEA
    protein phosphatase binding GO:0019903 IPI
    ubiquitin protein ligase binding GO:0031625 IPI
    thioesterase binding GO:0031996 IPI
    signaling adaptor activity GO:0035591 IBA
    identical protein binding GO:0042802 IPI
    ubiquitin protein ligase activity GO:0061630 IDA
Biological Process
    regulation of cytokine production GO:0001817 ISS
    toll-like receptor signaling pathway GO:0002224 IDA
    toll-like receptor signaling pathway GO:0002224 ISS
    apoptotic process GO:0006915 IEA
    signal transduction GO:0007165 TAS
    cell surface receptor signaling pathway GO:0007166 IBA
    Toll signaling pathway GO:0008063 IEA
    regulation of proteolysis GO:0030162 IMP
    negative regulation of NF-kappaB transcription factor activity GO:0032088 IMP
    positive regulation of type I interferon production GO:0032481 IDA
    regulation of interferon-beta production GO:0032648 ISS
    tumor necrosis factor-mediated signaling pathway GO:0033209 IMP
    toll-like receptor 4 signaling pathway GO:0034142 IDA
    TRIF-dependent toll-like receptor signaling pathway GO:0035666 TAS
    regulation of apoptotic process GO:0042981 IEA
    regulation of canonical NF-kappaB signal transduction GO:0043122 IBA
    regulation of defense response to virus GO:0050688 ISS
    defense response to virus GO:0051607 NAS
    type I interferon-mediated signaling pathway GO:0060337 NAS
Subcellular Localization
    ubiquitin ligase complex GO:0000151 NAS
    cytoplasm GO:0005737 IBA
    mitochondrion GO:0005739 IC
    mitochondrion GO:0005739 IDA
    endosome GO:0005768 IDA
    cytosol GO:0005829 TAS
    cytoplasmic side of plasma membrane GO:0009898 ISS
    endosome membrane GO:0010008 IDA
    CD40 receptor complex GO:0035631 ISS
    plasma membrane signaling receptor complex GO:0098802 IBA
    serine/threonine protein kinase complex GO:1902554 NAS
 Experiment description of studies that identified TRAF3 in exosomes
1
Experiment ID 235
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for TRAF3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TRAIP  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
2 TRAF3IP3  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
3 OTUD5 55593
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
4 PPP3CA 5530
Affinity Capture-Western Homo sapiens
5 TNIP1 10318
Affinity Capture-Western Homo sapiens
6 ETV6  
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 GALC 2581
Affinity Capture-MS Homo sapiens
8 NUP62 23636
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
9 ABCF1 23
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
10 TNFRSF8 943
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 NMRAL1 57407
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
12 WDYHV1  
Two-hybrid Homo sapiens
13 POM121  
Two-hybrid Homo sapiens
14 RIPK1 8737
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
15 RNF216  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
16 PSMB8 5696
Two-hybrid Homo sapiens
17 TIFA  
Affinity Capture-Western Homo sapiens
18 LGALS3BP 3959
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
19 MYT1  
Affinity Capture-MS Homo sapiens
20 MAP3K5 4217
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
21 USO1 8615
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
22 DYRK1A 1859
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
23 TLR3  
Affinity Capture-MS Homo sapiens
24 CASP3 836
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
25 Tnfrsf12a  
Two-hybrid Mus musculus
26 SRC 6714
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
27 TDP2 51567
Affinity Capture-Western Homo sapiens
28 ZMYND11 10771
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
29 SYK 6850
Affinity Capture-Western Homo sapiens
30 OTUB2  
Affinity Capture-Western Homo sapiens
31 IFIT3 3437
Affinity Capture-Western Homo sapiens
32 EWSR1 2130
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
33 OTUD7B 56957
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
34 IKBKE 9641
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
35 TNFRSF13B  
Affinity Capture-Western Homo sapiens
36 RIPK2  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
37 MAVS 57506
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
38 RNF126  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
39 CBLB 868
Affinity Capture-Western Homo sapiens
40 PPP3R1 5534
Affinity Capture-Western Homo sapiens
41 USP7 7874
Reconstituted Complex Homo sapiens
42 TNFRSF1B  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
43 CFLAR  
Affinity Capture-Western Homo sapiens
44 RBM14 10432
Affinity Capture-MS Homo sapiens
45 TNFRSF4  
Affinity Capture-Western Homo sapiens
46 FAS 355
Reconstituted Complex Homo sapiens
47 LTBR 4055
Affinity Capture-Western Homo sapiens
Phenotypic Suppression Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-crystal Structure Homo sapiens
48 TNFRSF14  
Reconstituted Complex Homo sapiens
49 OPTN 10133
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
50 NLRX1 79671
Affinity Capture-Western Homo sapiens
51 TRIM14 9830
Affinity Capture-Western Homo sapiens
52 APOBEC3C 27350
Two-hybrid Homo sapiens
53 TNFRSF17  
Affinity Capture-Western Homo sapiens
54 TRIM24  
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
55 AZI2  
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
56 UBE2I 7329
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
57 IL15  
Two-hybrid Homo sapiens
