Gene description for PRKAB2
Gene name protein kinase, AMP-activated, beta 2 non-catalytic subunit
Gene symbol PRKAB2
Other names/aliases -
Species Homo sapiens
 Database cross references - PRKAB2
ExoCarta ExoCarta_5565
Entrez Gene 5565
HGNC 9379
MIM 602741
UniProt O43741  
 PRKAB2 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for PRKAB2
Molecular Function
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 IPI
    AMP-activated protein kinase activity GO:0004679 IDA
Biological Process
    small molecule metabolic process GO:0044281 TAS
    insulin receptor signaling pathway GO:0008286 TAS
    transcription initiation from RNA polymerase II promoter GO:0006367 TAS
    cellular lipid metabolic process GO:0044255 TAS
    membrane organization GO:0061024 TAS
    gene expression GO:0010467 TAS
    regulation of fatty acid biosynthetic process GO:0042304 TAS
    organelle organization GO:0006996 TAS
    cell cycle arrest GO:0007050 TAS
    signal transduction GO:0007165 TAS
    regulation of protein kinase activity GO:0045859 IEA
    mitochondrion organization GO:0007005 TAS
    energy reserve metabolic process GO:0006112 TAS
    carnitine shuttle GO:0006853 TAS
    protein phosphorylation GO:0006468 IDA
    fatty acid biosynthetic process GO:0006633 IEA
Subcellular Localization
    nucleoplasm GO:0005654 TAS
    AMP-activated protein kinase complex GO:0031588 IDA
    cytosol GO:0005829 TAS
 Experiment description of studies that identified PRKAB2 in exosomes
1
Experiment ID 224
ISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81
EV Membrane markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for PRKAB2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PRKAG2 51422
Two-hybrid Homo sapiens
2 PRKAG1 5571
Two-hybrid Homo sapiens
3 PRKAB1  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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