Gene description for TAB3
Gene name TGF-beta activated kinase 1/MAP3K7 binding protein 3
Gene symbol TAB3
Other names/aliases MAP3K7IP3
NAP1
Species Homo sapiens
 Database cross references - TAB3
ExoCarta ExoCarta_257397
Vesiclepedia VP_257397
Entrez Gene 257397
HGNC 30681
MIM 300480
UniProt Q8N5C8  
 TAB3 identified in sEVs derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for TAB3
Molecular Function
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 IDA
    ubiquitin binding GO:0043130 IEA
    molecular adaptor activity GO:0060090 IDA
    K63-linked polyubiquitin modification-dependent protein binding GO:0070530 IDA
Biological Process
    negative regulation of autophagy GO:0010507 TAS
    non-canonical NF-kappaB signal transduction GO:0038061 IDA
    defense response to bacterium GO:0042742 IDA
    positive regulation of canonical NF-kappaB signal transduction GO:0043123 IBA
    positive regulation of canonical NF-kappaB signal transduction GO:0043123 IDA
    positive regulation of canonical NF-kappaB signal transduction GO:0043123 IMP
Subcellular Localization
    endoplasmic reticulum GO:0005783 IDA
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 TAS
    endosome membrane GO:0010008 TAS
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified TAB3 in sEVs
1
Experiment ID 237
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for TAB3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 YWHAH 7533
Affinity Capture-MS Homo sapiens
2 UBE2H 7328
Affinity Capture-MS Homo sapiens
3 TRIM5 85363
Affinity Capture-Western Homo sapiens
4 RNF43  
Proximity Label-MS Homo sapiens
5 TRIM38 10475
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
6 SNX27 81609
Affinity Capture-MS Homo sapiens
7 WDR34 89891
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
8 TRAF2 7186
Affinity Capture-Western Homo sapiens
9 ETV6  
Proximity Label-MS Homo sapiens
10 SMAD7  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
11 ATG5 9474
Co-localization Homo sapiens
12 PIN1 5300
Two-hybrid Homo sapiens
13 YWHAE 7531
Affinity Capture-MS Homo sapiens
14 IKBKG 8517
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
15 TRAF6 7189
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
16 RNF4 6047
Affinity Capture-Western Homo sapiens
17 CARD11  
Affinity Capture-Western Homo sapiens
18 TAB1 10454
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
19 UBC 7316
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
20 Trim30a  
Affinity Capture-Western Mus musculus
21 TAB3 257397
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
22 MAP3K7  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
23 ESR1  
Affinity Capture-MS Homo sapiens
24 ATG13 9776
Affinity Capture-Western Homo sapiens
25 WWP2 11060
Affinity Capture-MS Homo sapiens
26 EMILIN1 11117
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 BECN1 8678
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
28 PBXIP1 57326
Affinity Capture-Western Homo sapiens
29 YAP1 10413
Affinity Capture-MS Homo sapiens
30 CEP57L1  
Two-hybrid Homo sapiens
31 IFI16 3428
Affinity Capture-MS Homo sapiens
32 TAB2  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
33 TRIM27  
Affinity Capture-Western Homo sapiens
34 NOMO3 408050
Affinity Capture-MS Homo sapiens
35 BICD2 23299
Proximity Label-MS Homo sapiens
36 BICD1 636
Proximity Label-MS Homo sapiens
37 STAT3 6774
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
38 CALCOCO2  
Affinity Capture-Western Homo sapiens
39 IKBKB 3551
Affinity Capture-Western Homo sapiens
40 PRMT1 3276
Affinity Capture-MS Homo sapiens
41 RBCK1  
Affinity Capture-Western Homo sapiens
42 MAP3K7CL  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
43 AKAP1 8165
Proximity Label-MS Homo sapiens
44 CYLD  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which TAB3 is involved
PathwayEvidenceSource
activated TAK1 mediates p38 MAPK activation TAS Reactome
Alpha-protein kinase 1 signaling pathway TAS Reactome
C-type lectin receptors (CLRs) TAS Reactome
CLEC7A (Dectin-1) signaling TAS Reactome
Cytokine Signaling in Immune system TAS Reactome
Death Receptor Signaling TAS Reactome
Disease TAS Reactome
Fc epsilon receptor (FCERI) signaling TAS Reactome
FCERI mediated NF-kB activation TAS Reactome
Immune System TAS Reactome
Infectious disease TAS Reactome
Innate Immune System TAS Reactome
Interleukin-1 family signaling TAS Reactome
Interleukin-1 signaling TAS Reactome
Interleukin-17 signaling TAS Reactome
IRAK2 mediated activation of TAK1 complex TAS Reactome
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation TAS Reactome
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 TAS Reactome
MAP kinase activation TAS Reactome
MyD88 cascade initiated on plasma membrane TAS Reactome
MyD88 dependent cascade initiated on endosome TAS Reactome
MyD88-independent TLR4 cascade TAS Reactome
MyD88:MAL(TIRAP) cascade initiated on plasma membrane TAS Reactome
NOD1/2 Signaling Pathway TAS Reactome
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways TAS Reactome
SARS-CoV Infections TAS Reactome
SARS-CoV-2 activates/modulates innate and adaptive immune responses TAS Reactome
SARS-CoV-2 Infection TAS Reactome
SARS-CoV-2-host interactions TAS Reactome
Signal Transduction TAS Reactome
Signaling by Interleukins TAS Reactome
TAK1-dependent IKK and NF-kappa-B activation TAS Reactome
TICAM1,TRAF6-dependent induction of TAK1 complex TAS Reactome
TNF signaling TAS Reactome
TNFR1-induced NF-kappa-B signaling pathway TAS Reactome
Toll Like Receptor 10 (TLR10) Cascade TAS Reactome
Toll Like Receptor 2 (TLR2) Cascade TAS Reactome
Toll Like Receptor 3 (TLR3) Cascade TAS Reactome
Toll Like Receptor 4 (TLR4) Cascade TAS Reactome
Toll Like Receptor 5 (TLR5) Cascade TAS Reactome
Toll Like Receptor 7/8 (TLR7/8) Cascade TAS Reactome
Toll Like Receptor 9 (TLR9) Cascade TAS Reactome
Toll Like Receptor TLR1:TLR2 Cascade TAS Reactome
Toll Like Receptor TLR6:TLR2 Cascade TAS Reactome
Toll-like Receptor Cascades TAS Reactome
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation TAS Reactome
TRAF6-mediated induction of TAK1 complex within TLR4 complex TAS Reactome
TRIF (TICAM1)-mediated TLR4 signaling TAS Reactome
Viral Infection Pathways TAS Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here