Gene description for TRAF3
Gene name	TNF receptor-associated factor 3
Gene symbol	TRAF3
Other names/aliases	CAP-1 CAP1 CD40bp CRAF1 IIAE5 LAP1
Species	Homo sapiens
Database cross references - TRAF3
ExoCarta	ExoCarta_7187
Entrez Gene	7187
HGNC	12033
MIM	601896
UniProt	Q13114
TRAF3 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells	26054723

Gene ontology annotations for TRAF3

Molecular Function     ligase activity GO:0016874 IEA     protein binding GO:0005515 IPI     signal transducer activity GO:0004871 TAS     ubiquitin protein ligase binding GO:0031625 IPI     zinc ion binding GO:0008270 IEA     protein kinase binding GO:0019901 IEA     thioesterase binding GO:0031996 IPI     ubiquitin-protein transferase activity GO:0004842 IEA     tumor necrosis factor receptor binding GO:0005164 IPI Biological Process     regulation of apoptotic process GO:0042981 IEA     regulation of proteolysis GO:0030162 IMP     toll-like receptor 4 signaling pathway GO:0034142 TAS     protein ubiquitination GO:0016567 IEA     negative regulation of NF-kappaB transcription factor activity GO:0032088 IMP     TRIF-dependent toll-like receptor signaling pathway GO:0035666 TAS     regulation of cytokine production GO:0001817 ISS     innate immune response GO:0045087 TAS     Toll signaling pathway GO:0008063 IEA     toll-like receptor signaling pathway GO:0002224 TAS     MyD88-independent toll-like receptor signaling pathway GO:0002756 TAS     toll-like receptor 3 signaling pathway GO:0034138 TAS     regulation of defense response to virus GO:0050688 ISS     apoptotic process GO:0006915 IEA     negative regulation of type I interferon production GO:0032480 TAS     regulation of interferon-beta production GO:0032648 ISS     tumor necrosis factor-mediated signaling pathway GO:0033209 IMP     signal transduction GO:0007165 TAS Subcellular Localization     endosome GO:0005768 IEA     mitochondrion GO:0005739 IEA     cytoplasmic side of plasma membrane GO:0009898 ISS     cytosol GO:0005829 TAS     CD40 receptor complex GO:0035631 ISS