Gene description for LPIN3
Gene name lipin 3
Gene symbol LPIN3
Other names/aliases LIPN3L
SMP2
Species Homo sapiens
 Database cross references - LPIN3
ExoCarta ExoCarta_64900
Vesiclepedia VP_64900
Entrez Gene 64900
HGNC 14451
MIM 605520
UniProt Q9BQK8  
 LPIN3 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Thymus 23844026    
 Gene ontology annotations for LPIN3
Molecular Function
    transcription coactivator activity GO:0003713 IBA
    phosphatidate phosphatase activity GO:0008195 IBA
Biological Process
    fatty acid catabolic process GO:0009062 IBA
    triglyceride biosynthetic process GO:0019432 IBA
    cellular response to insulin stimulus GO:0032869 IBA
    positive regulation of transcription by RNA polymerase II GO:0045944 IBA
Subcellular Localization
    nucleus GO:0005634 IBA
    endoplasmic reticulum membrane GO:0005789 TAS
 Experiment description of studies that identified LPIN3 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for LPIN3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DENND4C 55667
Affinity Capture-MS Homo sapiens
2 LRFN1  
Affinity Capture-MS Homo sapiens
3 SMG6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 SH3RF3  
Affinity Capture-MS Homo sapiens
5 HDAC4  
Affinity Capture-MS Homo sapiens
6 GIGYF2 26058
Affinity Capture-MS Homo sapiens
7 MAPKAP1 79109
Affinity Capture-MS Homo sapiens
8 TRAF2 7186
Affinity Capture-MS Homo sapiens
9 DCLK1 9201
Affinity Capture-MS Homo sapiens
10 KSR1  
Affinity Capture-MS Homo sapiens
11 RALGPS2 55103
Affinity Capture-MS Homo sapiens
12 Tmed10 68581
Affinity Capture-MS Mus musculus
13 XPO1 7514
Affinity Capture-MS Homo sapiens
14 RTKN 6242
Affinity Capture-MS Homo sapiens
15 DENND1A 57706
Affinity Capture-MS Homo sapiens
16 PPM1H  
Affinity Capture-MS Homo sapiens
17 YWHAE 7531
Affinity Capture-MS Homo sapiens
18 OSBPL6  
Affinity Capture-MS Homo sapiens
19 INPP5E 56623
Affinity Capture-MS Homo sapiens
20 RASAL2 9462
Affinity Capture-MS Homo sapiens
21 BIRC2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 RPTOR 57521
Affinity Capture-MS Homo sapiens
23 YWHAZ 7534
Affinity Capture-MS Homo sapiens
24 NF1 4763
Affinity Capture-MS Homo sapiens
25 SRGAP2 23380
Affinity Capture-MS Homo sapiens
26 CSNK2A1 1457
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 CAMSAP2  
Affinity Capture-MS Homo sapiens
28 CBY1  
Affinity Capture-MS Homo sapiens
29 CWC25 54883
Affinity Capture-MS Homo sapiens
30 HIST1H2AG 8969
Cross-Linking-MS (XL-MS) Homo sapiens
31 HDAC6 10013
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 EIF4E2  
Affinity Capture-MS Homo sapiens
33 TESK2  
Affinity Capture-MS Homo sapiens
34 LPIN1 23175
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 RPL32 6161
Cross-Linking-MS (XL-MS) Homo sapiens
36 KIF13B 23303
Affinity Capture-MS Homo sapiens
37 CDC25C  
Affinity Capture-MS Homo sapiens
38 BIRC6 57448
Affinity Capture-MS Homo sapiens
39 CGN  
Affinity Capture-MS Homo sapiens
40 LIMA1 51474
Affinity Capture-MS Homo sapiens
41 NADK 65220
Affinity Capture-MS Homo sapiens
42 PTPN13 5783
Affinity Capture-MS Homo sapiens
43 DYRK1A 1859
Affinity Capture-MS Homo sapiens
44 ZBTB21  
Affinity Capture-MS Homo sapiens
45 GIGYF1  
Affinity Capture-MS Homo sapiens
46 CSNK2A2 1459
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 HIST1H1E 3008
Cross-Linking-MS (XL-MS) Homo sapiens
48 ZNF638 27332
Affinity Capture-MS Homo sapiens
49 MAGI1  
Affinity Capture-MS Homo sapiens
50 CAMKK1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 Setd2  
Affinity Capture-MS Mus musculus
52 LPIN2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 YWHAG 7532
Affinity Capture-MS Homo sapiens
54 MAST3  
Affinity Capture-MS Homo sapiens
55 SIPA1L1 26037
Affinity Capture-MS Homo sapiens
56 TANC2  
Affinity Capture-MS Homo sapiens
57 KCTD3  
Affinity Capture-MS Homo sapiens
58 ENAH 55740
Affinity Capture-MS Homo sapiens
59 VASP 7408
Affinity Capture-MS Homo sapiens
60 NFXL1 152518
Affinity Capture-MS Homo sapiens
61 SH3PXD2A 9644
Affinity Capture-MS Homo sapiens
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