Gene description for CDK18
Gene name cyclin-dependent kinase 18
Gene symbol CDK18
Other names/aliases PCTAIRE
PCTAIRE3
PCTK3
Species Homo sapiens
 Database cross references - CDK18
ExoCarta ExoCarta_5129
Vesiclepedia VP_5129
Entrez Gene 5129
HGNC 8751
MIM 169190
UniProt Q07002  
 CDK18 identified in exosomes derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
Squamous carcinoma cells 20124223    
Thymus 23844026    
 Gene ontology annotations for CDK18
Molecular Function
    cyclin-dependent protein serine/threonine kinase activity GO:0004693 IBA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    protein serine kinase activity GO:0106310 IEA
Biological Process
    positive regulation of myelination GO:0031643 IDA
    regulation of cell cycle phase transition GO:1901987 IBA
Subcellular Localization
    nucleus GO:0005634 IBA
    cytoplasm GO:0005737 IBA
    mitochondrion GO:0005739 HTP
 Experiment description of studies that identified CDK18 in exosomes
1
Experiment ID 834
MISEV standards
EM
Biophysical techniques
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
EM
Biophysical techniques
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
3
Experiment ID 191
MISEV standards
Biophysical techniques
Alix|CD81|CD9
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors "Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK."
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 217
MISEV standards
EM
Biophysical techniques
TSG101|CD81|CD9|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CDK18
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CDK17 5128
Affinity Capture-MS Homo sapiens
2 CCDC88B 283234
Two-hybrid Homo sapiens
3 UBL4A 8266
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 ZNF438  
Two-hybrid Homo sapiens
5 KIFC3 3801
Two-hybrid Homo sapiens
6 YWHAE 7531
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 REL 5966
Two-hybrid Homo sapiens
8 RPL37A 6168
Affinity Capture-MS Homo sapiens
9 HSP90AB1 3326
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 TTC23  
Two-hybrid Homo sapiens
11 FUBP3 8939
Affinity Capture-MS Homo sapiens
12 CBY1  
Affinity Capture-MS Homo sapiens
13 CCDC102B  
Two-hybrid Homo sapiens
14 ZNF426  
Two-hybrid Homo sapiens
15 TRIM54  
Two-hybrid Homo sapiens
16 CCNK  
Two-hybrid Homo sapiens
17 MASTL  
Affinity Capture-MS Homo sapiens
18 TRIM50  
Two-hybrid Homo sapiens
19 DYRK1A 1859
Affinity Capture-MS Homo sapiens
20 RAB3IP  
Affinity Capture-MS Homo sapiens
21 FBXW7  
Synthetic Lethality Homo sapiens
22 KRT40  
Two-hybrid Homo sapiens
23 YWHAG 7532
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 MTUS2 23281
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
25 MAGED2 10916
Affinity Capture-MS Homo sapiens
26 KRT31 3881
Two-hybrid Homo sapiens
27 HSP90AA5P 730211
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 SFXN2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 P3H1 64175
Affinity Capture-MS Homo sapiens
30 HAP1  
Two-hybrid Homo sapiens
31 FSD2 123722
Two-hybrid Homo sapiens
32 CCNDBP1 23582
Two-hybrid Homo sapiens
33 MTA2 9219
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 LARP4B 23185
Affinity Capture-MS Homo sapiens
35 YWHAB 7529
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 GOLGA6L9  
Two-hybrid Homo sapiens
37 KRT34  
Two-hybrid Homo sapiens
38 CDK16 5127
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 DNLZ  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 PPP5C 5536
Affinity Capture-MS Homo sapiens
41 CDKN1A  
Affinity Capture-MS Homo sapiens
42 CDK5 1020
Affinity Capture-MS Homo sapiens
43 BAG6 7917
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 GOLGA2 2801
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
45 PPP2CB 5516
Affinity Capture-MS Homo sapiens
46 SPERT  
Two-hybrid Homo sapiens
47 YWHAH 7533
Affinity Capture-MS Homo sapiens
48 GORASP2 26003
Two-hybrid Homo sapiens
49 KRT75 9119
Two-hybrid Homo sapiens
50 C17orf70  
Affinity Capture-MS Homo sapiens
51 NSRP1  
Affinity Capture-MS Homo sapiens
52 S100B 6285
Affinity Capture-MS Homo sapiens
53 PML 5371
Affinity Capture-MS Homo sapiens
54 CEP76  
Two-hybrid Homo sapiens
55 DUSP7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 MTR 4548
Affinity Capture-MS Homo sapiens
57 GNB4 59345
Affinity Capture-MS Homo sapiens
58 KRT86  
Two-hybrid Homo sapiens
59 EEF2 1938
Affinity Capture-MS Homo sapiens
60 YWHAZ 7534
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 HMBOX1  
Two-hybrid Homo sapiens
62 LZTS2 84445
Two-hybrid Homo sapiens
63 KRT15 3866
Two-hybrid Homo sapiens
64 FKBP5 2289
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 Tpx2  
Affinity Capture-MS Mus musculus
66 YWHAQ 10971
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
67 CCDC85B  
Two-hybrid Homo sapiens
68 ACKR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 TRIM27  
Two-hybrid Homo sapiens
70 CTSB 1508
Affinity Capture-MS Homo sapiens
71 PPFIA1 8500
Two-hybrid Homo sapiens
72 CCDC125 202243
Two-hybrid Homo sapiens
73 TSGA10  
Two-hybrid Homo sapiens
74 STUB1 10273
Affinity Capture-MS Homo sapiens
75 APP 351
Reconstituted Complex Homo sapiens
76 NUTM1  
Two-hybrid Homo sapiens
77 FGR 2268
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
78 TRAF2 7186
Two-hybrid Homo sapiens
79 KRT16 3868
Two-hybrid Homo sapiens
80 TRPS1  
Affinity Capture-MS Homo sapiens
81 AK8  
Two-hybrid Homo sapiens
82 VPS28 51160
Two-hybrid Homo sapiens
83 Psmb4 19172
Affinity Capture-MS Mus musculus
84 CA4 762
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
85 EIF3I 8668
Affinity Capture-MS Homo sapiens
86 FXR1 8087
Affinity Capture-MS Homo sapiens
87 BLZF1  
Two-hybrid Homo sapiens
88 CDC37 11140
Affinity Capture-MS Homo sapiens
89 VPS52 6293
Two-hybrid Homo sapiens
90 CDK15  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
91 PNMA1 9240
Two-hybrid Homo sapiens
92 HSP90AA1 3320
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
93 PRKACA 5566
Affinity Capture-MS Homo sapiens
94 RBM4 5936
Affinity Capture-MS Homo sapiens
95 TTC29  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
96 SERBP1 26135
Affinity Capture-MS Homo sapiens
97 MIPOL1  
Two-hybrid Homo sapiens
98 INCA1  
Two-hybrid Homo sapiens
99 ZNF774  
Two-hybrid Homo sapiens
100 CCND3  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which CDK18 is involved
No pathways found





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