Gene description for MAP3K1
Gene name	mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
Gene symbol	MAP3K1
Other names/aliases	MAPKKK1 MEKK MEKK 1 MEKK1 SRXY6
Species	Homo sapiens
Database cross references - MAP3K1
ExoCarta	ExoCarta_4214
Entrez Gene	4214
HGNC	6848
MIM	600982
UniProt	Q13233
MAP3K1 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells	Unpublished / Not applicable

Gene ontology annotations for MAP3K1

Molecular Function     protein kinase binding GO:0019901 IPI     JUN kinase kinase activity GO:0008545 IEA     MAP kinase kinase kinase activity GO:0004709 NAS     protein kinase activity GO:0004672 IDA     zinc ion binding GO:0008270 IEA     protein binding GO:0005515 IPI     ATP binding GO:0005524 IEA Biological Process     regulation of mitotic cell cycle GO:0007346 IBA     wound healing GO:0042060 IEA     regulation of cell migration GO:0030334 IEA     toll-like receptor TLR6:TLR2 signaling pathway GO:0038124 TAS     activation of MAPKK activity GO:0000186 NAS     activation of protein kinase activity GO:0032147 IBA     eyelid development in camera-type eye GO:0061029 IEA     protein phosphorylation GO:0006468 NAS     Fc-epsilon receptor signaling pathway GO:0038095 TAS     MyD88-dependent toll-like receptor signaling pathway GO:0002755 TAS     toll-like receptor 5 signaling pathway GO:0034146 TAS     toll-like receptor signaling pathway GO:0002224 TAS     epithelial cell morphogenesis GO:0003382 IEA     toll-like receptor 4 signaling pathway GO:0034142 TAS     stress-activated MAPK cascade GO:0051403 IBA     transforming growth factor beta receptor signaling pathway GO:0007179 IEA     innate immune response GO:0045087 TAS     toll-like receptor 10 signaling pathway GO:0034166 TAS     toll-like receptor TLR1:TLR2 signaling pathway GO:0038123 TAS     toll-like receptor 9 signaling pathway GO:0034162 TAS     activation of JUN kinase activity GO:0007257 IEA     positive regulation of actin filament polymerization GO:0030838 IEA     cellular response to mechanical stimulus GO:0071260 IEP     apoptotic mitochondrial changes GO:0008637 IEA     regulation of apoptotic process GO:0042981 IBA     toll-like receptor 2 signaling pathway GO:0034134 TAS Subcellular Localization     cytoplasm GO:0005737 IBA     cytosol GO:0005829 TAS