58 ZBTB49 166793
Two-hybrid Homo sapiens
59 NGFR 4804
Affinity Capture-Western Homo sapiens
60 CCDC184  
Two-hybrid Homo sapiens
61 RNF166  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
62 HEMGN  
Two-hybrid Homo sapiens
63 ULK1  
Affinity Capture-Western Homo sapiens
64 CSNK1E 1454
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
65 SHPK 23729
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 NFATC2IP  
Affinity Capture-Western Homo sapiens
67 PRKACB 5567
Affinity Capture-Western Homo sapiens
68 DAXX  
Two-hybrid Homo sapiens
69 BIRC3 330
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
70 SNAP29 9342
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 BIRC2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
72 CD40 958
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
73 ZSCAN4  
Two-hybrid Homo sapiens
74 DCAF7 10238
Affinity Capture-MS Homo sapiens
75 TAX1BP1 8887
Affinity Capture-Western Homo sapiens
76 PTPN6 5777
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
77 SAR1A 56681
Two-hybrid Homo sapiens
78 ASCC1 51008
Two-hybrid Homo sapiens
79 LMP1 3783750
Two-hybrid
Reconstituted Complex
80 TRAF3IP1 26146
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
81 FOXO1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
82 TNFRSF1A 7132
Reconstituted Complex Homo sapiens
83 CUL3 8452
Affinity Capture-MS Homo sapiens
84 CCDC13 152206
Two-hybrid Homo sapiens
85 TNFRSF18  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
86 MAP3K7  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
87 TRAF3 7187
Two-hybrid Homo sapiens
FRET Homo sapiens
Affinity Capture-Western Homo sapiens
Co-crystal Structure Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
FRET Homo sapiens
Affinity Capture-Western Homo sapiens
Co-crystal Structure Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
88 NCKAP5  
Affinity Capture-MS Homo sapiens
89 TFG 10342
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
90 C10orf62  
Two-hybrid Homo sapiens
91 BLK 640
Affinity Capture-Western Homo sapiens
92 CD27  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
93 TMEM173  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
94 WDR5 11091
Affinity Capture-Western Homo sapiens
95 EDA2R  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
96 PCDH10 57575
Affinity Capture-MS Homo sapiens
97 SEC16A 9919
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
98 DAZL  
Affinity Capture-MS Homo sapiens
99 ABCC1 4363
Two-hybrid Homo sapiens
100 TRAF5  
Affinity Capture-MS Homo sapiens
Co-localization Homo sapiens
FRET Homo sapiens
101 IP6K3  
Two-hybrid Homo sapiens
102 ECH1 1891
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
103 ATP1B1 481
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
104 TLR4  
Affinity Capture-MS Homo sapiens
105 IRF1  
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
106 IRF3 3661
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
107 NEDD4L 23327
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
108 TICAM1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
109 RAD23A 5886
Two-hybrid Homo sapiens
110 PDLIM7 9260
PCA Homo sapiens
PCA Homo sapiens
111 MAP3K14  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
112 TANK 10010
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Co-crystal Structure Homo sapiens
113 TRAF3IP2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
114 TRAF2 7186
Affinity Capture-MS Homo sapiens
FRET Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
115 FAM53C 51307
Affinity Capture-MS Homo sapiens
116 UBE2O 63893
Affinity Capture-Western Homo sapiens
117 USP1 7398
Affinity Capture-Western Homo sapiens
118 GMEB2  
Two-hybrid Homo sapiens
119 FOSL1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
120 SPP1 6696
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
121 DDX3X 1654
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
122 RIPPLY1  
Two-hybrid Homo sapiens
123 PPP1CC 5501
Affinity Capture-Western Homo sapiens
124 TNFSF14  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
125 CDC37 11140
Two-hybrid Homo sapiens
126 IKBKG 8517
Affinity Capture-Western Homo sapiens
127 TNAP  
Affinity Capture-Western Homo sapiens
128 SMURF1 57154
Phenotypic Suppression Homo sapiens
129 TROAP  
Affinity Capture-MS Homo sapiens
130 ZBP1  
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
131 BIVM  
Two-hybrid Homo sapiens
132 OTUB1 55611
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
133 CREB1  
Affinity Capture-Western Homo sapiens
134 ESR1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
135 TLR9  
Affinity Capture-MS Homo sapiens
136 HECTD3 79654
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
137 TBK1 29110
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
138 TNFRSF11A  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
139 TRIM37  
Reconstituted Complex Homo sapiens
140 KRT38 8687
Affinity Capture-MS Homo sapiens
141 MYD88 4615
Affinity Capture-Western Homo sapiens
142 TNFRSF9  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
143 TSKS  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
144 TNFRSF13C  
Affinity Capture-Western Homo sapiens
Co-crystal Structure Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
145 VAV3 10451
Affinity Capture-Western Homo sapiens
146 TRAF1 7185
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
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