Gene description for PEG3
Gene name paternally expressed 3
Gene symbol PEG3
Other names/aliases PW1
ZKSCAN22
ZNF904
ZSCAN24
Species Homo sapiens
 Database cross references - PEG3
ExoCarta ExoCarta_5178
Vesiclepedia VP_5178
Entrez Gene 5178
HGNC 8826
MIM 601483
UniProt Q9GZU2  
 PEG3 identified in sEVs derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for PEG3
Molecular Function
    RNA polymerase II transcription regulatory region sequence-specific DNA binding GO:0000977 IBA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA
    metal ion binding GO:0046872 IEA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 ISS
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    apoptotic process GO:0006915 IEA
    regulation of gene expression GO:0010468 ISS
    positive regulation of transcription by RNA polymerase II GO:0045944 ISS
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 ISS
    autophagosome GO:0005776 ISS
 Experiment description of studies that identified PEG3 in sEVs
1
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for PEG3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SIAH1  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
2 PEG3 5178
Co-crystal Structure Homo sapiens
Co-crystal Structure Homo sapiens
3 ALB 213
Affinity Capture-MS Homo sapiens
4 BRCA1 672
Far Western Homo sapiens
5 USP7 7874
Two-hybrid Homo sapiens
6 TRAF2 7186
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
7 SIAH2 6478
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which PEG3 is involved
No pathways found





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